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Ensemble fuzzy multilayer neural perceptron with optimized feature selection for cardiac disease prediction using MRI and ECG data.

Overview

Authors: J K Kiruthika1, P Thangaraj2
  1. Department of Computer Science and Engineering, KPR Institute of Engineering and Technology, Coimbatore, Tamil Nadu, India
  2. Kangeyam Institute of Technology, Kangeyam, Tamil Nadu, India
Journal: Frontiers in physiology, volume 17, article 1719922
Dates: received 27 October 2025; accepted 20 February 2026; published online 22 April 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.3389/fphys.2026.1719922 · PMID 42099916 · PMCID PMC13143658 · OpenAlex W7155182257
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: structural MRI / diffusion (modality), other (modality), methods / tools (subfield)
Methods: Statistics, Machine learning, fMRI & imaging, Connectivity
Keywords: cardiac disease prediction, ensemble-based fuzzy neural network, MRI image analysis, median box filter, multilayer neural perceptron, grey segmentation, feature selection, optimal feature weighting
Topic: ECG Monitoring and Analysis (Cardiology and Cardiovascular Medicine, Medicine), according to OpenAlex
Citations: not cited yet (Europe PMC); 37 references in the paper

Abstract

One of the major causes of death in the general population is cardiovascular disease. Life-threatening cardiac disease is influenced by several factors, including age, gender, blood sugar, cholesterol, heart rate, and more. There are so many factors that it can be challenging for specialists to assess each one. The current approach utilizes electrocardiogram (ECG) data and magnetic resonance imaging (MRI) image features but suffers from poor performance and high error rates. To address this problem, we employ an ensemble-based fuzzy multilayer neural perceptron (EFMLNP) model to predict cardiac disease. Initially, an image from the University of California, Irvine (UCI) Machine Learning Repository was selected to analyze the prognosis of cardiovascular disease. To effectively replicate the raw data values in the dataset, a median box filter (MBF) is used to pre-process the MRI dataset, reducing irrelevant values. The second stage, segmentation, uses adaptive mean gray segmentation (AMGS) to initialize two clusters for regions of interest and non-interest. The dataset is then tested using a feature-selection method based on recursive spectral spider optimization (RSSO) to identify the most pertinent characteristics for diagnosing heart disease (optimal reduced-feature splitting). Lastly, we examine a machine learning feature-extraction model and perform test analysis on the reduced features. The proposed EFMLNP method is evaluated using metrics including precision, recall, and receiver operating characteristic (ROC). The experimental outcome demonstrates that the accuracy is 98.3%, the precision is 97.15%, the recall is 98.43%, the F1-score is 96.34%, and the ROC is 0.96.

Reproduced under the paper's license (CC BY), from the paper cited above.

Code

The paper links to its data, not to its authors' code: see the Data section.

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Data

Datasets cited

Data availability statement

The original contributions presented in the study are included in the article/supplementary material; further inquiries can be directed to the corresponding author.

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 29 September 2026: the first record

Recorded: type, language, journal, volume, pages, dates, 2 authors, 8 keywords, 31 references.

Cite

This paper

Kiruthika, J. K., & Thangaraj, P. (2026). Ensemble fuzzy multilayer neural perceptron with optimized feature selection for cardiac disease prediction using MRI and ECG data. Frontiers in physiology, 17, 1719922. https://doi.org/10.3389/fphys.2026.1719922

BibTeX

@article{kiruthika2026ensemble,
author = {Kiruthika, J K and Thangaraj, P},
title = {{Ensemble fuzzy multilayer neural perceptron with optimized feature selection for cardiac disease prediction using MRI and ECG data}},
journal = {Frontiers in physiology},
year = {2026},
month = apr,
volume = {17},
pages = {1719922},
publisher = {Frontiers Media SA},
issn = {1664-042X},
doi = {10.3389/fphys.2026.1719922},
url = {https://doi.org/10.3389/fphys.2026.1719922},
pmid = {42099916},
pmcid = {PMC13143658}
}

RIS

TY - JOUR
AU - Kiruthika, J K
AU - Thangaraj, P
TI - Ensemble fuzzy multilayer neural perceptron with optimized feature selection for cardiac disease prediction using MRI and ECG data
T2 - Frontiers in physiology
J2 - Front Physiol
PY - 2026
DA - 2026/04/22
VL - 17
SP - 1719922
SN - 1664-042X
PB - Frontiers Media SA
DO - 10.3389/fphys.2026.1719922
UR - https://doi.org/10.3389/fphys.2026.1719922
LA - en
ER -

CSL-JSON

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"volume": "17",
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"DOI": "10.3389/fphys.2026.1719922",
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