Regulation of Tau Alternative Splicing: A Novel Role for the Ribonucleoprotein RBM20.
Overview
- Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, 37134 Verona, Italy; (A.C.); (A.V.); (M.G.B.); (G.M.); (F.B.); (M.T.V.); (A.R.); (E.T.)
- Departamento de Biología Molecular, Instituto Universitario de Biología Molecular (IUBM) and Centro de Biología Molecular Severo Ochoa (CBMSO), Universidad Autónoma de Madrid, 28049 Madrid, Spain
Abstract
Tau is a protein associated with microtubules principally expressed in neuronal cells, where it plays a fundamental role in cytoskeleton stabilization and axonal transport. Several diseases collectively named tauopathies, such as Alzheimer’s disease, have been associated with an imbalance in the expression of alternative spliced Tau transcripts and the accumulation of hyperphosphorylated Tau, causing dysfunction and death of neuronal cells. Therefore, understanding the Tau exon splicing mechanisms may contribute to elucidating molecular factors that could underlie the development of neurodegenerative disorders. The aim of this study was to define the role of selected splicing factors in regulating Tau exon expression in cell lines and neuronal organoids. We demonstrated the role of the RNA-binding motif protein 20 (RBM20) splicing factor in regulating Tau exon 6 and exon 10, applying RNA-binding assay and qPCR analyses. Furthermore, we demonstrated that Tau expression was regulated during cerebral organoid differentiation, recapitulating in vivo Tau expression. These results suggest the feasibility of using brain organoid technology to study Tau alternative splicing during neural development, confirming that 3D cellular models could be used to study and characterize pathological processes taking place in Tau-related pathologies.
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data
Datasets cited
- zenodo:19301198, at Zenodo; found in “Data Availability Statement”
Data Availability Statement
The data presented in this study are openly available in Zenodo repository, at doi: 10.5281/
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 1, 30 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 11 authors, 5 keywords, 9 MeSH terms, 3 funders, 81 references.
Cite
This paper
Corsi, A., Valentino, A., Bruno, M. G., Menichetti, G., Belpinati, F., Pereira, M. P., Valenti, M. T., Ruggiero, A., Trabetti, E., Bombieri, C., & Romanelli, M. G. (2026). Regulation of Tau Alternative Splicing: A Novel Role for the Ribonucleoprotein RBM20. International journal of molecular sciences, 27(9), 4001. https://
BibTeX
@article{corsi2026regula
author = {Corsi, Andrea and Valentino, Angela and Bruno, Maria Giusy and Menichetti, Giacomo and Belpinati, Francesca and Pereira, Marta P. and Valenti, Maria Teresa and Ruggiero, Alessandra and Trabetti, Elisabetta and Bombieri, Cristina and Romanelli, Maria Grazia},
title = {{Regulation of Tau Alternative Splicing: A Novel Role for the Ribonucleoprotein RBM20}},
journal = {International journal of molecular sciences},
year = {2026},
month = apr,
volume = {27},
number = {9},
pages = {4001},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
issn = {1422-0067},
doi = {10.3390/
url = {https://
pmid = {42123583},
pmcid = {PMC13164133}
}
RIS
TY - JOUR
AU - Corsi, Andrea
AU - Valentino, Angela
AU - Bruno, Maria Giusy
AU - Menichetti, Giacomo
AU - Belpinati, Francesca
AU - Pereira, Marta P.
AU - Valenti, Maria Teresa
AU - Ruggiero, Alessandra
AU - Trabetti, Elisabetta
AU - Bombieri, Cristina
AU - Romanelli, Maria Grazia
TI - Regulation of Tau Alternative Splicing: A Novel Role for the Ribonucleoprotein RBM20
T2 - International journal of molecular sciences
J2 - Int J Mol Sci
PY - 2026
DA - 2026/
VL - 27
IS - 9
SP - 4001
SN - 1422-0067
PB - Multidisciplinary Digital Publishing Institute (MDPI)
DO - 10.3390/
UR - https://
LA - en
ER -
CSL-JSON
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