OSCR

Attenuation of typical sex differences in the time-resolved functional connectivity of the fusiform gyrus in autism

Code ↔ Paper

The paper beside its authors' code: matches between them have not been computed for this paper yet.

Paper

Loaded from Europe PMC by your browser, not stored by OSCR: doi.org · Europe PMC

The paper is loaded when this pane is shown.

The authors' code

MATLAB · 42 lines · 1.1 KB · Apache-2.0

  1. function [dis_final] = mCAP_CAP_CompareSeeds(seed1,seed2)
  2. seed1=double(seed1);
  3. seed2=double(seed2);
  4. % Cosine distance between seeds
  5. DIS = pdist2(seed1',seed2','cosine');
  7. n_voxels = sum(sum(seed1));
  9. % Matching pairs
  10. IDX = munkres(DIS);
  12. idxk = 1;
  14. for k=1:size(DIS,1)
  15. if sum(IDX(k,:)) == 1
  16. dis_final(idxk) = DIS(k,IDX(k,:));
  17. idxk = idxk + 1;
  18. else
  20. end
  21. end
  23. dis_final = dis_final;%/n_voxels;
  26. %% check all the points
  27. end
  30. % Copyright 2023 Farnaz Delavari
  31. %
  32. % Licensed under the Apache License, Version 2.0 (the "License");
  33. % you may not use this file except in compliance with the License.
  34. % You may obtain a copy of the License at
  35. %
  36. % http://www.apache.org/licenses/LICENSE-2.0
  37. %
  38. % Unless required by applicable law or agreed to in writing, software
  39. % distributed under the License is distributed on an "AS IS" BASIS,
  40. % WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
  41. % See the License for the specific language governing permissions and
  42. % limitations under the License.

mCAP_CAP_CompareSeeds.m at commit 643a24b, under Apache-2.0 · at the source

Overview

Authors: Dorothea Floris1, Luigi Saccaro2, Farnaz Delavari3, Dawid Strzelczyk, Bruno Hebling Vieira, Camille Elleaume, Charlotte Pretzsch4, Christine Ecker5, Tobias Banaschewski6, Rosemary Holt, Simon Baron-Cohen7, Thomas Bourgeron8, Tony Charman, Eva Loth, Declan Murphy9, Jan Buitelaar10, Christian Beckmann11, Dimitri Van De Ville12, Nicolas Langer1
ORCID iDs: Luigi Saccaro, Farnaz Delavari, Charlotte Pretzsch, Tobias Banaschewski, Simon Baron-Cohen, Tony Charman, Eva Loth, Declan Murphy, Jan Buitelaar, Dimitri Van De Ville
  1. University of Zurich
  2. University of Geneva
  3. École Polytechnique Fédérale de Lausanne
  4. Institute of Psychiatry, Psychology, and Neuroscience, King’s College London
  5. Goethe University Frankfurt
  6. Central Institute of Mental Health, Mannheim
  7. University of Cambridge
  8. Institut Pasteur, Human Genetics and Cognitive Functions Unit
  9. King’s College London
  10. Radboud University Medical Center
  11. Donders Institute - Radboud University
  12. Ecole polytechnique fédérale de Lausanne
Institutions: University of Zurich (Switzerland); University of Geneva (Switzerland); École Polytechnique Fédérale de Lausanne (Switzerland); King's College London (United Kingdom); Goethe University Frankfurt (Germany); Central Institute of Mental Health (Germany); University of Cambridge (United Kingdom); Institut Pasteur (France); Radboud University Medical Center (Netherlands); Donders Institute for Brain, Cognition and Behaviour (Netherlands)
Journal: Research Square (preprint)
Dates: published online 22 July 2026
Type: Preprint
License: CC BY
Identifiers: DOI 10.21203/rs.3.rs-10317780/v1 · OpenAlex W7170030992
Open access: green, a free copy (OpenAlex)
Status: code verified
Categories: fMRI (modality), autism (population)
Methods: Statistics, Smoothing, state filtering, decompositions, Machine learning, fMRI & imaging
Topic: Functional Brain Connectivity Studies (Cognitive Neuroscience, Neuroscience), according to OpenAlex
Funding: Wellcome Trust (098369/Z/12/Z, 214322); National Institute for Health Research (NIHR) (NIHR203312)
Citations: not cited yet (Europe PMC); 100 references in the paper

Abstract

Autism is characterized by social-communicative difficulties, with sex differences in symptom presentation. Social functioning is inherently dynamic, however, many neuroimaging studies rely on static, time-averaged approaches that obscure time-varying network interactions, potentially limiting our ability to capture the dynamic processes underlying social cognition. The fusiform gyrus (FFG), central to face and social perception, shows differences in functional connectivity in autism, yet is rarely examined dynamically or as a spatially heterogeneous structure. Here, we investigate the dynamic functional connectivity of FFG subregions in terms of their large-scale network configurations as a function of diagnosis and sex. We applied micro co-activation patterns analysis (µCAPs) to resting-state fMRI data from 286 autistic individuals (208:78 males:females) and 228 non-autistic individuals (146:82 males:females), aged 6–30 years, from the EU-AIMS LEAP dataset. µCAPs were identified using k-means clustering with FFG as the seed, and connectopic mapping positioned each µCAP along the principal connectivity gradient. We quantified µCAPs occurrence and further examined dwell time, transition probabilities, and spatial extent, along with associations with social functioning. Six µCAPs mapped onto distinct FFG subregions along a posterior-anterior axis. A significant sex-by-diagnosis interaction emerged for a default mode network (DMN)-related µCAP. Non-autistic females exhibited significantly more frequent occurrences, longer dwell times and distinct transition dynamics compared to males, while no sex difference was observed in autism. The spatial extent of this µCAP showed a reversal of typical sex effects. Autism is associated with an attenuation and reversal of typical sex differences in the functional configuration and spatial extent of FFG-DMN coupling, indicating that neural signatures of social-cognitive functions are sex-specific and dynamic. These findings suggest that sex is a neurobiologically meaningful dimension of heterogeneity in autism, expressed in dynamic network organization.

Reproduced under the paper's license (CC BY), from the paper cited above.

Repository

Its files are read in the Code ↔ Paper reader above.

MIPLabCH/mCAP

License: Apache-2.0
State: the link answers, verified on 27 September 2026
Evidence: files inventoried
Commit: 643a24b4cabcb0b410126f4d11fcea71202086ca, 23 November 2024
Languages: MATLAB (10)
Size: 13 files, 10 scripts
Software Heritage: not archived
Found in: the text, “Micro co-activation pattern analysis”
Holds: README, license file
Not found: CITATION.cff, environment file, tests, continuous integration, documentation
Tools: Statistics and Machine Learning Toolbox (6 files), Parallel Computing Toolbox (3 files)
Availability: 1 check, the latest on 27 September 2026: the link answers
  • 27 September 2026: the link answers
12 files
At the source: github.com/MIPLabCH/mCAP

Tracing map

Proposed by the machine: these links were found in the paper and verified at the source, without human review. The map will receive a Zenodo DOI once one of the paper's authors has validated it with their ORCID.

What the map holds:

  • 1 repository of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
  • 10 scripts, each with its path and the digest of its content;
  • no match between paragraphs and code yet;
  • neither the text of the paper nor the code itself.

Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

No dataset and no data link were found in the paper.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 27 September 2026: the first record

Recorded: type, journal, dates, 19 authors, 2 funders, 99 references.

Cite

This paper

Floris, D., Saccaro, L., Delavari, F., Strzelczyk, D., Vieira, B. H., Elleaume, C., Pretzsch, C., Ecker, C., Banaschewski, T., Holt, R., Baron-Cohen, S., Bourgeron, T., Charman, T., Loth, E., Murphy, D., Buitelaar, J., Beckmann, C., Van De Ville, D., & Langer, N. (2026). Attenuation of typical sex differences in the time-resolved functional connectivity of the fusiform gyrus in autism. Research Square (preprint). https://doi.org/10.21203/rs.3.rs-10317780/v1

BibTeX

@article{floris2026attenuation,
author = {Floris, Dorothea and Saccaro, Luigi and Delavari, Farnaz and Strzelczyk, Dawid and Vieira, Bruno Hebling and Elleaume, Camille and Pretzsch, Charlotte and Ecker, Christine and Banaschewski, Tobias and Holt, Rosemary and Baron-Cohen, Simon and Bourgeron, Thomas and Charman, Tony and Loth, Eva and Murphy, Declan and Buitelaar, Jan and Beckmann, Christian and Van De Ville, Dimitri and Langer, Nicolas},
title = {{Attenuation of typical sex differences in the time-resolved functional connectivity of the fusiform gyrus in autism}},
journal = {Research Square (preprint)},
year = {2026},
month = jul,
publisher = {Research Square},
issn = {2693-5015},
doi = {10.21203/rs.3.rs-10317780/v1},
url = {https://doi.org/10.21203/rs.3.rs-10317780/v1}
}

RIS

TY - JOUR
AU - Floris, Dorothea
AU - Saccaro, Luigi
AU - Delavari, Farnaz
AU - Strzelczyk, Dawid
AU - Vieira, Bruno Hebling
AU - Elleaume, Camille
AU - Pretzsch, Charlotte
AU - Ecker, Christine
AU - Banaschewski, Tobias
AU - Holt, Rosemary
AU - Baron-Cohen, Simon
AU - Bourgeron, Thomas
AU - Charman, Tony
AU - Loth, Eva
AU - Murphy, Declan
AU - Buitelaar, Jan
AU - Beckmann, Christian
AU - Van De Ville, Dimitri
AU - Langer, Nicolas
TI - Attenuation of typical sex differences in the time-resolved functional connectivity of the fusiform gyrus in autism
T2 - Research Square (preprint)
J2 - Res Sq
PY - 2026
DA - 2026/07/22
SN - 2693-5015
PB - Research Square
DO - 10.21203/rs.3.rs-10317780/v1
UR - https://doi.org/10.21203/rs.3.rs-10317780/v1
ER -

CSL-JSON

{
"id": "10.21203/rs.3.rs-10317780/v1",
"type": "article",
"title": "Attenuation of typical sex differences in the time-resolved functional connectivity of the fusiform gyrus in autism",
"container-title": "Research Square (preprint)",
"author": [
{
"family": "Floris",
"given": "Dorothea"
},
{
"family": "Saccaro",
"given": "Luigi"
},
{
"family": "Delavari",
"given": "Farnaz"
},
{
"family": "Strzelczyk",
"given": "Dawid"
},
{
"family": "Vieira",
"given": "Bruno Hebling"
},
{
"family": "Elleaume",
"given": "Camille"
},
{
"family": "Pretzsch",
"given": "Charlotte"
},
{
"family": "Ecker",
"given": "Christine"
},
{
"family": "Banaschewski",
"given": "Tobias"
},
{
"family": "Holt",
"given": "Rosemary"
},
{
"family": "Baron-Cohen",
"given": "Simon"
},
{
"family": "Bourgeron",
"given": "Thomas"
},
{
"family": "Charman",
"given": "Tony"
},
{
"family": "Loth",
"given": "Eva"
},
{
"family": "Murphy",
"given": "Declan"
},
{
"family": "Buitelaar",
"given": "Jan"
},
{
"family": "Beckmann",
"given": "Christian"
},
{
"family": "Van De Ville",
"given": "Dimitri"
},
{
"family": "Langer",
"given": "Nicolas"
}
],
"container-title-short": "Res Sq",
"DOI": "10.21203/rs.3.rs-10317780/v1",
"ISSN": "2693-5015",
"publisher": "Research Square",
"URL": "https://doi.org/10.21203/rs.3.rs-10317780/v1",
"issued": {
"date-parts": [
[
2026,
7,
22
]
]
}
}

The tracing map gets a citation of its own once an author has validated it and it has a DOI.

Similar papers

The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.

[1] doi:10.64898/2026.06.02.26354318 [code]
Attenuation of typical sex differences in the time-resolved functional connectivity of the fusiform gyrus in autism
Journal: medRxiv (preprint)
In common: Parallel Computing Toolbox, Statistics and Machine Learning Toolbox, autism, fMRI, 68 references, 3 authors
[2] doi:10.1038/s44220-026-00656-y [code]
Multiscale heterogeneity of atypical functional connectivity in autism.
Journal: Nature. Mental health
In common: Statistics and Machine Learning Toolbox, autism, fMRI, 3 references, 5 authors
[3] doi:10.1038/s41598-026-42120-y [code]
Qualitative EEG abnormalities in ASD reflect inhibition-dominated brain dynamics.
Journal: Scientific reports
In common: autism, 2 references, 2 authors
[4] doi:10.1038/s41467-026-71270-w [code]
Spatiotemporal dynamics of the human cortical functional hierarchy across the lifespan.
Journal: Nature communications
In common: Parallel Computing Toolbox, Statistics and Machine Learning Toolbox, fMRI, 3 references
[5] doi:10.1016/j.bpsgos.2026.100787 [code]
Dynamic Functional Synchronization Profiles in Autism Differ by Spatial Scale and Along Hierarchical Cortical Gradients.
Journal: Biological psychiatry global open science
In common: Statistics and Machine Learning Toolbox, autism, fMRI, 3 references
[6] doi:10.1038/s41467-026-76011-7 [code]
Human cortex organizes dynamic co-fluctuations along the sensorimotor-association axis.
Journal: Nature communications
In common: Statistics and Machine Learning Toolbox, 4 references
[7] doi:10.1162/imag.a.1254 [code]
The individuality of single-frame functional brain connectivity.
Journal: Imaging neuroscience (Cambridge, Mass.)
In common: Parallel Computing Toolbox, Statistics and Machine Learning Toolbox, fMRI, 2 references
[8] doi:10.1093/psyrad/kkag013 [code]
Convergent and divergent spatial topographies of individualized brain functional networks and their developmental origins.
Journal: Psychoradiology
In common: Parallel Computing Toolbox, Statistics and Machine Learning Toolbox, fMRI, 2 references
[9] doi:10.1038/s41467-026-73668-y [code]
Convergent and divergent brain-cognition development in early adolescence.
Journal: Nature communications
In common: Statistics and Machine Learning Toolbox, fMRI, 3 references
[10] doi:10.21203/rs.3.rs-10155262/v1
Functional Gradients of the Neuraxis: Reorganization from Cortex to Spinal Cord
Journal: Research Square (preprint)
In common: fMRI, author Dimitri Van De Ville

Contribute

The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.

Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.

Request its removal

To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).

Discussion, reproductions, activity

Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.

Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.

Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.