OSCR

Alterations in the Components of the GABA-Glutamate System During ZIKV Infection: A Neuroscience Approach.

Overview

Authors: Aura Caterine Rengifo1, Julián Naizaque1, Gerardo Santamaría1, Diego Alejandro Alvarez-Díaz2, Andrea Viviana Rodriguez1, Gina Guío-Vega1, Jorge Rivera1, Carlos Eduardo Castro1, Zulma Dueñas3, Orlando Torres-Fernández1
ORCID iDs: Aura Caterine Rengifo, Gina Guío-Vega, Zulma Dueñas, Orlando Torres-Fernández
  1. Grupo de Morfología Celular, Dirección de Investigación en Salud Pública, Instituto Nacional de Salud (INS), Avenue 26 No. 51-20–Zone 6 CAN, Bogotá 111321, Colombia; (J.N.); (G.S.); (A.V.R.); (J.R.); (C.E.C.)
  2. Grupo Investigación y Desarrollo de Vacunas y Biológicos Estratégicos en Salud Pública, Instituto Nacional de Salud (INS), Avenue 26 No. 51-20–Zone 6 CAN, Bogotá 111321, Colombia
  3. Grupo de Neurobiología, Fisiología y Comportamiento, Facultad de Medicina, Universidad Nacional de Colombia, Avenue 30, No. 45-03, Bogotá 111321, Colombia
Institutions: Instituto Nacional de Salud (Colombia); Universidad Nacional de Colombia (Colombia)
Journal: International journal of molecular sciences, volume 27, issue 11, article 4833
Dates: received 16 April 2026; accepted 19 May 2026; published online 27 May 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.3390/ijms27114833 · PMID 42278369 · PMCID PMC13256588 · OpenAlex W7162509269
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: mouse (organism), other condition (population), cellular / molecular (subfield)
Methods: Statistics, Physiology & signal measures
Keywords: NMDA receptors, GABA-A receptors, Zika virus, cerebral cortex, cerebellum, neurotransmitter metabolism and transport
MeSH: gamma-Aminobutyric Acid*, Glutamic Acid*, Zika Virus*, Zika Virus Infection*, Animals, Cerebellum, Cerebral Cortex, Female, Glutamate Decarboxylase, Mice, Mice, Inbred BALB C, Receptors, GABA-A, Receptors, N-Methyl-D-Aspartate (* major topic)
Topic: Mosquito-borne diseases and control (Public Health, Environmental and Occupational Health, Medicine), according to OpenAlex
Funding: Instituto Nacional de Salud (CEMIN Project 11 of 2022); Ministry of Science, Technology and Innovation (210474455818, INS-Colciencias-Salutia Contract No. 672 of 2017)
Citations: cited by 1 paper (Europe PMC); 136 references in the paper

Abstract

Zika virus (ZIKV) infection is associated with severe neurodevelopmental disorders. However, the molecular mechanisms involved in the imbalance of excitatory and inhibitory neurotransmitter systems remain poorly understood. In this study, we evaluated the expression of components of the GABA–glutamate system in neonatal BALB/c mice inoculated with ZIKV at 10 days post-infection (dpi). Analysis of GABA-A and NMDA receptors revealed widespread downregulation of GABA-A and NMDA receptor subunits in the cerebral cortex and cerebellum, except for the alpha-5 and epsilon GABA-A subunits, which were upregulated in the cerebellum. Infected mice also showed increased GABA immunoreactivity and glutamate loss. The enzymes involved in neurotransmitter synthesis or transport confirmed these findings when assessed by qRT-PCR or Western blot, revealing increased expression of GAD-65/67, accompanied by a loss of glutamate dehydrogenase (GLUD) in the cerebral cortex and cerebellum, along with decreased expression of the glutamate transporter (VGLUT) in the cerebral cortex. These findings suggest that GABA synthesis increases during ZIKV infection, creating a neurochemical environment that favors viral replication and contributes to the migration and synaptic defects observed in congenital Zika syndrome.

Reproduced under the paper's license (CC BY), from the paper cited above.

Code

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Data

Datasets cited

Data Availability Statement

https://data.mendeley.com/datasets/2wr5ghgj5c/1 (accessed on 7 January 2026).

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

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Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 10 authors, 6 keywords, 13 MeSH terms, 2 funders, 128 references.

Cite

This paper

Rengifo, A. C., Naizaque, J., Santamaría, G., Alvarez-Díaz, D. A., Rodriguez, A. V., Guío-Vega, G., Rivera, J., Castro, C. E., Dueñas, Z., & Torres-Fernández, O. (2026). Alterations in the Components of the GABA-Glutamate System During ZIKV Infection: A Neuroscience Approach. International journal of molecular sciences, 27(11), 4833. https://doi.org/10.3390/ijms27114833

BibTeX

@article{rengifo2026alterations,
author = {Rengifo, Aura Caterine and Naizaque, Julián and Santamaría, Gerardo and Alvarez-Díaz, Diego Alejandro and Rodriguez, Andrea Viviana and Guío-Vega, Gina and Rivera, Jorge and Castro, Carlos Eduardo and Dueñas, Zulma and Torres-Fernández, Orlando},
title = {{Alterations in the Components of the GABA-Glutamate System During ZIKV Infection: A Neuroscience Approach}},
journal = {International journal of molecular sciences},
year = {2026},
month = may,
volume = {27},
number = {11},
pages = {4833},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
issn = {1422-0067},
doi = {10.3390/ijms27114833},
url = {https://doi.org/10.3390/ijms27114833},
pmid = {42278369},
pmcid = {PMC13256588}
}

RIS

TY - JOUR
AU - Rengifo, Aura Caterine
AU - Naizaque, Julián
AU - Santamaría, Gerardo
AU - Alvarez-Díaz, Diego Alejandro
AU - Rodriguez, Andrea Viviana
AU - Guío-Vega, Gina
AU - Rivera, Jorge
AU - Castro, Carlos Eduardo
AU - Dueñas, Zulma
AU - Torres-Fernández, Orlando
TI - Alterations in the Components of the GABA-Glutamate System During ZIKV Infection: A Neuroscience Approach
T2 - International journal of molecular sciences
J2 - Int J Mol Sci
PY - 2026
DA - 2026/05/27
VL - 27
IS - 11
SP - 4833
SN - 1422-0067
PB - Multidisciplinary Digital Publishing Institute (MDPI)
DO - 10.3390/ijms27114833
UR - https://doi.org/10.3390/ijms27114833
LA - en
ER -

CSL-JSON

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