Regional gene expression and brain atrophy in dementia with Lewy bodies: an imaging transcriptomics study.
Overview
16 affiliations
- Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden
- University Hospital of Psychiatry and Psychotherapy Bern, University of Bern, Bern, Switzerland
- Vrije Universiteit Amsterdam, Amsterdam, Netherlands
- Department of Radiology, Mayo Clinic, Rochester, MN USA
- Quantitative Health Sciences, Mayo Clinic, Rochester, MN USA
- Department of Electrical Engineering and Computer Science, University of Stavanger, Stavanger, Norway
- Day Hospital of Geriatrics, Memory Resource and Research Centre (CM2R) of Strasbourg, Department of Geriatrics, Hopitaux Universitaires de Strasbourg, Strasbourg, France
- ICube Laboratory and Federation de Medecine Translationnelle de Strasbourg (FMTS), University of Strasbourg and French National Centre for Scientific Research (CNRS), Team Imagerie Multimodale Integrative en Sante (IMIS)/ICONE, Strasbourg, France
- Amsterdam Alzheimer Center, Department of Neurology, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam, Netherlands
- Memory Clinic, Department of Neurology, Charles University, Second Faculty of Medicine and Motol University Hospital, Prague, Czech Republic
- Department of Neurology, Mayo Clinic, Rochester, MN USA
- Department of Old Age Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK
- Center for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway
- Department of Anatomy and Neurosciences, Section Clinical Neuroanatomy and Biobanking, Amsterdam UMC, Amsterdam, Netherlands
- Amsterdam Neuroscience, Brain Imaging, Amsterdam, Netherlands
- Department of Psychology, Faculty of Health Sciences, University Fernando Pessoa Canarias, Las Palmas, Spain
Abstract
Regional brain atrophy has been observed in dementia with Lewy bodies (DLB), yet determinants of regional vulnerability remain unclear. Using imaging transcriptomics, we examined whether normative gene expression patterns relate to regional atrophy in DLB. We included 164 DLB patients (49 women) and 164 age- and sex-matched healthy controls from three European centres and the Mayo Clinic, USA. Volumetric atrophy was quantified from T1-weighted MRI across 58 left-hemispheric regions using w-scores. Normative expression of twelve genes implicated in alpha-synuclein, beta-amyloid, and tau pathology was extracted from the Allen Human Brain Atlas. DLB patients showed diffuse atrophy across most regions. In the full cohort, normative expression of MAPT, PINK1, and PSEN2 predicted regional atrophy after correction for spatial autocorrelation, although none survived multiple-testing correction. In the Mayo Clinic sub-cohort, expression of APP, BIN1, GBA, MAPT, PINK1, SNCA, and TMEM175 significantly predicted atrophy and survived multiple-testing correction. Random forest models did not outperform spatial null models in the full cohort, but PARK7, PINK1, and PSEN2 consistently emerged as important predictors. A significant global model was observed in the Mayo Clinic sub-cohort, driven by GBA, LRP1, and PINK1. These findings suggest that normative gene expression partially contributes to regional brain atrophy in DLB.
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
The paper says that its authors' code is available on request: it was not published with the paper, so there is nothing to verify.
Code availability
The underlying code for this study is not publicly available but may be made available to qualified researchers upon request to the corresponding author.
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data
No dataset and no data link were found in the paper.
Data availability
The MRI data that support the findings of this study are available through the E-DLB consortium (https://
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 1, 29 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 16 authors, 4 keywords, 1 funder, 73 references.
Cite
This paper
Habich, A., Baumann, J. M., Schwarz, C. G., Przybelski, S. A., Inguanzo, A., Oppedal, K., Blanc, F., Lemstra, A. W., Hort, J., Boeve, B. F., Aarsland, D., Westman, E., Dierks, T., Kantarci, K., Jonkman, L. E., & Ferreira, D. (2026). Regional gene expression and brain atrophy in dementia with Lewy bodies: an imaging transcriptomics study. NPJ Parkinson's disease, 12(1), 96. https://
BibTeX
@article{habich2026regio
author = {Habich, Annegret and Baumann, Janna M and Schwarz, Christopher G and Przybelski, Scott A and Inguanzo, Anna and Oppedal, Ketil and Blanc, Frédéric and Lemstra, Afina W and Hort, Jakub and Boeve, Bradley F and Aarsland, Dag and Westman, Eric and Dierks, Thomas and Kantarci, Kejal and Jonkman, Laura E and Ferreira, Daniel},
title = {{Regional gene expression and brain atrophy in dementia with Lewy bodies: an imaging transcriptomics study}},
journal = {NPJ Parkinson's disease},
year = {2026},
month = apr,
volume = {12},
number = {1},
pages = {96},
publisher = {Nature Publishing Group},
issn = {2373-8057},
doi = {10.1038/
url = {https://
pmid = {41991538},
pmcid = {PMC13087014}
}
RIS
TY - JOUR
AU - Habich, Annegret
AU - Baumann, Janna M
AU - Schwarz, Christopher G
AU - Przybelski, Scott A
AU - Inguanzo, Anna
AU - Oppedal, Ketil
AU - Blanc, Frédéric
AU - Lemstra, Afina W
AU - Hort, Jakub
AU - Boeve, Bradley F
AU - Aarsland, Dag
AU - Westman, Eric
AU - Dierks, Thomas
AU - Kantarci, Kejal
AU - Jonkman, Laura E
AU - Ferreira, Daniel
TI - Regional gene expression and brain atrophy in dementia with Lewy bodies: an imaging transcriptomics study
T2 - NPJ Parkinson's disease
J2 - NPJ Parkinsons Dis
PY - 2026
DA - 2026/
VL - 12
IS - 1
SP - 96
SN - 2373-8057
PB - Nature Publishing Group
DO - 10.1038/
UR - https://
LA - en
ER -
CSL-JSON
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