Stereoselective effects of nicotine enantiomers on the gut-brain axis and neuroinflammation in a mouse model of Parkinson's disease.
Overview
- Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, China
- University of Science and Technology of China, Hefei, China
- Beijing Life Science Academy, Beijing, China
- Key Laboratory of Tobacco Biological Effects, China National Tobacco Quality Supervision & Test Center, Zhengzhou, China
Abstract
Introduction: Parkinson’s disease (PD) is characterized by progressive dopaminergic neurodegeneration, neuroinflammation, and emerging evidence of gut microbiota dysbiosis. Although nicotine has been implicated in neuroprotection, whether its enantiomers exert stereoselective effects on the gut-brain axis remains unknown.
Methods: We systematically compared the effects of S-nicotine and R-nicotine in an MPTP-induced mouse model of PD. Motor function, nigrostriatal dopaminergic neuronal loss, neuroinflammatory responses, intestinal barrier integrity, and gut microbiota composition were assessed.
Results: Both enantiomers ameliorated motor deficits, attenuated nigrostriatal dopaminergic neuronal loss, and suppressed neuroinflammatory responses, yet exhibited markedly different efficacy profiles. S-nicotine produced robust neuroprotection at a lower effective dose (1 mg/
Discussion: These findings demonstrate pronounced stereoselective and dose-dependent effects of nicotine enantiomers on neuroimmune modulation and identify gut microbiota remodeling as a functionally relevant correlate of nicotine-mediated neuroprotection in PD. Our results highlight the therapeutic potential of targeting the microbiota-gut-brain axis through chiral interventions and support S-nicotine as a promising candidate for neuroprotective strategies in aging-related neurodegenerative disorders.
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data
Datasets cited
- bioproject:PRJNA1398440, at NCBI BioProject; found in “Data availability statement”
Data availability statement
The datasets presented in this study are available in online repositories. The raw 16S rRNA sequencing data have been deposited in the NCBI BioProject database under accession number PRJNA1398440 (https://
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 2, 28 September 2026
- Funding: added National Natural Science Foundation of China
Version 1, 28 September 2026: the first record
Recorded: type, language, journal, volume, pages, dates, 10 authors, 8 keywords, 55 references.
Cite
This paper
Liu, R., Ma, Y., Li, Y., Gao, X., Wang, S., Xu, L., Liu, G., Chen, H., Ji, M., & Hou, H. (2026). Stereoselective effects of nicotine enantiomers on the gut-brain axis and neuroinflammation in a mouse model of Parkinson's disease. Frontiers in aging neuroscience, 18, 1823372. https://
BibTeX
@article{liu2026stereose
author = {Liu, Ruixia and Ma, Yunu and Li, Yingyan and Gao, Xia and Wang, Shu and Xu, Lutao and Liu, Guanglin and Chen, Huan and Ji, Min and Hou, Hongwei},
title = {{Stereoselective effects of nicotine enantiomers on the gut-brain axis and neuroinflammation in a mouse model of Parkinson's disease}},
journal = {Frontiers in aging neuroscience},
year = {2026},
month = may,
volume = {18},
pages = {1823372},
publisher = {Frontiers Media SA},
issn = {1663-4365},
doi = {10.3389/
url = {https://
pmid = {42212003},
pmcid = {PMC13212218}
}
RIS
TY - JOUR
AU - Liu, Ruixia
AU - Ma, Yunu
AU - Li, Yingyan
AU - Gao, Xia
AU - Wang, Shu
AU - Xu, Lutao
AU - Liu, Guanglin
AU - Chen, Huan
AU - Ji, Min
AU - Hou, Hongwei
TI - Stereoselective effects of nicotine enantiomers on the gut-brain axis and neuroinflammation in a mouse model of Parkinson's disease
T2 - Frontiers in aging neuroscience
J2 - Front Aging Neurosci
PY - 2026
DA - 2026/
VL - 18
SP - 1823372
SN - 1663-4365
PB - Frontiers Media SA
DO - 10.3389/
UR - https://
LA - en
ER -
CSL-JSON
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