A Corticotectal Pathway Regulates Vibrissal Somatosensory-Mediated Predatory Hunting Learning.
Overview
- The Key Laboratory of Neural and Vascular Biology, Ministry of Education; The Key Laboratory of Vascular Biology of Hebei Province; Department of Neurobiology, Hebei Medical University, Shijiazhuang, China
- National Institute of Biological Sciences; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, China
- Department of Psychological Medicine, Zhongshan Hospital, Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Fudan University, Shanghai, China
Abstract
Although predatory behaviors are evolutionarily conserved, they can be enhanced through experience-dependent plasticity. While vibrissal somatosensation is recognized as a key mediator of hunting behavior, the mechanism underlying vibrissal somatosensory-mediated predatory hunting learning remains not yet well understood. In this study, we report that vibrissal tactile input plays an essential role in hunting learning. Activation of the vGlut1+ S1BF–SC pathway is sufficient to evoke predatory hunting, while its inactivation abolished practice-induced behavioral improvements. SC-projecting vGlut1+ S1BF neurons exhibited robust responses to whisker mechanosensory stimulation. Furthermore, hunting training selectively enhanced α-amino-3-hydroxy-5-meth
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data Availability
All data presented in this research will be made available by the corresponding authors upon request. Any supplementary information necessary for the reanalysis of the data presented in this paper can be obtained from the corresponding authors upon request. The MATLAB code for data analysis can be obtained from the appropriate author upon request.
Reproduced under the paper's license (CC BY), from the paper cited above.
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Version 2, 28 September 2026
- Funding: added National Natural Science Foundation of China: Grant 32171018, China, Grant 32471066, China, Grant H2022206011, China, Grant C2024206032, China; National Major Science and Technology Projects of China: Grant 2021ZD 0203200-04, China]
Version 1, 28 September 2026: the first record
Recorded: type, language, journal, volume, pages, dates, 8 authors, 49 references.
Cite
This paper
Li, Y., Chen, G., Geng, D., Zheng, R., Xie, Z., Zhang, T., Cao, P., & Zhang, F. (2026). A Corticotectal Pathway Regulates Vibrissal Somatosensory-Mediated Predatory Hunting Learning. Research (Washington, D.C.), 9, 1295. https://
BibTeX
@article{li2026corticote
author = {Li, Yaning and Chen, Guoqing and Geng, Dandan and Zheng, Rong and Xie, Zhiyong and Zhang, Tianyun and Cao, Peng and Zhang, Fan},
title = {{A Corticotectal Pathway Regulates Vibrissal Somatosensory-Mediated Predatory Hunting Learning}},
journal = {Research (Washington, D.C.)},
year = {2026},
month = may,
volume = {9},
pages = {1295},
publisher = {American Association for the Advancement of Science},
issn = {2639-5274},
doi = {10.34133/
url = {https://
pmid = {42199849},
pmcid = {PMC13199649}
}
RIS
TY - JOUR
AU - Li, Yaning
AU - Chen, Guoqing
AU - Geng, Dandan
AU - Zheng, Rong
AU - Xie, Zhiyong
AU - Zhang, Tianyun
AU - Cao, Peng
AU - Zhang, Fan
TI - A Corticotectal Pathway Regulates Vibrissal Somatosensory-Mediated Predatory Hunting Learning
T2 - Research (Washington, D.C.)
J2 - Research (Wash D C)
PY - 2026
DA - 2026/
VL - 9
SP - 1295
SN - 2639-5274
PB - American Association for the Advancement of Science
DO - 10.34133/
UR - https://
LA - en
ER -
CSL-JSON
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"author": [
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