Diagnostic performance of peripheral nerve palpation compared with ultrasonography in leprosy neuropathy: A prospective real-world clinical evaluation.
Overview
- Programa de Pós-Graduação em Ciências Aplicadas à Dermatologia, Universidade do Estado do Amazonas, Manaus, Brazil
- Fundação Hospitalar Alfredo da Matta, Manaus, Brazil
- Instituto Nacional de Infectologia (IPEC) Fundação Oswaldo Cruz, Rio de Janeiro, Brazil
- Lab. de Microbiologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil
- Departamento de Dermatologia e Radioterapia da FMB-UNESP, Botucatu, Brazil
Abstract
Background: Leprosy frequently causes peripheral neuropathy, and nerve palpation remains a cornerstone of diagnosis in many endemic settings despite its subjectivity and limited reproducibility. High-resolution ultrasonography has emerged as a sensitive, low-cost imaging tool to detect peripheral nerve involvement. We aimed to compare the diagnostic performance and interobserver agreement of peripheral nerve palpation versus ultrasonography for detecting leprosy neuropathy, with particular focus on pure neural forms.
Methodology/
Conclusions/
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
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Data
Datasets cited
- doi:10.17632/
9mpwgnw523.1 , at the source; found in “Data Availability”
Data Availability
Raw data of this study are available at https://
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Versions
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Version 1, 29 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 10 authors, 15 MeSH terms, 1 funder, 36 references.
Cite
This paper
da Silva Mendes, J., Montenegro da Silva, T., Tavares Cruz, P., dos Santos Cordeiro, A. G., da Mata Serique, R., Alves, M. R., Alves Lara, F., Talhari, C., Amante Miot, H., & Talhari, S. (2026). Diagnostic performance of peripheral nerve palpation compared with ultrasonography in leprosy neuropathy: A prospective real-world clinical evaluation. PLoS neglected tropical diseases, 20(4), e0014234. https://
BibTeX
@article{dasilvamendes20
author = {da Silva Mendes, Jaqueline and Montenegro da Silva, Thiago and Tavares Cruz, Patricia and dos Santos Cordeiro, Amanda Gabrielle and da Mata Serique, Raquel and Alves, Marcelo Ribeiro and Alves Lara, Flavio and Talhari, Carolina and Amante Miot, Hélio and Talhari, Sinésio},
title = {{Diagnostic performance of peripheral nerve palpation compared with ultrasonography in leprosy neuropathy: A prospective real-world clinical evaluation}},
journal = {PLoS neglected tropical diseases},
year = {2026},
month = apr,
volume = {20},
number = {4},
pages = {e0014234},
publisher = {PLOS},
issn = {1935-2727},
doi = {10.1371/
url = {https://
pmid = {42013148},
pmcid = {PMC13143118}
}
RIS
TY - JOUR
AU - da Silva Mendes, Jaqueline
AU - Montenegro da Silva, Thiago
AU - Tavares Cruz, Patricia
AU - dos Santos Cordeiro, Amanda Gabrielle
AU - da Mata Serique, Raquel
AU - Alves, Marcelo Ribeiro
AU - Alves Lara, Flavio
AU - Talhari, Carolina
AU - Amante Miot, Hélio
AU - Talhari, Sinésio
TI - Diagnostic performance of peripheral nerve palpation compared with ultrasonography in leprosy neuropathy: A prospective real-world clinical evaluation
T2 - PLoS neglected tropical diseases
J2 - PLoS Negl Trop Dis
PY - 2026
DA - 2026/
VL - 20
IS - 4
SP - e0014234
SN - 1935-2727
PB - PLOS
DO - 10.1371/
UR - https://
LA - en
ER -
CSL-JSON
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