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Circuit dynamics of binocular conflict in mouse primary visual cortex.

Code ↔ Paper

8 matches between paragraphs of the paper and lines of its authors' code, computed by the harvester (lexical-v1). Click a colored paragraph or line to see its counterpart.

The 8 matches · 4 of them tie a paragraph to a whole file, not to given lines: weak matches, whose lines are not tinted
  1. [1] § Results › Both regular-spiking and fast-spiking units show prolonged activity with orthogonal stimuli ↔ Units analysis (Fig 2-5)/Group Files and Code/group_analysis.m, lines 106–120 · score 0.78 · 40–80 ms, 100–200 ms, early peak, 40 ms, RS, PV
  2. [2] § Materials and methods › Method details › Electrophysiology recordings and analysis ↔ VEP analysis (Fig 1)/+process/grab_ramp_data.m, lines 1–100 · score 0.77 · notch filter, notch frequencies, detrended, locdetrend, IIR, bandwidth
  3. [3] § Materials and methods › Method details › Single unit activity analysis ↔ Units analysis (Fig 2-5)/Group Files and Code/group_analysis.m, lines 106–120 · score 0.77 · 40–80 ms, 100–200 ms, 40 ms, SUA, RS, peak
  4. [4] § Results › Both regular-spiking and fast-spiking units show prolonged activity with orthogonal stimuli ↔ Units analysis (Fig 2-5)/Group Files and Code/+process/get_spike_widths.m, the whole file · a weak match · score 0.67 · fast spiking, regular spiking, classified, trough, onset, 40 ms
  5. [5] § Materials and methods › Method details › Single unit activity analysis ↔ Units analysis (Fig 2-5)/Individual Files and Code/run_animal.m, lines 128–171 · score 0.67 · high pass filter, clusters, Kilosort, binning, trough, PSTHs
  6. [6] § Results › Both regular-spiking and fast-spiking units show prolonged activity with orthogonal stimuli ↔ Units analysis (Fig 2-5)/Group Files and Code/+process/get_spike_widths.m, the whole file · a weak match · score 0.62 · fast spiking, regular spiking, width, classified, trough, 40 ms
  7. [7] § Results › Both regular-spiking and fast-spiking units show prolonged activity with orthogonal stimuli ↔ Units analysis (Fig 2-5)/Group Files and Code/+view/plot_all_SUA.m, the whole file · a weak match · score 0.59 · firing rates, 80 ms, location, 40 ms, L6, L5
  8. [8] § Results › Both regular-spiking and fast-spiking units show prolonged activity with orthogonal stimuli ↔ Units analysis (Fig 2-5)/Group Files and Code/+view/plot_all_SUA.m, the whole file · a weak match · score 0.54 · Firing rates, 80 ms, 40 ms, L6, L5, SEM

Paper

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The authors' code

MATLAB · 125 lines · 2.8 KB · MIT · 2 matches

  1. %% Load data
  2. mice = [{'DM988'}, {'DM990'}, {'DM991'}, {'DM992'}, {'DM993'}, {'DM994'}, {'DM1005'}, {'DM1006'}, {'DM1007'}, {'DM1009'}, {'DM1010'}];
  3. data_path = '\\bearlab-s2.mit.edu\bearshare\Daniel#\Experiments#\Units\Suppression\Individual Files and Code\';
  4. layer_borders = [300, 60, -80, -260, -460];
  5. group_struct = import.load_mouse_data(mice, data_path);
  6. SUA_struct = import.load_SUA_data(mice, data_path);
  7. %% Organize data
  8. [VEP, VEP_stats, depth_VEPs] = process.VEP_analysis(group_struct);
  9. [CSD, MUA] = process.CSD_MUA_analysis(group_struct);
  10. zMUA = process.zscore_MUA(MUA);
  11. %% Plot VEPs, CSDs, and MUA
  12. view.view_VEPs(VEP, VEP_stats);
  13. view.view_VEPs_by_layer(depth_VEPs)
  14. view.view_group_heatmap(CSD, "CSD", layer_borders)
  15. view.view_group_heatmap(MUA, "MUA", layer_borders)
  16. view.view_group_heatmap(zMUA, "zMUA", layer_borders)
  17. MUA_time = 1:25;
  18. view.view_MUA_by_depth(MUA, layer_borders, MUA_time)
  19. %% Compare with monocular condition
  20. CI = 99; % percent confidence interval
  21. view.view_group_heatmap_compare(CSD, "CSD", layer_borders, CI);
  22. view.view_group_heatmap_compare(MUA, "MUA", layer_borders, CI);
  23. view.view_group_heatmap_compare(zMUA, "zMUA", layer_borders, CI);
  24. %% Plot traces for CSDs and MUA
  25. cortex_borders = [300, -460];
  26. x = view.view_group_traces(zMUA, "MUA", cortex_borders);
  27. cortex_borders = [300, -460];
  28. x = view.view_group_traces(MUA, "MUA", cortex_borders);
  29. %% Organize SUA data
  30. good_cells_only = false;
  31. [SUA, SUA_raster, unit_depths] = process.SUA_analysis(SUA_struct, layer_borders, good_cells_only);
  32. %% Plot SUA
  33. zscore = true;
  34. smooth_data = true;
  35. plot_errorbars = false;
  36. view.plot_layer_SUA(SUA, zscore, smooth_data, plot_errorbars)
  37. view.plot_all_SUA(SUA, zscore, smooth_data, plot_errorbars)
  38. %% Plot single unit PSTHs
  39. zscore = true;
  40. smooth_data = true;
  41. view.plot_SUA_PSTH_by_layer(SUA, zscore, smooth_data)
  42. %% Get rasters for SUA
  43. view.plot_SUA_raster(SUA_raster.pyr.L23, [])
  44. view.plot_SUA_raster(SUA_raster.pyr.L4, [])
  45. view.plot_SUA_raster(SUA_raster.pyr.L5, [])
  46. view.plot_SUA_raster(SUA_raster.pyr.L6, [])
  47. view.plot_SUA_raster(SUA_raster.pv.L23, [])
  48. view.plot_SUA_raster(SUA_raster.pv.L4, [])
  49. view.plot_SUA_raster(SUA_raster.pv.L5, [])
  50. view.plot_SUA_raster(SUA_raster.pv.L6, [])
  51. %% Get SUA to run stats
  52. % Get SUA for each layer for the early peak (40-80 ms) and late peak (100-200 ms)
  53. output_format = 1; % 1 or 2
  54. zscore = false;
  55. SUA_stats = process.get_SUA_stats(SUA, output_format, zscore)
  56. view.plot_SUA_cdf(SUA_stats.pyr.all.early_peak, 'RS early peak');
  57. view.plot_SUA_cdf(SUA_stats.pyr.all.late_peak, 'RS late peak');
  58. view.plot_SUA_cdf(SUA_stats.pv.all.early_peak, 'FS early peak');
  59. view.plot_SUA_cdf(SUA_stats.pv.all.late_peak, 'FS late peak');

group_analysis.m at commit 17469a5, under MIT · at the source

Overview

Authors: Daniel P. Montgomery1,2,3, Daniel A. Bowen2,4, Jin Wu5, Mark F. Bear2, Eric D. Gaier2,4,6
  1. Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, United States
  2. Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, United States
  3. Center for Neuroscience Research, Children’s National Hospital, Washington, DC, United States
  4. Department of Ophthalmology, Boston Children’s Hospital, Boston, MA, United States
  5. Brandeis Neuroscience Graduate Program, Brandeis University, Waltham, MA, United States
  6. Harvard Medical School, Boston, MA, United States
Institutions: Children's National (United States); Massachusetts Institute of Technology (United States); Boston Children's Hospital (United States); Brandeis University (United States); Harvard University (United States)
Journal: Frontiers in systems neuroscience, volume 20, article 1786396
Dates: received 12 January 2026; accepted 29 April 2026; published online 29 May 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.3389/fnsys.2026.1786396 · PMID 42292979 · PMCID PMC13260517 · OpenAlex W7162793557
Open access: gold, a free copy (OpenAlex)
Status: code verified
Categories: EEG (modality), optical imaging (calcium, voltage, 2-photon) (modality), mouse (organism), systems (subfield)
Methods: Spectral & time-frequency, Preprocessing, Statistics, Smoothing, state filtering, decompositions, Evoked potentials, Connectivity, fMRI & imaging, Single-unit activity, calcium imaging
Keywords: binocular rivalry, binocular vision, interocular suppression, primary visual cortex, somatostatin interneurons
Topic: Visual perception and processing mechanisms (Cognitive Neuroscience, Neuroscience), according to OpenAlex
Citations: cited by 1 paper (Europe PMC); 52 references in the paper
Research resources: Cre mice RRID:IMSR_JAX:005628, SOM-Cre mice RRID:IMSR_JAX:018973, CaMK2a-tTA mice RRID:IMSR_JAX:024108, RRID:SCR_002798

Abstract

Binocular vision requires that the brain integrate input from both eyes to form a unified percept. Small interocular differences support depth perception (stereopsis), while larger disparities can cause diplopia or binocular rivalry. The neural mechanisms by which early visual circuits process concordant versus conflicting binocular signals remain incompletely understood. Here, we used visually evoked potentials (VEPs), unit recordings, and 2-photon calcium imaging in the binocular region of mouse primary visual cortex (bV1) to examine how distinct forms of binocular disparity engage local circuits. We found that interocular phase disparities reduced VEP magnitude through decreased neuronal firing early in the response (40–80 ms after stimulus onset). Orientation disparities also decreased VEP magnitude, but via increased firing later in the response (100–200 ms). This late activity was enhanced in both regular-spiking (putative excitatory) and fast-spiking (putative parvalbumin-positive inhibitory) units. In contrast, calcium imaging revealed that somatostatin-positive interneurons were suppressed during orientation conflict. These findings suggest that phase differences suppress bV1 responses via feedforward mechanisms, while orientation disparities prolong activity through a process associated with suppression of somatostatin-positive interneurons. Our results reveal cell-type specific circuit mechanisms engaged by different forms of binocular conflict and provide a foundation for mechanistic investigations of perceptual suppression and rivalry.

Reproduced under the paper's license (CC BY), from the paper cited above.

Repository

Its files are read in the Code ↔ Paper reader above, with 8 matches between paragraphs and lines of code.

danielmontgomery7/suppression-analysis-code

License: MIT
State: the link answers, verified on 28 September 2026
Evidence: files inventoried
Commit: 17469a5f0ab2ddefa01548e606abea6432be1f27, 6 February 2025
Languages: MATLAB (125)
Size: 139 files, 125 scripts
Software Heritage: not archived
Found in: the end of the paper
Holds: README, license file
Not found: CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 28 September 2026: the link answers
  • 28 September 2026: the link answers
127 files

The paper's code and data availability statement is in the Data section.

Tracing map

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  • 1 repository of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
  • 125 scripts, each with its path and the digest of its content;
  • 8 matches between paragraphs of the paper and lines of the code (method lexical-v1);
  • neither the text of the paper nor the code itself.

Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

No dataset and no data link were found in the paper.

Data availability statement

The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.

Reproduced under the paper's license (CC BY), from the paper cited above.

Data and code availability

The code used to analyze visually evoked potentials are available on Github.2 The datasets generated during this study have not been deposited in a public repository but are available from the corresponding author on request.

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

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Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, pages, dates, 5 authors, 5 keywords, 52 references, 4 RRIDs.

Cite

This paper

Montgomery, D. P., Bowen, D. A., Wu, J., Bear, M. F., & Gaier, E. D. (2026). Circuit dynamics of binocular conflict in mouse primary visual cortex. Frontiers in systems neuroscience, 20, 1786396. https://doi.org/10.3389/fnsys.2026.1786396

BibTeX

@article{montgomery2026circuit,
author = {Montgomery, Daniel P. and Bowen, Daniel A. and Wu, Jin and Bear, Mark F. and Gaier, Eric D.},
title = {{Circuit dynamics of binocular conflict in mouse primary visual cortex}},
journal = {Frontiers in systems neuroscience},
year = {2026},
month = may,
volume = {20},
pages = {1786396},
publisher = {Frontiers Media SA},
issn = {1662-5137},
doi = {10.3389/fnsys.2026.1786396},
url = {https://doi.org/10.3389/fnsys.2026.1786396},
pmid = {42292979},
pmcid = {PMC13260517}
}

RIS

TY - JOUR
AU - Montgomery, Daniel P.
AU - Bowen, Daniel A.
AU - Wu, Jin
AU - Bear, Mark F.
AU - Gaier, Eric D.
TI - Circuit dynamics of binocular conflict in mouse primary visual cortex
T2 - Frontiers in systems neuroscience
J2 - Front Syst Neurosci
PY - 2026
DA - 2026/05/29
VL - 20
SP - 1786396
SN - 1662-5137
PB - Frontiers Media SA
DO - 10.3389/fnsys.2026.1786396
UR - https://doi.org/10.3389/fnsys.2026.1786396
LA - en
ER -

CSL-JSON

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