An end-to-end pipeline for automated fetal brain segmentation and biometry from 3D SSFP MRI.
The 13 matches
- [1] § Materials and methods › Pipeline overview ↔ head_seg/entire_pipeline.py, lines 1–30 · score 0.77 · end pipeline, extraaxial CSF, brain segmentation, brain parenchyma, head circumference, biometry
- [2] § Experimental results and discussion › Failure case analysis ↔ head_seg/entire_pipeline.py, lines 1–30 · score 0.71 · automated fetal brain, entire pipeline, SSFP MRI, head circumference, Tri Attention, biometry
- [3] § Materials and methods › Proposed model architecture ↔ brain_seg/triatt.py, lines 174–214 · score 0.64 · SE block, decoder blocks, encoder block, deep supervision, bottleneck, ECA
- [4] § Materials and methods › Proposed model architecture ↔ head_seg/triatt.py, lines 174–214 · score 0.64 · SE block, decoder blocks, encoder block, deep supervision, bottleneck, ECA
- [5] § Materials and methods › Implementation, experiments and evaluation metrics ↔ nnUNet-master/nnunetv2/training/loss/compound_losses.py, lines 8–56 · score 0.63 · cross entropy loss, Dice loss, weighting, masks, class
- [6] § Materials and methods › Implementation, experiments and evaluation metrics ↔ head_seg/metrics.py, lines 38–61 · score 0.60 · Focal loss, cross entropy, metrics, predictions
- [7] § Materials and methods › Implementation, experiments and evaluation metrics ↔ brain_seg/eval_diff_methods.py, lines 114–174 · score 0.60 · Hausdorff distance, MONAI, PyTorch, batch, precision, sensitivity
- [8] § Materials and methods › Head circumference algorithm › Elliptical fitting ↔ head_seg/entire_pipeline.py, lines 110–136 · score 0.58 · fitted ellipse, head circumference, axis, slice
- [9] § Experimental results and discussion › Head segmentation model results ↔ head_seg/ablation.py, lines 276–356 · score 0.53 · Shapiro Wilk, Bonferroni correction, metrics, head, model
- [10] § Materials and methods › Implementation, experiments and evaluation metrics ↔ nnUNet-master/nnunetv2/imageio/base_reader_writer.py, lines 21–107 · score 0.53 · voxel spacing, predicted segmentation, dimensions, resampled, axis
- [11] § Materials and methods › Implementation, experiments and evaluation metrics ↔ nnUNet-master/nnunetv2/training/nnUNetTrainer/nnUNetTrainer.py, lines 1020–1085 · score 0.52 · predicted segmentation, TN, FP, TP, FN, PyTorch
- [12] § Materials and methods › Proposed model architecture ↔ head_seg/triatt_nnet.py, lines 177–224 · score 0.51 · encoder block, deep supervision, bottleneck, ECA, SE, ASPP
- [13] § Materials and methods › Proposed model architecture ↔ brain_seg/triatt.py, lines 174–214 · score 0.51 · encoder block, deep supervision, bottleneck, ECA, SE, ASPP
Paper
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The authors' code
Python · 363 lines · 12 KB · no license · 3 matches
- #!/usr/bin/env python3
- """
- End-to-end fetal brain segmentation and biometry pipeline.
- Stages:
- 1. Head localization (Tri-Attention nnU-Net)
- 2. Head circumference estimation (ellipse fitting)
- 3. Brain parenchyma + extraaxial CSF segmentation (nnU-Net)
- Associated publication:
- An end-to-end pipeline for automated
- fetal brain segmentation and biometry from 3D SSFP MRI.
- Frontiers in Neuroscience (2026). doi:10.3389/fnins.2026.1870124
- """
- from __future__ import annotations
- import argparse
- import json
- import math
- import os
- import sys
- import time
- from pathlib import Path
- import cv2
- import nibabel as nib
- import numpy as np
- import torch
- from nnunetv2.inference.predict_from_raw_data import nnUNetPredictor
- # Ensure project root is on path for config import
- PROJECT_ROOT = Path(__file__).resolve().parent.parent
- sys.path.insert(0, str(PROJECT_ROOT))
- import config
- DEFAULT_HEAD_MODEL_PATH = Path(config.HEAD_MODEL_PATH)
- DEFAULT_BRAIN_MODEL_PATH = Path(config.BRAIN_MODEL_PATH)
- NUM_CLASSES = 3
- CLASS_NAMES = ["background", "brain", "extraaxial_csf"]
- DEVICE = "cuda" if torch.cuda.is_available() and config.DEVICE != "cpu" else "cpu"
- def load_nifti(path: str | Path) -> tuple[np.ndarray, tuple[float, float, float]]:
- """Load a NIfTI volume and return (data, spacing)."""
- path = str(path)
- try:
- img = nib.load(path)
- except nib.filebasedimages.ImageFileError:
- import shutil
- import tempfile
- tmp = tempfile.NamedTemporaryFile(suffix=".nii", delete=False)
- with open(path, "rb") as f_in:
- shutil.copyfileobj(f_in, tmp)
- tmp.close()
- img = nib.load(tmp.name)
- data = img.get_fdata()
- spacing = img.header.get_zooms()[:3]
- os.remove(tmp.name)
- return data, spacing
- return img.get_fdata(), img.header.get_zooms()[:3]
- def save_nifti(data: np.ndarray, reference_path: str | Path, output_path: str | Path) -> None:
- ref = nib.load(str(reference_path))
- out = nib.Nifti1Image(data.astype(np.float32), ref.affine, ref.header)
- Path(output_path).parent.mkdir(parents=True, exist_ok=True)
- nib.save(out, str(output_path))
- def crop_to_head_roi(image: np.ndarray, head_pred: np.ndarray, margin: int = 10):
- coords = np.argwhere(head_pred > 0)
- if coords.shape[0] == 0:
- return image, None
- z_min, y_min, x_min = coords.min(axis=0)
- z_max, y_max, x_max = coords.max(axis=0)
- z_min = max(z_min - margin, 0)
- y_min = max(y_min - margin, 0)
- x_min = max(x_min - margin, 0)
- z_max = min(z_max + margin, image.shape[1])
- y_max = min(y_max + margin, image.shape[2])
- x_max = min(x_max + margin, image.shape[3])
- cropped = image[:, z_min:z_max, y_min:y_max, x_min:x_max]
- bbox = (z_min, z_max, y_min, y_max, x_min, x_max)
- return cropped, bbox
- def restore_to_full(seg_cropped: np.ndarray, bbox, original_shape: tuple) -> np.ndarray:
- if bbox is None:
- return seg_cropped
- full = np.zeros(original_shape, dtype=seg_cropped.dtype)
- z_min, z_max, y_min, y_max, x_min, x_max = bbox
- full[z_min:z_max, y_min:y_max, x_min:x_max] = seg_cropped
- return full
- def ellipse_circumference(a: float, b: float) -> float:
- """Ramanujan's second approximation for ellipse perimeter."""
- h = ((a - b) ** 2) / ((a + b) ** 2)
- return math.pi * (a + b) * (1 + (3 * h) / (10 + math.sqrt(4 - 3 * h)))
- def compute_head_circumference(head_pred_3d: np.ndarray, spacing) -> float | None:
- best_area = 0
- best_slice = None
- for i in range(head_pred_3d.shape[0]):
- slc = (head_pred_3d[i] > 0).astype(np.uint8)
- area = np.count_nonzero(slc)
- if area > best_area:
- best_area = area
- best_slice = slc
- if best_slice is None or best_area == 0:
- return None
- contours, _ = cv2.findContours(best_slice, cv2.RETR_EXTERNAL, cv2.CHAIN_APPROX_NONE)
- if not contours:
- return None
- largest = max(contours, key=cv2.contourArea)
- if len(largest) < 5:
- return None
- (center, axes, _angle) = cv2.fitEllipse(largest)
- _cx, _cy = center
- axis_major, axis_minor = axes
- a = (axis_major / 2) * spacing[1]
- b = (axis_minor / 2) * spacing[2]
- return ellipse_circumference(a, b)
- def build_predictors(
- head_model_path: str,
- brain_model_path: str,
- head_checkpoint: str = "checkpoint_final.pth",
- brain_checkpoint: str = "checkpoint_final.pth",
- ):
- head_predictor = nnUNetPredictor(
- tile_step_size=0.5,
- use_gaussian=True,
- use_mirroring=True,
- perform_everything_on_device=(DEVICE == "cuda"),
- device=torch.device(DEVICE),
- )
- head_predictor.initialize_from_trained_model_folder(
- head_model_path, use_folds=(0,), checkpoint_name=head_checkpoint
- )
- brain_predictor = nnUNetPredictor(
- tile_step_size=0.5,
- use_gaussian=True,
- use_mirroring=True,
- perform_everything_on_device=(DEVICE == "cuda"),
- device=torch.device(DEVICE),
- )
- brain_predictor.initialize_from_trained_model_folder(
- brain_model_path, use_folds=(0,), checkpoint_name=brain_checkpoint
- )
- return head_predictor, brain_predictor
- def run_full_pipeline(
- nifti_path: str | Path,
- head_predictor: nnUNetPredictor,
- brain_predictor: nnUNetPredictor,
- ) -> dict:
- img, spacing = load_nifti(nifti_path)
- img = img[None].astype(np.float32)
- properties = {"spacing": list(spacing)}
- if DEVICE == "cuda":
- torch.cuda.reset_peak_memory_stats()
- torch.cuda.synchronize()
- start = time.time()
- head_pred = head_predictor.predict_single_npy_array(img, properties, None, None, False)
- hc_mm = compute_head_circumference(head_pred, spacing)
- cropped_img, bbox = crop_to_head_roi(img, head_pred, margin=10)
- seg_pred_crop = brain_predictor.predict_single_npy_array(
- cropped_img, properties, None, None, False
- )
- seg_pred = restore_to_full(seg_pred_crop, bbox, head_pred.shape)
- if DEVICE == "cuda":
- torch.cuda.synchronize()
- elapsed = time.time() - start
- peak_mem = (
- torch.cuda.max_memory_allocated() / (1024**3) if DEVICE == "cuda" else None
- )
- return {
- "head_mask": head_pred,
- "segmentation": seg_pred,
- "head_circumference_mm": hc_mm,
- "inference_time_sec": elapsed,
- "peak_gpu_memory_gb": peak_mem,
- "spacing": spacing,
- }
- def collect_inputs(input_path: Path) -> list[Path]:
- if input_path.is_file():
- return [input_path]
- if input_path.is_dir():
- files = sorted(input_path.glob("*.nii.gz")) + sorted(input_path.glob("*.nii"))
- return files
- raise FileNotFoundError(f"Input path not found: {input_path}")
- def parse_args() -> argparse.Namespace:
- parser = argparse.ArgumentParser(
- description="Fetal brain segmentation and biometry pipeline (SSFP MRI)"
- )
- parser.add_argument(
- "--input",
- type=Path,
- default=Path(config.INFERENCE_INPUT_DIR),
- help="Input NIfTI file or directory of volumes",
- )
- parser.add_argument(
- "--output",
- type=Path,
- default=Path(config.OUTPUT_DIR),
- help="Directory for segmentation outputs and summary JSON",
- )
- parser.add_argument(
- "--head-model",
- type=Path,
- default=DEFAULT_HEAD_MODEL_PATH,
- help=f"Path to trained head segmentation nnU-Net model folder (default: {DEFAULT_HEAD_MODEL_PATH})",
- )
- parser.add_argument(
- "--brain-model",
- type=Path,
- default=DEFAULT_BRAIN_MODEL_PATH,
- help=f"Path to trained brain segmentation nnU-Net model folder (default: {DEFAULT_BRAIN_MODEL_PATH})",
- )
- parser.add_argument(
- "--head-checkpoint",
- type=str,
- default="checkpoint_final.pth",
- help="Checkpoint filename inside fold_0/ for the head model (e.g. checkpoint_best.pth)",
- )
- parser.add_argument(
- "--brain-checkpoint",
- type=str,
- default="checkpoint_final.pth",
- help="Checkpoint filename inside fold_0/ for the brain model (e.g. checkpoint_best.pth)",
- )
- parser.add_argument(
- "--gt-dir",
- type=Path,
- default=None,
- help="Optional ground-truth labels directory for evaluation",
- )
- return parser.parse_args()
- def main() -> None:
- args = parse_args()
- gt_dir = args.gt_dir or (Path(config.INFERENCE_GT_DIR) if config.INFERENCE_GT_DIR else None)
- if not args.head_model.exists():
- sys.exit(f"Head model not found: {args.head_model}")
- if not args.brain_model.exists():
- sys.exit(f"Brain model not found: {args.brain_model}")
- args.output.mkdir(parents=True, exist_ok=True)
- inputs = collect_inputs(args.input)
- if not inputs:
- sys.exit(f"No NIfTI files found in {args.input}")
- print(f"Device: {DEVICE}")
- print(f"Loading models from:\n Head: {args.head_model}\n Brain: {args.brain_model}")
- head_predictor, brain_predictor = build_predictors(
- str(args.head_model),
- str(args.brain_model),
- head_checkpoint=args.head_checkpoint,
- brain_checkpoint=args.brain_checkpoint,
- )
- results = []
- for nifti_path in inputs:
- case_id = nifti_path.name.replace("_0000.nii.gz", "").replace("_0000.nii", "")
- case_id = case_id.replace(".nii.gz", "").replace(".nii", "")
- out = run_full_pipeline(nifti_path, head_predictor, brain_predictor)
- head_out = args.output / f"{case_id}_head_mask.nii.gz"
- seg_out = args.output / f"{case_id}_brain_seg.nii.gz"
- save_nifti(out["head_mask"], nifti_path, head_out)
- save_nifti(out["segmentation"], nifti_path, seg_out)
- hc = out["head_circumference_mm"]
- hc_str = f"{hc:.2f} mm" if hc is not None else "N/A"
- print(
- f"{nifti_path.name} → time: {out['inference_time_sec']:.2f}s | "
- f"head circumference: {hc_str}"
- )
- entry = {
- "case_id": case_id,
- "input": str(nifti_path),
- "head_mask": str(head_out),
- "segmentation": str(seg_out),
- "head_circumference_mm": None if hc is None else float(hc),
- "inference_time_sec": float(out["inference_time_sec"]),
- "peak_gpu_memory_gb": (
- None
- if out["peak_gpu_memory_gb"] is None
- else float(out["peak_gpu_memory_gb"])
- ),
- }
- if gt_dir and gt_dir.exists():
- gt_path = gt_dir / f"{case_id}.nii.gz"
- if not gt_path.exists():
- gt_path = gt_dir / f"{case_id}.nii"
- if gt_path.exists():
- gt, _ = load_nifti(gt_path)
- pred = out["segmentation"]
- if pred.ndim > 3:
- pred = np.squeeze(pred)
- if gt.ndim > 3:
- gt = np.squeeze(gt)
- entry["metrics"] = {
- cname: {
- "dice": float(
- 2 * np.sum((pred == c) & (gt == c))
- / (np.sum(pred == c) + np.sum(gt == c) + 1e-8)
- )
- for cname, c in zip(CLASS_NAMES, range(NUM_CLASSES))
- }
- }
- results.append(entry)
- summary_path = args.output / "pipeline_summary.json"
- with open(summary_path, "w", encoding="utf-8") as f:
- json.dump(results, f, indent=2)
- times = [r["inference_time_sec"] for r in results]
- print("\n" + "=" * 60)
- print("PIPELINE SUMMARY")
- print("=" * 60)
- print(f"Cases processed: {len(results)}")
- print(f"Avg inference time: {np.mean(times):.2f} ± {np.std(times):.2f} sec")
- valid_hc = [r["head_circumference_mm"] for r in results if r["head_circumference_mm"]]
- if valid_hc:
- print(f"Avg head circumference: {np.mean(valid_hc):.2f} ± {np.std(valid_hc):.2f} mm")
- print(f"Results saved to: {args.output}")
- print(f"Summary JSON: {summary_path}")
- if __name__ == "__main__":
- main()
entire_pipeline.py at commit 781b0ac, no license · at the source
Overview
- Department of Electrical, Computer and Biomedical Engineering, Faculty of Engineering and Architectural Sciences, Toronto Metropolitan University, Toronto, ON, Canada
- Institute for Biomedical Engineering, Science and Technology (iBEST), Toronto Metropolitan University and St. Michael’s Hospital, Toronto, ON, Canada
- Division of Neuroradiology, Department of Diagnostic & Interventional Radiology, The Hospital for Sick Children, Toronto, ON, Canada
- Institute of Diagnostic and Interventional Neuroradiology, University Hospital Augsburg, Augsburg, Germany
- Neurosciences & Mental Health Program, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada
- Department of Medical Imaging, University of Toronto, Toronto, ON, Canada
- Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
Abstract
Fetal magnetic resonance imaging (MRI) plays an essential role for the evaluation of fetal abnormalities, offering improved visualization of developing brain structures and superior soft tissue contrast in comparison to other imaging modalities. Accurate and reproducible assessment of fetal brain biometry is critical for diagnosing neurodevelopmental abnormalities. However, these measurements typically rely on manual segmentation, which is time-consuming, labor-intensive, prone to error and dependent on the interpreting radiologist’s expertise and experience. Recent advancements have enabled automated analysis primarily on Half-Fourier Acquisition Single-shot Turbo spin-Echo (HASTE) sequences, yet these acquisitions are susceptible to inter-slice misalignment and often require time-consuming super-resolution reconstruction. In contrast, 3D Steady-State Free Precession (SSFP) imaging offers smaller slice thickness, improving through-plane resolution, along with reduced motion sensitivity and whole-body coverage in a single scan. In this study, we present an end-to-end deep learning pipeline for automated segmentation and biometry of the fetal brain from whole-body SSFP MRI. The dataset includes manual annotations of the fetal head, brain parenchyma and extraaxial cerebrospinal fluid (CSF). The framework employs nnU-Net for robust head localization and multi-structure segmentation, along with principal component analysis (PCA)-based reorientation and head circumference estimation. A Tri-Attention U-Net architecture was evaluated as a standalone model and within the nnU-Net framework. The final pipeline consists of a Tri-Attention nnU-Net for head localization and nnU-Net for multi-structure segmentation. The pipeline achieved mean Dice similarity coefficients (DSC) of 94.48, 93.58 and 82.75% for the head, brain parenchyma and extraaxial CSF, respectively. These findings demonstrate the feasibility of accurate, fully automated fetal brain biometry from SSFP MRI with potential to reduce inter-observer variability, streamline clinical workflows and enhance clinical decision-making through fast and reproducible quantitative assessment.
Reproduced under the paper's license (CC BY), from the paper cited above.
Repository
Its files are read in the Code ↔ Paper reader above, with 13 matches between paragraphs and lines of code.
DrSussmanLab/fetal-brain-seg
781b0ac7e03f1aa5c36479e288eb2116d64fd704, 9 July 2026Availability: 1 check, the latest on 27 September 2026: the link answers
- 27 September 2026: the link answers
229 files
- brain_seg/
eval_diff_methods.py , Python, 487 lines, 1 match - brain_seg/
eval_nnunet.py , Python, 233 lines - brain_seg/
eval_nnunettri.py , Python, 64 lines - brain_seg/
eval_nnunettri_2.py , Python, 312 lines - brain_seg/
metrics.py , Python, 61 lines - brain_seg/
models.py , Python, 76 lines - brain_seg/
nnunet_setup.py , Python, 115 lines - brain_seg/
preprocess.py , Python, 125 lines - brain_seg/
train.py , Python, 385 lines - brain_seg/
triatt.py , Python, 215 lines, 2 matches - config.py, Python, 107 lines
- head_seg/
ablation.py , Python, 619 lines, 1 match - head_seg/
entire_pipeline.py , Python, 363 lines, 3 matches - head_seg/
eval_diff_methods.py , Python, 716 lines - head_seg/
evaluation_delete.py , Python, 511 lines - head_seg/
evaluation_diff_methods. , Python, 275 linespy - head_seg/
metrics.py , Python, 94 lines, 1 match - head_seg/
models.py , Python, 76 lines - head_seg/
nnunet_eval.py , Python, 135 lines - head_seg/
preprocess.py , Python, 108 lines - head_seg/
preprocess_nnunet.py , Python, 98 lines - head_seg/
train.py , Python, 360 lines - head_seg/
triatt.py , Python, 214 lines, 1 match - head_seg/
triatt_nnet.py , Python, 224 lines, 1 match - nnUNet-master/
documentation/ , Python, 1 line__init__.py - nnUNet-master/
documentation/ , Python, 1 linecompetitions/ FLARE24/ Task_1/ __init__.py - nnUNet-master/
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documentation/ , Python, 1 linecompetitions/ FLARE24/ __init__.py - nnUNet-master/
documentation/ , Python, 1 linecompetitions/ Toothfairy2/ __init__.py - nnUNet-master/
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nnunetv2/ , Python, 113 linesbatch_running/ release_trainings/ nnunetv2_v1/ collect_results.py - nnUNet-master/
nnunetv2/ , Python, 93 linesbatch_running/ release_trainings/ nnunetv2_v1/ generate_lsf_commands.py - nnUNet-master/
nnunetv2/ , Python, 10 linesconfiguration.py - nnUNet-master/
nnunetv2/ , Python, 147 linesdataset_conversion/ Dataset015_018_RibFrac_R ibSeg.py - nnUNet-master/
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nnunetv2/ , Python, 110 linesdataset_conversion/ Dataset042_BraTS18.py - nnUNet-master/
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nnunetv2/ , Python, 198 linesdataset_conversion/ Dataset114_MNMs.py - nnUNet-master/
nnunetv2/ , Python, 61 linesdataset_conversion/ Dataset115_EMIDEC.py - nnUNet-master/
nnunetv2/ , Python, 196 linesdataset_conversion/ Dataset119_ToothFairy2_A ll.py - nnUNet-master/
nnunetv2/ , Python, 87 linesdataset_conversion/ Dataset120_RoadSegmentat ion.py - nnUNet-master/
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nnunetv2/ , Python, 70 linesdataset_conversion/ Dataset221_AutoPETII_202 3.py - nnUNet-master/
nnunetv2/ , Python, 59 linesdataset_conversion/ Dataset223_AMOS2022postC hallenge.py - nnUNet-master/
nnunetv2/ , Python, 60 linesdataset_conversion/ Dataset224_AbdomenAtlas1 .0.py - nnUNet-master/
nnunetv2/ , Python, 55 linesdataset_conversion/ Dataset226_BraTS2024-Bra TS-GLI.py - nnUNet-master/
nnunetv2/ , Python, 56 linesdataset_conversion/ Dataset227_TotalSegmenta torMRI.py - nnUNet-master/
nnunetv2/ , Python, 32 linesdataset_conversion/ Dataset987_dummyDataset4 .py - nnUNet-master/
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setup.py , Python, 4 lines - scripts/
entrypoint.sh , Shell, 80 lines - README.md, Text, 421 lines
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Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, pages, dates, 8 authors, 7 keywords, 1 funder, 32 references.
Cite
This paper
Modarai, Y., Lim, A., Lo, J., Wagner, M. W., Miller, E., Vidarsson, L., Ertl-Wagner, B., & Sussman, D. (2026). An end-to-end pipeline for automated fetal brain segmentation and biometry from 3D SSFP MRI. Frontiers in neuroscience, 20, 1870124. https://
BibTeX
@article{modarai2026end,
author = {Modarai, Yasmin and Lim, Adam and Lo, Justin and Wagner, Matthias W. and Miller, Elka and Vidarsson, Logi and Ertl-Wagner, Birgit and Sussman, Dafna},
title = {{An end-to-end pipeline for automated fetal brain segmentation and biometry from 3D SSFP MRI}},
journal = {Frontiers in neuroscience},
year = {2026},
month = jul,
volume = {20},
pages = {1870124},
publisher = {Frontiers Media SA},
issn = {1662-4548},
doi = {10.3389/
url = {https://
pmid = {42495270},
pmcid = {PMC13391945}
}
RIS
TY - JOUR
AU - Modarai, Yasmin
AU - Lim, Adam
AU - Lo, Justin
AU - Wagner, Matthias W.
AU - Miller, Elka
AU - Vidarsson, Logi
AU - Ertl-Wagner, Birgit
AU - Sussman, Dafna
TI - An end-to-end pipeline for automated fetal brain segmentation and biometry from 3D SSFP MRI
T2 - Frontiers in neuroscience
J2 - Front Neurosci
PY - 2026
DA - 2026/
VL - 20
SP - 1870124
SN - 1662-4548
PB - Frontiers Media SA
DO - 10.3389/
UR - https://
LA - en
ER -
CSL-JSON
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