EMILIN-1 in the tumor microenvironment: insights from CNS tumors and beyond.
Overview
- Research Center for Translational Medicine, Sirius University of Science and Technology, Sochi, Russia
- The University of Texas Health Science Center, Houston, TX, United States
Abstract
Elastin Microfibril Interface Located Protein 1 (EMILIN-1) is a multifunctional extracellular glycoprotein, primarily involved in maintaining tissue homeostasis. Known for regulation of elastogenesis and vascular stability, EMILIN-1 has emerged as a key modulator of multiple biological processes, including cell adhesion, migration, and proliferation. Recent experimental data highlight the importance of EMILIN-1 in cancer biology, especially in malignant tumors of the nervous system, where EMILIN-1’s regulatory functions influence tumor progression and metastatic potential. Specifically, EMILIN-1 can exert tumor-suppressive effects by modulating cell signaling pathways of tumor cells and EMILIN-1 can also alter the immune response and promote progression of brain tumors. This review article provides a comprehensive analysis of the recently discovered mechanisms through which EMILIN-1 promotes tumor progression in the nervous system and other sites.
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
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Data
Datasets cited
- portal.brain-map.org/
atlases-and-data/ , at Allen Brain Map; found in the text, “Neural tissue”rnaseq
Versions
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Version 2, 28 September 2026
- Funding: added National Institutes of Health
Version 1, 28 September 2026: the first record
Recorded: type, language, journal, volume, pages, dates, 3 authors, 8 keywords, 73 references.
Cite
This paper
Arsentiev, K. A., Fajardo, A., & Yuzhalin, A. E. (2026). EMILIN-1 in the tumor microenvironment: insights from CNS tumors and beyond. Frontiers in oncology, 16, 1771697. https://
BibTeX
@article{arsentiev2026em
author = {Arsentiev, Kirill A. and Fajardo, Abigail and Yuzhalin, Arseniy E.},
title = {{EMILIN-1 in the tumor microenvironment: insights from CNS tumors and beyond}},
journal = {Frontiers in oncology},
year = {2026},
month = apr,
volume = {16},
pages = {1771697},
publisher = {Frontiers Media SA},
issn = {2234-943X},
doi = {10.3389/
url = {https://
pmid = {41994657},
pmcid = {PMC13078994}
}
RIS
TY - JOUR
AU - Arsentiev, Kirill A.
AU - Fajardo, Abigail
AU - Yuzhalin, Arseniy E.
TI - EMILIN-1 in the tumor microenvironment: insights from CNS tumors and beyond
T2 - Frontiers in oncology
J2 - Front Oncol
PY - 2026
DA - 2026/
VL - 16
SP - 1771697
SN - 2234-943X
PB - Frontiers Media SA
DO - 10.3389/
UR - https://
LA - en
ER -
CSL-JSON
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"DOI": "10.3389/
"PMID": "41994657",
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"URL": "https://
"language": "en",
"issued": {
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}
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