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Distribution of Big Tau Isoforms in the Human Central and Peripheral Nervous System.

Overview

Authors: Rama Krishna Koppisetti1,2, Nicolas R Barthélemy1,3, Kanta Horie1,3, Cindy V Ly3, Kaleigh F Roberts4, Srinivas Koutarapu4, Richard J Perrin3,4,5,6, Erin E Franklin4,6, Chiara Pedicone7,8,9, Joshua Orrick7,8, Justin Melendez1,3, Timothy M Miller3,5, Chihiro Sato1,3, Nupur Ghoshal2,3, Alison M Goate7,8,10, Celeste M Karch2,6, Randall J Bateman1,3, Soumya Mukherjee1,3
ORCID iDs: Cindy V Ly, Chiara Pedicone, Timothy M Miller, Chihiro Sato, Nupur Ghoshal, Soumya Mukherjee
  1. The Tracy Family Stable Isotope Labeling Quantitation (SILQ) Center, Washington University School of Medicine, St. Louis, MO, USA
  2. Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA
  3. Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA
  4. Departments of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA
  5. Hope Center for Neurological Disorders, Washington University, St. Louis, MO, USA
  6. Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA
  7. Departments of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA
  8. Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA
  9. Neuroscience sperimentali, IRCCS Azienda Ospedaliera Metropolitana, Policlinico San Martino, Genoa, Italy
  10. Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Institutions: Washington University in St. Louis (United States); Hope Center for Neurological Disorders (United States); Ospedale Policlinico San Martino (Italy); IRCCS Azienda Ospedaliera Metropolitana (Italy); Icahn School of Medicine at Mount Sinai (United States)
Journal: Annals of neurology, volume 100, issue 4, pages 709-736
Dates: received 19 February 2025; accepted 4 June 2026; published online 19 July 2026; in print October 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1002/ana.78300 · PMID 42473039 · PMCID PMC13587115 · OpenAlex W7169729491
Open access: hybrid, a free copy (OpenAlex)
Status: data only
Categories: other (modality), human (organism), other condition (population), Alzheimer's / dementia (population)
Methods: Statistics, Connectivity
MeSH: Brain*, Central Nervous System*, Peripheral Nervous System*, tau Proteins*, Aged, Aged, 80 and over, Alzheimer Disease, Amyotrophic Lateral Sclerosis, Female, Humans, Male, Mass Spectrometry, Middle Aged, Protein Isoforms, Spinal Cord (* major topic)
Topic: Alzheimer's disease research and treatments (Physiology, Medicine), according to OpenAlex
Funding: NINDS NIH HHS (R01NS110890, U54 NS123985, U54NS123985, R01 NS095773, 1U54NS123746-01, RF1 NS110890, R01 NS110890, U54 NS123746, R01NS095773, R56 NS110890); NCATS NIH HHS (UL1 TR004419, UL1TR004419); NIA NIH HHS (P01 AG003991, P01AG026276, P30 AG066444, P01 AG026276, P01AG03991, P30AG066444); NIGMS NIH HHS (P41 GM103422, P41GM103422)
Citations: cited by 2 papers (Europe PMC); 97 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Tracing map

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Data

Datasets cited

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1002/ana.78300.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 2, 28 September 2026

  • Publisher: n/a → Wiley

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 18 authors, 15 MeSH terms, 4 funders, 95 references.

Cite

This paper

Koppisetti, R. K., Barthélemy, N. R., Horie, K., Ly, C. V., Roberts, K. F., Koutarapu, S., Perrin, R. J., Franklin, E. E., Pedicone, C., Orrick, J., Melendez, J., Miller, T. M., Sato, C., Ghoshal, N., Goate, A. M., Karch, C. M., Bateman, R. J., & Mukherjee, S. (2026). Distribution of Big Tau Isoforms in the Human Central and Peripheral Nervous System. Annals of neurology, 100(4), 709-736. https://doi.org/10.1002/ana.78300

BibTeX

@article{koppisetti2026distribution,
author = {Koppisetti, Rama Krishna and Barthélemy, Nicolas R and Horie, Kanta and Ly, Cindy V and Roberts, Kaleigh F and Koutarapu, Srinivas and Perrin, Richard J and Franklin, Erin E and Pedicone, Chiara and Orrick, Joshua and Melendez, Justin and Miller, Timothy M and Sato, Chihiro and Ghoshal, Nupur and Goate, Alison M and Karch, Celeste M and Bateman, Randall J and Mukherjee, Soumya},
title = {{Distribution of Big Tau Isoforms in the Human Central and Peripheral Nervous System}},
journal = {Annals of neurology},
year = {2026},
month = jul,
volume = {100},
number = {4},
pages = {709--736},
publisher = {Wiley},
issn = {0364-5134},
doi = {10.1002/ana.78300},
url = {https://doi.org/10.1002/ana.78300},
pmid = {42473039},
pmcid = {PMC13587115}
}

RIS

TY - JOUR
AU - Koppisetti, Rama Krishna
AU - Barthélemy, Nicolas R
AU - Horie, Kanta
AU - Ly, Cindy V
AU - Roberts, Kaleigh F
AU - Koutarapu, Srinivas
AU - Perrin, Richard J
AU - Franklin, Erin E
AU - Pedicone, Chiara
AU - Orrick, Joshua
AU - Melendez, Justin
AU - Miller, Timothy M
AU - Sato, Chihiro
AU - Ghoshal, Nupur
AU - Goate, Alison M
AU - Karch, Celeste M
AU - Bateman, Randall J
AU - Mukherjee, Soumya
TI - Distribution of Big Tau Isoforms in the Human Central and Peripheral Nervous System
T2 - Annals of neurology
J2 - Ann Neurol
PY - 2026
DA - 2026/07/19
VL - 100
IS - 4
SP - 709
EP - 736
SN - 0364-5134
PB - Wiley
DO - 10.1002/ana.78300
UR - https://doi.org/10.1002/ana.78300
LA - en
ER -

CSL-JSON

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