OSCR

Imatinib-Induced Changes in Anxiety-Like Behaviors are Associated With Prefrontal Cortical Metabolic Remodeling in Mice.

Overview

Authors: Jieyu Ji1, You Wang1, Shanglan Qu1,2, Xin Peng1, Ruixue Ma1, Hanwei Li1, Jinlong Chang1, Lijuan Li1, Yanjiao Li1, Zhiting Gong1
ORCID iDs: Zhiting Gong
  1. School of Medicine, Dali University, 671003 Dali, Yunnan, China
  2. School of Pharmacy, Faculty of Health and Medical Sciences, Taylor’s University, 47500 Subang Jaya, Selangor, Malaysia
Institutions: Dali University (China); Taylor's University (Malaysia)
Journal: Alpha psychiatry, volume 27, issue 4, article 51694
Dates: received 10 March 2026; accepted 11 May 2026; published online 17 August 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.31083/ap51694 · PMID 42694897 · PMCID PMC13540018 · OpenAlex W7207612184
Open access: hybrid, a free copy (OpenAlex)
Status: data only
Categories: genetics / omics (modality), mouse (organism), other condition (population), cellular / molecular (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions, Machine learning, Preprocessing
Keywords: tyrosine kinase inhibitors, anxiety, imatinib, prefrontal cortex, metabolomics, sphingolipids
Topic: Chronic Myeloid Leukemia Treatments (Hematology, Medicine), according to OpenAlex
Funding: National Natural Science Foundation of China (NSFC) (82360231); Yunnan Basic Research Program General Project (202401AT070075); Young Scientists Fund for Basic Research of Local Universities in Yunnan Province (202301BA070001-127); Yunnan Provincial Joint Basic Research Project for Local Undergraduate Colleges and Universities (202501BA070001-044); Dali University Undergraduate Research Fund Project (KYSX2024237)
Citations: not cited yet (Europe PMC); 63 references in the paper

Abstract

Background: Anxiety-related symptoms are frequently reported in patients with chronic myeloid leukemia (CML) receiving tyrosine kinase inhibitor (TKI) therapy. However, the role of TKIs, including imatinib, in development of anxiety remains unclear. The prefrontal cortex (PFC) is closely associated with anxiety-like behaviors, and its metabolic components, particularly lipid- and myelin-related metabolites, are involved in their regulation. Whether imatinib affects brain metabolism remains unknown. This study aimed to evaluate the effects of imatinib on anxiety-like behaviors and to investigate associated metabolic alterations in the PFC.

Methods: Anxiety-like behaviors were assessed using a battery of behavioral assays in imatinib-treated mice. PFC tissues from imatinib-treated and control mice were subjected to untargeted metabolomic analysis.

Results: Imatinib-treated mice exhibited selective alterations in anxiety-like behaviors. Metabolomic analysis revealed distinct metabolic profiles between the two groups, with significant changes in lipid-related pathways, particularly sphingolipid metabolism. These findings extend the current understanding of the metabolic basis of anxiety-like behaviors and suggest that TKI treatment may influence neuropsychiatric processes through metabolic remodeling of the PFC.

Conclusions: This study highlights a potential link between TKI therapy and brain metabolism and provides a framework for understanding the neurobiological basis of anxiety-related effects. These findings may inform future research on the neuropsychiatric consequences of targeted cancer therapies.

Reproduced under the paper's license (CC BY), from the paper cited above.

Code

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Data

Datasets cited

Availability of Data and Materials

The datasets generated during the current study have been deposited in Mendeley Data and are publicly available at: https://data.mendeley.com/datasets/6p9vp3vj3d/1.

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 10 authors, 6 keywords, 5 funders, 62 references.

Cite

This paper

Ji, J., Wang, Y., Qu, S., Peng, X., Ma, R., Li, H., Chang, J., Li, L., Li, Y., & Gong, Z. (2026). Imatinib-Induced Changes in Anxiety-Like Behaviors are Associated With Prefrontal Cortical Metabolic Remodeling in Mice. Alpha psychiatry, 27(4), 51694. https://doi.org/10.31083/ap51694

BibTeX

@article{ji2026imatinib,
author = {Ji, Jieyu and Wang, You and Qu, Shanglan and Peng, Xin and Ma, Ruixue and Li, Hanwei and Chang, Jinlong and Li, Lijuan and Li, Yanjiao and Gong, Zhiting},
title = {{Imatinib-Induced Changes in Anxiety-Like Behaviors are Associated With Prefrontal Cortical Metabolic Remodeling in Mice}},
journal = {Alpha psychiatry},
year = {2026},
month = aug,
volume = {27},
number = {4},
pages = {51694},
publisher = {IMR Press},
issn = {2757-8038},
doi = {10.31083/ap51694},
url = {https://doi.org/10.31083/ap51694},
pmid = {42694897},
pmcid = {PMC13540018}
}

RIS

TY - JOUR
AU - Ji, Jieyu
AU - Wang, You
AU - Qu, Shanglan
AU - Peng, Xin
AU - Ma, Ruixue
AU - Li, Hanwei
AU - Chang, Jinlong
AU - Li, Lijuan
AU - Li, Yanjiao
AU - Gong, Zhiting
TI - Imatinib-Induced Changes in Anxiety-Like Behaviors are Associated With Prefrontal Cortical Metabolic Remodeling in Mice
T2 - Alpha psychiatry
J2 - Alpha Psychiatry
PY - 2026
DA - 2026/08/17
VL - 27
IS - 4
SP - 51694
SN - 2757-8038
PB - IMR Press
DO - 10.31083/ap51694
UR - https://doi.org/10.31083/ap51694
LA - en
ER -

CSL-JSON

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