STAT4-dependent regulation of neuroinflammation in atherosclerosis.
Overview
- Department of Biomedical and Translational Science, Eastern Virginia Medical School, Macon & Joan Brock Virginia Health Sciences at Old Dominion University, Norfolk, Virginia, USA
- Center for Integrative Neuroscience and Inflammatory Diseases, Eastern Virginia Medical School, Macon & Joan Brock Virginia Health Sciences at Old Dominion University, Norfolk, Virginia, USA
- Division of Microbiology, Department of Microbiology, Tulane National Primate Research Center, Covington, Louisiana, USA
- Department of Microbiology & Immunology, Tulane University School of Medicine, New Orleans, Louisiana, USA
Abstract
Atherosclerosis is linked to an increased risk of cognitive decline, with chronic inflammation being a common feature of both pathologies. IL‐12 activates STAT4 to regulate myeloid cell functions, and blockade of this pathway alleviates cognitive impairment in Alzheimer's models. However, the mechanisms connecting vascular pathology to neuroinflammation remain unclear. Here, we examine whether STAT4 functions as a common mediator of neuroinflammation in atherosclerosis. We demonstrate that LysMCre‐specific STAT4 deficiency ameliorates deficits in long‐term memory in low‐density lipoprotein‐deficient (Ldlr −/
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
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Data
Datasets cited
- geo:GSE240045 — at NCBI GEO; found in the text, “Over‐representation analysis”
Data availability statement
All data associated with this study are present in the paper. Data will be made available upon reasonable request.
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 1, 28 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 7 authors, 5 keywords, 12 MeSH terms, 4 funders, 62 references, 18 RRIDs.
Cite
This paper
Stahr, N., Moriarty, A. K., Ma, S. D., Keeter, W. C., Kim, W., Sanford, L. D., & Galkina, E. V. (2026). STAT4-dependent regulation of neuroinflammation in atherosclerosis. Physiological reports, 14(7), e70856. https://
BibTeX
@article{stahr2026stat4,
author = {Stahr, Natalie and Moriarty, Alina K and Ma, Shelby D and Keeter, W Coles and Kim, Woong‐Ki and Sanford, Larry D and Galkina, Elena V},
title = {{STAT4-dependent regulation of neuroinflammation in atherosclerosis}},
journal = {Physiological reports},
year = {2026},
month = apr,
volume = {14},
number = {7},
pages = {e70856},
publisher = {Wiley},
issn = {2051-817X},
doi = {10.14814/
url = {https://
pmid = {41943474},
pmcid = {PMC13053938}
}
RIS
TY - JOUR
AU - Stahr, Natalie
AU - Moriarty, Alina K
AU - Ma, Shelby D
AU - Keeter, W Coles
AU - Kim, Woong‐Ki
AU - Sanford, Larry D
AU - Galkina, Elena V
TI - STAT4-dependent regulation of neuroinflammation in atherosclerosis
T2 - Physiological reports
J2 - Physiol Rep
PY - 2026
DA - 2026/
VL - 14
IS - 7
SP - e70856
SN - 2051-817X
PB - Wiley
DO - 10.14814/
UR - https://
LA - en
ER -
CSL-JSON
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