A stress-activated neuronal ensemble in the supramammillary nucleus produces anxiety-like behavior in male mice.
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Overview
- Key Laboratory of Modern Teaching Technology, Ministry of Education, Shaanxi Normal University, Xi'an, China
- Department of Histology and Embryology, School of Basic Medical Science, Xi'an Medical University, Xi'an, China
- Laboratory Animal Center, Shaanxi Normal University, Xi’an, China
- School of Psychology, Shaanxi Normal University, Xi'an, China
- Faculty of Education, Shaanxi Normal University, Xi’an, China
Abstract
Anxiety is a prevalent negative emotional state induced by stress; however, the neural mechanism underlying anxiety is still largely unknown. We used acute and chronic stress to induce anxiety and test anxiety-like behavior; immunostaining, multichannel extracellular electrophysiological recording, and Ca2+ imaging to evaluate neuronal activity; and virus-based neuronal tracing to label circuits and manipulate circuitry activity. Here, we identified a hypothalamic region, the supramammillary nucleus (SuM), that plays an important role in anxiety-like behavior. We then characterized a small ensemble of stress-activated neurons (SANs) that are recruited by stress. These SANs respond specifically to stress, and their activation robustly increases anxiety-like behavior in male mice. We also found that ventral subiculum (vSub)-SuM projections, but not dorsal subiculum (dSub)-SuM projections, encode anxiety-like behavior and that inhibition of these vSub-SuM projections has an antianxiety effect. These results indicate that the reactivation of stress-activated supramammillary cells and relevant neural circuits is an important neural process underlying anxiety-like behavior.
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zjm199502/elife2026
bd1432507ec955a590ee50ac216b87aa8ad64bf3, 14 April 2026Availability: 1 check, the latest on 29 September 2026: the link answers
- 29 September 2026: the link answers
The paper's code and data availability statement is in the Data section.
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Version 1, 29 September 2026: the first record
Recorded: type, language, journal, volume, pages, dates, 11 authors, 1 keyword, 10 MeSH terms, 5 funders, 52 references, 5 RRIDs.
Cite
This paper
Zhang, J., Yu, K., Zhang, J., Chang, Y., Sun, X., Qian, Z., Sun, Z., Qiao, Y., Liu, Z., Ren, W., & Han, J. (2026). A stress-activated neuronal ensemble in the supramammillary nucleus produces anxiety-like behavior in male mice. eLife, 14, RP108593. https://
BibTeX
@article{zhang2026stress
author = {Zhang, Jinming and Yu, Kexin and Zhang, Junmin and Chang, Yuan and Sun, Xiao and Qian, Zhaoqiang and Sun, Zongpeng and Qiao, Yanning and Liu, Zhiqiang and Ren, Wei and Han, Jing},
title = {{A stress-activated neuronal ensemble in the supramammillary nucleus produces anxiety-like behavior in male mice}},
journal = {eLife},
year = {2026},
month = apr,
volume = {14},
pages = {RP108593},
publisher = {eLife Sciences Publications, Ltd},
issn = {2050-084X},
doi = {10.7554/
url = {https://
pmid = {41983536},
pmcid = {PMC13082789}
}
RIS
TY - JOUR
AU - Zhang, Jinming
AU - Yu, Kexin
AU - Zhang, Junmin
AU - Chang, Yuan
AU - Sun, Xiao
AU - Qian, Zhaoqiang
AU - Sun, Zongpeng
AU - Qiao, Yanning
AU - Liu, Zhiqiang
AU - Ren, Wei
AU - Han, Jing
TI - A stress-activated neuronal ensemble in the supramammillary nucleus produces anxiety-like behavior in male mice
T2 - eLife
J2 - eLife
PY - 2026
DA - 2026/
VL - 14
SP - RP108593
SN - 2050-084X
PB - eLife Sciences Publications, Ltd
DO - 10.7554/
UR - https://
LA - en
ER -
CSL-JSON
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