Systemic proteomic and organ aging signatures associated with plasma Aβ oligomerization in a Korean cohort: a cross-sectional study.
Overview
- PeopleBio Inc., Seongnam-si, Gyeonggi-do, Republic of Korea
- Physiology Department and Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada
- Department of Neurology, Seoul National University Bundang Hospital and Seoul National University College of Medicine, Seongnam-si, Gyeonggi-do, Republic of Korea
- Department of Neurology, Chung-Ang University College of Medicine, Seoul, Republic of Korea
- Department of BionanoTechnology, Gachon University, Seongnam-si, Gyeonggi-do, Republic of Korea
Abstract
Background: Alzheimer’s disease (AD) is characterized by the accumulation of amyloid-beta (Aβ) in the brain, which begins decades before the appearance of clinical symptoms. Blood from AD patients, when spiked with synthetic Aβ, exhibited a higher Aβ oligomerization tendency (OAβT) than the non-AD subjects. OAβT reflected early pathological changes of AD and is considered as a promising blood-based biomarker. However, the mechanism underlying OAβT remained elusive. This study aimed to identify proteomic signatures associated with OAβT and explore its role in AD diagnosis.
Methods: Forty AD and non-AD subjects from a Korean cohort were divided into four groups based on the disease diagnosis, OAβT values (thresholded at 0.78 ng/
Results: Elevated OAβT values, regardless of AD diagnosis, correlated with increased immune response and decreased cellular metabolism. Dementia-predicting proteins were enriched in non-AD individuals with high OAβT. Accelerated muscle aging was associated with high OAβT values and worse cognitive function. Furthermore, several potential pharmacological modulators of OAβT, including Minocycline and Anamorelin, were identified.
Conclusion: Our findings demonstrated OAβT as a reflection of systemic changes linked to early AD pathology. Moreover, the influence of medications and systemic aging on OAβT values pointed to the potential avenues for intervention and emphasized the importance of considering systemic factors in AD pathogenesis and treatment.
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data
Datasets cited
- figshare:31428272, at figshare; found in “Data availability statement”
Data availability statement
The datasets generated and analyzed in this study are publicly available in the FigShare repository and can be accessed at https://
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 1, 30 September 2026: the first record
Recorded: type, language, journal, volume, pages, dates, 10 authors, 5 keywords, 3 funders, 66 references.
Cite
This paper
Oh, H., Kim, H., Kang, H., Kwon, D., French, L., Park, Y. H., Youn, Y. C., An, S. S., Kim, S., & Kang, S. (2026). Systemic proteomic and organ aging signatures associated with plasma Aβ oligomerization in a Korean cohort: a cross-sectional study. Frontiers in aging neuroscience, 18, 1620991. https://
BibTeX
@article{oh2026systemic,
author = {Oh, Hyunjung and Kim, Hongju and Kang, Hojin and Kwon, Dohyeon and French, Leon and Park, Young Ho and Youn, Young Chul and An, Seong Soo and Kim, SangYun and Kang, Sungmin},
title = {{Systemic proteomic and organ aging signatures associated with plasma Aβ oligomerization in a Korean cohort: a cross-sectional study}},
journal = {Frontiers in aging neuroscience},
year = {2026},
month = mar,
volume = {18},
pages = {1620991},
publisher = {Frontiers Media SA},
issn = {1663-4365},
doi = {10.3389/
url = {https://
pmid = {41948065},
pmcid = {PMC13051358}
}
RIS
TY - JOUR
AU - Oh, Hyunjung
AU - Kim, Hongju
AU - Kang, Hojin
AU - Kwon, Dohyeon
AU - French, Leon
AU - Park, Young Ho
AU - Youn, Young Chul
AU - An, Seong Soo
AU - Kim, SangYun
AU - Kang, Sungmin
TI - Systemic proteomic and organ aging signatures associated with plasma Aβ oligomerization in a Korean cohort: a cross-sectional study
T2 - Frontiers in aging neuroscience
J2 - Front Aging Neurosci
PY - 2026
DA - 2026/
VL - 18
SP - 1620991
SN - 1663-4365
PB - Frontiers Media SA
DO - 10.3389/
UR - https://
LA - en
ER -
CSL-JSON
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