CSDE1 Associates with TOM20 and Mitochondrial Protein-Encoding mRNAs in Sensory Neurons.

Overview

1. Department of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 42988, Republic of Korea; (H.J.); (E.J.); (E.P.)
2. Biopharmaceutical Mass Spectrometry Research Unit, Korea Basic Science Institute (KBSI), Ochang 28119, Republic of Korea; (J.Y.L.); (J.H.S.)
3. Department of Bio-Analytical Science, University of Science and Technology (UST), Daejeon 34113, Republic of Korea
4. Department of Biotechnology, Graduate School, Korea University, Seoul 02841, Republic of Korea

Abstract

Mitochondrial proteostasis in neurons relies on the coordinated expression, targeting, and import of a predominantly nuclear-encoded proteome to meet high metabolic demands. Here, we identify the RNA-binding protein cold shock domain containing E1 (CSDE1) as a TOM20-associated factor linked to mitochondrial protein-encoding mRNAs in sensory neurons. CSDE1 immunoprecipitation followed by sequencing from naïve dorsal root ganglion tissue revealed association with nuclear-encoded mitochondrial mRNAs enriched for inner membrane/matrix and oxidative phosphorylation pathways. A subset of CSDE1 localized to mitochondria and associated with the outer mitochondrial membrane import receptor TOM20 via its N-terminal region in an RNA-independent manner. In cultured sensory neurons, CSDE1 depletion reduced the mitochondrial-fraction abundance of representative nuclear-encoded electron transport chain mRNAs and decreased the abundance of selected mitochondrial proteins in the mitochondrial fraction. CSDE1 depletion reduced TMRM-positive mitochondrial puncta density along sensory neurites, without significantly increasing MitoSOX-detectable mitochondrial superoxide signals under either basal or oxidative challenge conditions. These findings identify CSDE1 as a TOM20-associated RNA-binding protein linked to mitochondrial protein-encoding transcripts in sensory neurons and support a model in which CSDE1 contributes to mitochondria-associated post-transcriptional regulation.

Reproduced under the paper's license (CC BY), from the paper cited above.

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Data

Datasets cited

• geo:GSE301321 — at NCBI GEO; found in “Data Availability Statement”

Data Availability Statement

The RNA-sequencing data generated in this study are publicly available in the Gene Expression Omnibus (GEO) database under accession numbers GSE301321 and GSE324285. The RNA-sequencing data generated in this study are publicly available in the Gene Expression Omnibus (GEO) database under accession numbers GSE301321 and GSE324285 (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE301321; https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE324285; accessed on 4 May 2026).

Reproduced under the paper's license (CC BY), from the paper cited above.

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Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 6 authors, 10 keywords, 3 funders, 83 references.

Cite

This paper

Jin, H., Jang, E., Park, E., Lee, J. Y., Song, J. H., & Cho, Y. (2026). CSDE1 Associates with TOM20 and Mitochondrial Protein-Encoding mRNAs in Sensory Neurons. Antioxidants (Basel, Switzerland), 15(5), 608. https://doi.org/10.3390/antiox15050608

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