Fos regulates age-dependent neuroinflammation in a VAPP58S model of amyotrophic lateral sclerosis.
Overview
Abstract
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive loss of motor function. Here, we developed a Drosophila model of ALS8 (VAPBP58S) using CRISPR/
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
The paper links to its data, not to its authors' code: see the Data section.
Tracing map
A tracing map links a paper to the code its authors published: this paper has none, so it has no map.
Data
Datasets cited
- geo:GSE333178, at NCBI GEO; found in the end of the paper
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 7 authors, 5 keywords, 14 MeSH terms, 4 funders, 112 references, 1 RRID.
Cite
This paper
Kulkarni, N. P., Thulasidharan, A., Soory, A., Goel, P., Sarkar, S., Kelkar, V., & Ratnaparkhi, G. S. (2026). Fos regulates age-dependent neuroinflammation in a VAPP58S model of amyotrophic lateral sclerosis. Disease models & mechanisms, 19(7), dmm052810. https://
BibTeX
@article{kulkarni2026fos
author = {Kulkarni, Namrata Pramod and Thulasidharan, Aparna and Soory, Amarendranath and Goel, Pulkit and Sarkar, Sanhita and Kelkar, Vidyadheesh and Ratnaparkhi, Girish S.},
title = {{Fos regulates age-dependent neuroinflammation in a VAPP58S model of amyotrophic lateral sclerosis}},
journal = {Disease models \& mechanisms},
year = {2026},
month = jul,
volume = {19},
number = {7},
pages = {dmm052810},
publisher = {Company of Biologists},
issn = {1754-8403},
doi = {10.1242/
url = {https://
pmid = {42237814},
pmcid = {PMC13446562}
}
RIS
TY - JOUR
AU - Kulkarni, Namrata Pramod
AU - Thulasidharan, Aparna
AU - Soory, Amarendranath
AU - Goel, Pulkit
AU - Sarkar, Sanhita
AU - Kelkar, Vidyadheesh
AU - Ratnaparkhi, Girish S.
TI - Fos regulates age-dependent neuroinflammation in a VAPP58S model of amyotrophic lateral sclerosis
T2 - Disease models & mechanisms
J2 - Dis Model Mech
PY - 2026
DA - 2026/
VL - 19
IS - 7
SP - dmm052810
SN - 1754-8403
PB - Company of Biologists
DO - 10.1242/
UR - https://
LA - en
ER -
CSL-JSON
{
"id": "10.1242/
"type": "article-journal",
"title": "Fos regulates age-dependent neuroinflammation in a VAPP58S model of amyotrophic lateral sclerosis",
"container-title": "Disease models & mechanisms",
"author": [
{
"family": "Kulkarni",
"given": "Namrata Pramod"
},
{
"family": "Thulasidharan",
"given": "Aparna"
},
{
"family": "Soory",
"given": "Amarendranath"
},
{
"family": "Goel",
"given": "Pulkit"
},
{
"family": "Sarkar",
"given": "Sanhita"
},
{
"family": "Kelkar",
"given": "Vidyadheesh"
},
{
"family": "Ratnaparkhi",
"given": "Girish S."
}
],
"container-title-short":
"volume": "19",
"issue": "7",
"page": "dmm052810",
"DOI": "10.1242/
"PMID": "42237814",
"PMCID": "PMC13446562",
"ISSN": "1754-8403",
"publisher": "Company of Biologists",
"URL": "https://
"language": "en",
"issued": {
"date-parts": [
[
2026,
7,
24
]
]
}
}
Similar papers
The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.
- [1] doi:10.1186/s40478-026-02391-y
- Neuro-glial lipid imbalance in a Drosophila model of amyotrophic lateral sclerosis 8.Journal: Acta neuropathologica communicationsIn common: drosophila, other condition, cellular / molecular, 19 references, author Girish Ratnaparkhi
- [2] doi:10.1038/s41593-026-02300-5 [code]
- Integrated single-cell and spatial transcriptomic profiling in ALS uncovers peripheral-to-central immune infiltration and reprogramming.Journal: Nature neuroscienceIn common: other condition, cellular / molecular, 4 references
- [3] doi:10.1186/s12974-026-03837-9
- PTP1B in astrocytes drives pathogen-induced neurodegeneration.Journal: Journal of neuroinflammationIn common: other condition, cellular / molecular, 3 references
- [4] doi:10.1073/pnas.2605750123
- Light- and temperature-sensitive seizures are regulated by spatially distinct cortex glial populations in the central nervous system.Journal: Proceedings of the National Academy of Sciences of the United States of AmericaIn common: drosophila, cellular / molecular, 2 references
- [5] doi:10.1172/jci.insight.198842
- Fatty acid amide hydrolase inhibition for treatment of amyotrophic lateral sclerosis.Journal: JCI insightIn common: other condition, 2 references
- [6] doi:10.1007/s00415-026-14134-z
- What do ALS motor phenotypes measure? A population-based decomposition of their prognostic dimensions.Journal: Journal of neurologyIn common: other condition, 2 references
- [7] doi:10.1093/brain/awaf360
- MYC-driven gliosis impairs neuron-glia communication in amyotrophic lateral sclerosis.Journal: Brain : a journal of neurologyIn common: other condition, cellular / molecular, 2 references
- [8] doi:10.1016/j.cell.2026.05.047 [code]
- An emergent disease-associated motor neuron state precedes cell death in ALS.Journal: CellIn common: other condition, cellular / molecular, 2 references
- [9] doi:10.1038/s41593-026-02354-5 [code]
- Focal astrocyte loss reveals nuclear translocation during lesion repopulation.Journal: Nature neuroscienceIn common: cellular / molecular, 3 references
- [10] doi:10.1038/s44318-026-00817-w
- The C9orf72/
SMCR8 complex maintains microglial homeostasis via RAB8A-ESCRT-mediated lysosomal repair. Journal: The EMBO journalIn common: cellular / molecular, 2 references
Contribute
The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.
Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.
Claim this paper
Correct its record
Say what each link of this record is, remove the ones that are not the paper's, add the ones that are missing. The correction becomes a new version of the record, in its Versions section.
Request its removal
To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).
Discussion, reproductions, activity
Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.
Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.
Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.