<i>Lactobacillus acidophilus</i> CICC 22162 alleviates sleep deprivation-induced cognitive impairment by remodeling gut microbiota and enhancing S-adenosylmethionine-mediated neuroimmune regulation.
Overview
- School of Medicine, Nanjing University of Chinese Medicine, Nanjing, China
- Huadong Medical Institute of Biotechniques, Nanjing, China
- Department of Infectious Disease, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
- Lushan Rehabilitation and Recuperation Center, Jiujiang, China
- Department of General Surgery, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China
- School of Life Sciences, Xuzhou Medical University, Xuzhou, China
Abstract
Introduction: Sleep deprivation (SD) impairs cognitive function and induces hippocampal injury, yet the gut-derived mechanisms underlying these deficits remain incompletely understood.
Methods: Here, we established a mouse SD model using a modified multiple-platform water environment method and evaluated the effects of oral administration of Lactobacillus acidophilus CICC 22162.
Results: SD caused gut microbial dysbiosis and compromised colonic barrier integrity, leading to hippocampal inflammation, neuronal apoptosis, and synaptic protein loss. Intervention with L. acidophilus CICC 22162 partially restored microbial balance, strengthened intestinal barrier proteins, reduced hippocampal inflammation and neuronal apoptosis, and improved cognitive performance. Fecal microbiota transplantation (FMT) experiments demonstrated that protective effects could be partially transferred via the gut microbiota from treated donors, highlighting the functional role of the intestinal microbial community. Untargeted metabolomics identified S-adenosylmethionine (SAM) as a candidate microbiota-associated metabolite linked to neuroprotection, and in vivo and ex vivo validation showed that SAM reproduced cognitive benefits through α7 nicotinic acetylcholine receptor (α7nAChR)-related signaling, including enhanced JAK2/
Discussion: These findings delineate a gut microbiota–SAM–α7nAChR neuroimmune pathway through which L. acidophilus CICC 22162 alleviates SD-associated cognitive dysfunction, providing mechanistic support for microbiota-targeted interventions against sleep loss-induced cognitive impairment.
Reproduced under the paper's license (CC BY), from the paper cited above.
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- ncbi.nlm.nih.gov/
sra , NCBI; found in “Data availability statement”
Data availability statement
The 16S rRNA amplicon sequencing data presented in this study can be found in the NCBI SRA repository (https://
Reproduced under the paper's license (CC BY), from the paper cited above.
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Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, pages, dates, 10 authors, 8 keywords, 1 funder, 68 references, 26 RRIDs.
Cite
This paper
Jiang, Z., Zhang, Z., Shi, M., Li, X., Zhang, X., Liu, C., Wang, Y., Zhu, J., Gu, C., & Yang, Z. (2026). &
BibTeX
@article{jiang2026lt,
author = {Jiang, Zhiqiang and Zhang, Zhuohan and Shi, Mengqi and Li, Xiaoping and Zhang, Xuefei and Liu, Chang and Wang, Yuhao and Zhu, Jin and Gu, Chunyan and Yang, Zhan},
title = {{\&
journal = {Frontiers in microbiology},
year = {2026},
month = aug,
volume = {17},
pages = {1889475},
publisher = {Frontiers Media SA},
issn = {1664-302X},
doi = {10.3389/
url = {https://
pmid = {42688748},
pmcid = {PMC13536946}
}
RIS
TY - JOUR
AU - Jiang, Zhiqiang
AU - Zhang, Zhuohan
AU - Shi, Mengqi
AU - Li, Xiaoping
AU - Zhang, Xuefei
AU - Liu, Chang
AU - Wang, Yuhao
AU - Zhu, Jin
AU - Gu, Chunyan
AU - Yang, Zhan
TI - &
T2 - Frontiers in microbiology
J2 - Front Microbiol
PY - 2026
DA - 2026/
VL - 17
SP - 1889475
SN - 1664-302X
PB - Frontiers Media SA
DO - 10.3389/
UR - https://
LA - en
ER -
CSL-JSON
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