cART Exacerbates Cocaine-Induced Cortical Neuron Hyperactivity in Non-Transgenic but Not HIV-1 Transgenic Rats.
Overview
Abstract
HIV-associated neurocognitive disorders (HAND) persist despite combination antiretroviral therapy (cART) and can be exacerbated by repeated cocaine (COC) exposure. Because COC, HAND, and cART independently disrupt medial prefrontal cortex (mPFC) function, their combined neurotoxic impact is a critical clinical concern. Using patch-clamp electrophysiology in HIV-1 transgenic (Tg) and non-Tg rats, we examined mPFC pyramidal neuron activity following repeated exposure to COC and/
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
No file of the authors' code could be read here: it is described below, and read at its source.
HulabRush/Coc-HIV-cART-firing-data-
f2acc31a7d87012a90e5d39988dd96c1aee0ec40, 23 May 2025Availability: 1 check, the latest on 30 September 2026: the link answers
- 30 September 2026: the link answers
The paper's code and data availability statement is in the Data section.
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Data
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Data Availability Statement
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Recorded: type, language, journal, volume, issue, pages, dates, 6 authors, 6 keywords, 2 funders, 35 references.
Cite
This paper
Kreko-Pierce, T., Chen, L., Qu, G., Cassoday, S. L., Al-Harthi, L., & Hu, X.-T. (2026). cART Exacerbates Cocaine-Induced Cortical Neuron Hyperactivity in Non-Transgenic but Not HIV-1 Transgenic Rats. Membranes, 16(4), 115. https://
BibTeX
@article{krekopierce2026
author = {Kreko-Pierce, Tabita and Chen, Lihua and Qu, Guojie and Cassoday, Stefanie L and Al-Harthi, Lena and Hu, Xiu-Ti},
title = {{cART Exacerbates Cocaine-Induced Cortical Neuron Hyperactivity in Non-Transgenic but Not HIV-1 Transgenic Rats}},
journal = {Membranes},
year = {2026},
month = mar,
volume = {16},
number = {4},
pages = {115},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
issn = {2077-0375},
doi = {10.3390/
url = {https://
pmid = {42042974},
pmcid = {PMC13117784}
}
RIS
TY - JOUR
AU - Kreko-Pierce, Tabita
AU - Chen, Lihua
AU - Qu, Guojie
AU - Cassoday, Stefanie L
AU - Al-Harthi, Lena
AU - Hu, Xiu-Ti
TI - cART Exacerbates Cocaine-Induced Cortical Neuron Hyperactivity in Non-Transgenic but Not HIV-1 Transgenic Rats
T2 - Membranes
J2 - Membranes (Basel)
PY - 2026
DA - 2026/
VL - 16
IS - 4
SP - 115
SN - 2077-0375
PB - Multidisciplinary Digital Publishing Institute (MDPI)
DO - 10.3390/
UR - https://
LA - en
ER -
CSL-JSON
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