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Continuous flash suppression responses in mouse visual cortex: Stimulus laterality and anesthesia effects.

Overview

Authors: Mathis Bassler1, Lilian Emming1, Christopher J. Whyte2,3, Gerjan Huis In ’t Veld1, Mototaka Suzuki1,4,5, Cyriel M.A. Pennartz1
ORCID iDs: Mathis Bassler, Cyriel M.A. Pennartz
  1. Department of Cognitive and Systems Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, the Netherlands
  2. Centre for Complex Systems, University of Sydney, Sydney, NSW, Australia
  3. Neuroscience Research Theme, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia
  4. Brain Engineering Laboratory, Graduate School of Frontier Biosciences, The University of Osaka, Suita, Japan
  5. Center for Information and Neural Networks, Suita, Japan
Institutions: University of Amsterdam (Netherlands); The University of Sydney (Australia); The University of Osaka (Japan)
Journal: iScience, volume 29, issue 7, article 116628
Dates: received 27 January 2026; accepted 15 June 2026; published online 7 July 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.1016/j.isci.2026.116628 · PMID 42438823 · PMCID PMC13356775 · OpenAlex W4415977413
Open access: gold, a free copy (OpenAlex)
Preprint: doi:10.1101/2025.11.05.686768
Status: code on request
Categories: mouse (organism), systems (subfield)
Methods: Connectivity, Statistics, Machine learning, fMRI & imaging, Single-unit activity, calcium imaging, Physiology & signal measures
Keywords: mouse visual cortex, binocular rivalry, continuous flash suppression, binocular suppression
Topic: Visual perception and processing mechanisms (Cognitive Neuroscience, Neuroscience), according to OpenAlex
Funding: European Union’s Horizon 2020 (945539)
Citations: not cited yet (Europe PMC); 77 references in the paper

Abstract

We investigated whether binocularly conflicting stimuli may induce binocular response suppression in the mouse visual cortex. We presented stimuli adapted from the paradigm of continuous flash suppression to awake and anesthetized mice and examined neuronal responses in visual areas V1 and LM. Neuronal responses to monocular gratings on one eye could be modulated by presenting a conflicting flashing Mondrian stimulus to the other eye. The direction of this modulation depended on the laterality of the preferred grating. Responses of cells with a preference for ipsilateral gratings were strongly suppressed. Similar modulations also occurred under anesthesia, but response recovery after intermittent binocular conflict only occurred in awake mice. Responses to Mondrians were similarly modulated as those to gratings, which suggests that mouse binocular conflict processing exhibits a distinctive dependency on stimulus laterality. A canonical binocular rivalry model could be fitted to our data but failed to exhibit oscillatory activity under binocular conflict.

Reproduced under the paper's license (CC BY), from the paper cited above.

Code

The paper says that its authors' code is available on request: it was not published with the paper, so there is nothing to verify.

The paper's code and data availability statement is in the Data section.

Tracing map

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Data

No dataset and no data link were found in the paper.

Data and code availability

• Data: The data in this article will be shared by the lead contact upon request. • Code: This article does not report original code. • Other: Any additional information required to reanalyze the data reported in this paper is available from the lead contact upon request.

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 6 authors, 4 keywords, 1 funder, 74 references.

Cite

This paper

Bassler, M., Emming, L., Whyte, C. J., In ’t Veld, G. H., Suzuki, M., & Pennartz, C. M. (2026). Continuous flash suppression responses in mouse visual cortex: Stimulus laterality and anesthesia effects. iScience, 29(7), 116628. https://doi.org/10.1016/j.isci.2026.116628

BibTeX

@article{bassler2026continuous,
author = {Bassler, Mathis and Emming, Lilian and Whyte, Christopher J. and In ’t Veld, Gerjan Huis and Suzuki, Mototaka and Pennartz, Cyriel M.A.},
title = {{Continuous flash suppression responses in mouse visual cortex: Stimulus laterality and anesthesia effects}},
journal = {iScience},
year = {2026},
month = jul,
volume = {29},
number = {7},
pages = {116628},
publisher = {Elsevier},
issn = {2589-0042},
doi = {10.1016/j.isci.2026.116628},
url = {https://doi.org/10.1016/j.isci.2026.116628},
pmid = {42438823},
pmcid = {PMC13356775}
}

RIS

TY - JOUR
AU - Bassler, Mathis
AU - Emming, Lilian
AU - Whyte, Christopher J.
AU - In ’t Veld, Gerjan Huis
AU - Suzuki, Mototaka
AU - Pennartz, Cyriel M.A.
TI - Continuous flash suppression responses in mouse visual cortex: Stimulus laterality and anesthesia effects
T2 - iScience
J2 - iScience
PY - 2026
DA - 2026/07/07
VL - 29
IS - 7
SP - 116628
SN - 2589-0042
PB - Elsevier
DO - 10.1016/j.isci.2026.116628
UR - https://doi.org/10.1016/j.isci.2026.116628
LA - en
ER -

CSL-JSON

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