Sustained attention in dementia with Lewy bodies: a task-based fMRI study.
Overview
- IRCCS Istituto delle Scienze Neurologiche di Bologna, Functional and Molecular Neuroimaging Unit, Bologna, Italy
- Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy
- IRCCS Istituto delle Scienze Neurologiche di Bologna, U.O.C. Clinica Neurologica Rete Metropolitana (NeuroMet), Bologna, Italy
- IRCCS Istituto delle Scienze Neurologiche di Bologna, Programma di Neurogenetica, Bologna, Italy
- Department of Medicine and Surgery, University of Parma, Parma, Italy
- Department of Neuroscience, University of Sheffield, Sheffield, United Kingdom
Abstract
Introduction: Patients with Dementia with Lewy Bodies (DLB) typically experience attentional deficits. Understanding these deficits and the underlying neural correlates is crucial as sustained attention supports higher level cognitive functions. The objective of this study was to investigate the patterns of brain connectivity during a functional magnetic resonance imaging (fMRI) sustained attention task in a DLB group compared with healthy controls (HC).
Methods: In this study, 30 DLB patients and 25 HC underwent a comprehensive neuropsychological assessment and a brain 3T MRI protocol that included a high-resolution structural sequence (T1-w 3D MPRAGE) and a task-based fMRI study using an auditory Psychomotor Vigilance Task (PVT).
Results: DLB patients performed worse in neuropsychological tests mainly related to the visuospatial domain and had poorer performance than HC on sustained attention (i.e., PVT) in terms of lapses and longer response times. Moreover, during the PVT, the DLB group exhibited significantly lower activation in the precuneus, intracalcarine cortex, angular gyrus and cuneus, regions implicated in sustained attention.
Discussion: Overall, the identification of a distinct pattern of brain activity related to attention impairment in DLB patients offers opportunities for the development of tailored cognitive stimulation treatments.
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data
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collections/ , at neurovault.org; found in the end of the paper262
Data availability statement
The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 2, 28 September 2026
- Funding: added European Commission: 11-10-2022, 15.03.2022, PE0000006, D93C22000930002, CUP D93C22000930002; Ministero della Salute: 10/2022, PE0000006, CUP D93C22000930002
Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, pages, dates, 13 authors, 5 keywords, 80 references.
Cite
This paper
Braghittoni, D., Venturi, G., Guidi, L., Capogna, E., Sighinolfi, G., Baldelli, L., Amore, G., La Morgia, C., Sambati, L., Venneri, A., Lodi, R., Tonon, C., & Mitolo, M. (2026). Sustained attention in dementia with Lewy bodies: a task-based fMRI study. Frontiers in aging neuroscience, 18, 1822185. https://
BibTeX
@article{braghittoni2026
author = {Braghittoni, Davide and Venturi, Greta and Guidi, Lucia and Capogna, Elettra and Sighinolfi, Giovanni and Baldelli, Luca and Amore, Giulia and La Morgia, Chiara and Sambati, Luisa and Venneri, Annalena and Lodi, Raffaele and Tonon, Caterina and Mitolo, Micaela},
title = {{Sustained attention in dementia with Lewy bodies: a task-based fMRI study}},
journal = {Frontiers in aging neuroscience},
year = {2026},
month = jun,
volume = {18},
pages = {1822185},
publisher = {Frontiers Media SA},
issn = {1663-4365},
doi = {10.3389/
url = {https://
pmid = {42358605},
pmcid = {PMC13290862}
}
RIS
TY - JOUR
AU - Braghittoni, Davide
AU - Venturi, Greta
AU - Guidi, Lucia
AU - Capogna, Elettra
AU - Sighinolfi, Giovanni
AU - Baldelli, Luca
AU - Amore, Giulia
AU - La Morgia, Chiara
AU - Sambati, Luisa
AU - Venneri, Annalena
AU - Lodi, Raffaele
AU - Tonon, Caterina
AU - Mitolo, Micaela
TI - Sustained attention in dementia with Lewy bodies: a task-based fMRI study
T2 - Frontiers in aging neuroscience
J2 - Front Aging Neurosci
PY - 2026
DA - 2026/
VL - 18
SP - 1822185
SN - 1663-4365
PB - Frontiers Media SA
DO - 10.3389/
UR - https://
LA - en
ER -
CSL-JSON
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