Brain Functional Network Alterations in Adolescents With Major Depressive Disorder and Suicidal Attempt: A Resting-State fMRI Study.
Overview
- Department of Radiology, Deyang People's Hospital, 618000 Deyang, Sichuan, China
- Department of Psychosomatics, Deyang People's Hospital, 618000 Deyang, Sichuan, China
- Department of Radiology, First Hospital of Shanxi Medical University, 030001 Taiyuan, Shanxi, China
Abstract
Background: The neurobiological mechanism underlying suicidal attempts in depressive adolescents remains unknown. This study investigated brain functional network changes in adolescent depression with suicidal attempt.
Methods: First episode, treatment naïve adolescent patients with depression and suicidal attempts, and healthy adolescents matched for age and sex were enrolled. Resting-state functional magnetic resonance images were obtained and whole-brain functional matrices were constructed to analyze functional connectivity differences between the two groups. The graph theory method was used to analyze topological alterations in brain regions with altered functional connectivity. Correlations were analyzed between functional parameters and clinical characteristics.
Results: A total of 47 patients and 33 healthy adolescents were included. Depressed adolescents with suicidal attempts showed lower functional connectivities than did healthy controls in critical brain regions, mainly located in the sensorimotor network, default mode network, cognitive control network, visual network and cerebellum. Graph theory analysis revealed a decreased degree centrality in the right precentral gyrus of patients. Correlation analyses identified a negative association between depressive symptom severity and functional connectivity in the left supplementary motor cortex-inferior parietal lobule in the patient group.
Conclusions: This study revealed functional abnormalities in depressed adolescents with suicidal attempts in critical brain networks that were responsible for emotional regulation, cognitive process and behavioral controls, and suggested critical neurobiological evidence of suicidality in depression.
Reproduced under the paper's license (CC BY), from the paper cited above.
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All the code and data supporting the results of this study can be obtained from the corresponding authors upon reasonable request.
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Version 1, 29 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 6 authors, 5 keywords, 1 funder, 45 references.
Cite
This paper
Peng, W., Yang, Y., Liao, Z., Liu, G., Liu, P., & Zhang, F. (2026). Brain Functional Network Alterations in Adolescents With Major Depressive Disorder and Suicidal Attempt: A Resting-State fMRI Study. Alpha psychiatry, 27(2), 48336. https://
BibTeX
@article{peng2026brain,
author = {Peng, Wei and Yang, Yujie and Liao, Zhenhong and Liu, Gaoyuan and Liu, Ping and Zhang, Feifei},
title = {{Brain Functional Network Alterations in Adolescents With Major Depressive Disorder and Suicidal Attempt: A Resting-State fMRI Study}},
journal = {Alpha psychiatry},
year = {2026},
month = apr,
volume = {27},
number = {2},
pages = {48336},
publisher = {IMR Press},
issn = {2757-8038},
doi = {10.31083/
url = {https://
pmid = {42110892},
pmcid = {PMC13156051}
}
RIS
TY - JOUR
AU - Peng, Wei
AU - Yang, Yujie
AU - Liao, Zhenhong
AU - Liu, Gaoyuan
AU - Liu, Ping
AU - Zhang, Feifei
TI - Brain Functional Network Alterations in Adolescents With Major Depressive Disorder and Suicidal Attempt: A Resting-State fMRI Study
T2 - Alpha psychiatry
J2 - Alpha Psychiatry
PY - 2026
DA - 2026/
VL - 27
IS - 2
SP - 48336
SN - 2757-8038
PB - IMR Press
DO - 10.31083/
UR - https://
LA - en
ER -
CSL-JSON
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