Highly attenuated dendritic propagation of isolated synaptic potentials in vivo.
Overview
- Neurotechnology Center, Department of Biological Sciences, Columbia University, New York, NY 10027, USA
- Department of Bioengineering, Stanford University, Stanford, CA 94305, USA
Abstract
The integration of synaptic inputs is a fundamental function of neurons. In the traditional model, excitatory inputs are summed at the soma to generate action potentials. However, how synaptic inputs are integrated by dendrites in vivo remains poorly explored. We used intravital two-photon dendritic imaging with a genetically encoded voltage indicator (accelerated sensor of action potentials 5) together with somatic whole-cell patch clamp recordings to investigate how synaptic depolarizations are transferred to the soma in pyramidal neurons of the mouse somatosensory cortex. We studied the integration of synaptic inputs under spontaneous and sensory-evoked conditions, as well as following electrical and optogenetic stimulation. In all cases, while multiple inputs evoked measurable depolarizations in the cell body, isolated synaptic potentials were strongly attenuated. Our results suggest that isolated synaptic inputs have a minimal contribution to somatic depolarization, whereas coincident inputs within short temporal windows are more effective, indicating a regime of dendritic integration that favors coincident or clustered neuronal activity in cortical networks.
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NTCColumbia
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Recorded: type, language, journal, volume, issue, pages, dates, 7 authors, 11 MeSH terms, 6 funders, 114 references.
Cite
This paper
Cornejo, V. H., Bouazza-Arostegui, B., Alejandre-Garcia, T., Hao, Y., Lee, S., Lin, M. Z., & Yuste, R. (2026). Highly attenuated dendritic propagation of isolated synaptic potentials in vivo. Science advances, 12(33), eadz4123. https://
BibTeX
@article{cornejo2026high
author = {Cornejo, Victor Hugo and Bouazza-Arostegui, Boris and Alejandre-Garcia, Tzitzitlini and Hao, Yukun and Lee, Sungmoo and Lin, Michael Z. and Yuste, Rafael},
title = {{Highly attenuated dendritic propagation of isolated synaptic potentials in vivo}},
journal = {Science advances},
year = {2026},
month = aug,
volume = {12},
number = {33},
pages = {eadz4123},
publisher = {American Association for the Advancement of Science},
issn = {2375-2548},
doi = {10.1126/
url = {https://
pmid = {42600022},
pmcid = {PMC13475487}
}
RIS
TY - JOUR
AU - Cornejo, Victor Hugo
AU - Bouazza-Arostegui, Boris
AU - Alejandre-Garcia, Tzitzitlini
AU - Hao, Yukun
AU - Lee, Sungmoo
AU - Lin, Michael Z.
AU - Yuste, Rafael
TI - Highly attenuated dendritic propagation of isolated synaptic potentials in vivo
T2 - Science advances
J2 - Sci Adv
PY - 2026
DA - 2026/
VL - 12
IS - 33
SP - eadz4123
SN - 2375-2548
PB - American Association for the Advancement of Science
DO - 10.1126/
UR - https://
LA - en
ER -
CSL-JSON
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