OSCR

Illness Severity and Longitudinal Gray Matter Volumes Among People With Major Depressive Disorder.

Overview

Authors: Anna Kraus1, Janik Goltermann1,2,3, Tiana Borgers1, Katharina Dohm1, Dominik Grotegerd1, Elisabeth Schrammen1, Kira Flinkenflügel1, Verena Enneking1, Elisabeth J Leehr1, Joscha Böhnlein1,4, Nils Winter1,5, Alea Bexten1, Tim Hahn1,5, Jochen Bauer6, Marius Gruber1,7,8, Jonathan Repple1,7,8, Katharina Förster9,10, Eva Mennigen11, Nils Opel2,3, Tilo Kircher12, Susanne Meinert1,13, Udo Dannlowski1,14,15,16
ORCID iDs: Jochen Bauer
16 affiliations
  1. Institute for Translational Psychiatry, University of Münster, Münster, Germany
  2. Department of Psychiatry and Neuroscience, Charité–Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
  3. DZPG (German Center for Mental Health), Partner Site Berlin-Potsdam, Berlin, Germany
  4. Clinical Psychology and Translational Psychotherapy, Department of Psychology, University of Münster, Münster, Germany
  5. Institute for Machine Learning in Medicine (focus area psychiatry), University of Münster, Germany
  6. Department of Radiology, University of Münster, Münster, Germany
  7. Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Goethe University, Frankfurt, Germany
  8. Goethe University Frankfurt, Cooperative Brain Imaging Center—CoBIC, Frankfurt, Germany
  9. Child and Adolescent Psychotherapy, Institute of Psychology, University of Hamburg, Hamburg, Germany
  10. Clinical Psychology and Behavioral Neuroscience, Faculty of Psychology, Technische Universität Dresden, Dresden, Germany
  11. Department of Psychiatry, University Hospital Dresden, Dresden, Germany
  12. Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany
  13. Institute for Translational Neuroscience, University of Münster, Münster, Germany
  14. Bielefeld University, Medical School and University Medical Center OWL, Department of Psychiatry, Protestant Hospital of the Bethel Foundation, Bielefeld, Germany
  15. DZPG (German Center for Mental Health), Site Jena Magdeburg Halle, Germany
  16. Center for Intervention and Research on Adaptive and Maladaptive Brain Circuits Underlying Mental Health (C-I-R-C), Site Jena Magdeburg Halle, Germany
Institutions: University of Münster (Germany); Deutsches Zentrum für Psychische Gesundheit (Germany); Charité - Universitätsmedizin Berlin (Germany); Goethe University Frankfurt (Germany); University Hospital Frankfurt (Germany); Universität Hamburg (Germany); Technische Universität Dresden (Germany); University Hospital Carl Gustav Carus (Germany); Philipps University of Marburg (Germany); Bielefeld University (Germany)
Journal: JAMA network open, volume 9, issue 9, article e2633507
Dates: received 27 April 2026; accepted 19 July 2026; published online 14 September 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1001/jamanetworkopen.2026.33507 · PMID 42734915 · PMCID PMC13576425 · OpenAlex W7212737391
Open access: gold, a free copy (OpenAlex)
Status: empty repository
Categories: structural MRI / diffusion (modality), human (organism), depression (population), clinical / translational (subfield)
Methods: Smoothing, state filtering, decompositions, Statistics, fMRI & imaging, Preprocessing
MeSH: Gray Matter*, Major Depressive Disorder*, Adult, Case-Control Studies, Disease Progression, Female, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Severity of Illness Index (* major topic)
Topic: Functional Brain Connectivity Studies (Cognitive Neuroscience, Neuroscience), according to OpenAlex
Citations: not cited yet (Europe PMC); 55 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

No file of the authors' code could be read here: it is described below, and read at its source.

OSF rcfq7

License: none: the authors keep all their rights
State: the link answers, verified on 26 September 2026
Evidence: files inventoried
Size: 7 files, 0 scripts
Software Heritage: not checked
Found in: the references
Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 26 September 2026: the link answers (HTTP 200)
  • 26 September 2026: the link answers (HTTP 200)
At the source: osf.io/rcfq7/overview

Tracing map

Proposed by the machine: these links were found in the paper and verified at the source, without human review. The map will receive a Zenodo DOI once one of the paper's authors has validated it with their ORCID.

What the map holds:

  • 1 repository of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
  • 0 scripts, each with its path and the digest of its content;
  • no match between paragraphs and code yet;
  • neither the text of the paper nor the code itself.

Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

No dataset and no data link were found in the paper.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 3, 28 September 2026

  • Publisher: n/a → American Medical Association

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 22 authors, 12 MeSH terms, 52 references.

Cite

This paper

Kraus, A., Goltermann, J., Borgers, T., Dohm, K., Grotegerd, D., Schrammen, E., Flinkenflügel, K., Enneking, V., Leehr, E. J., Böhnlein, J., Winter, N., Bexten, A., Hahn, T., Bauer, J., Gruber, M., Repple, J., Förster, K., Mennigen, E., Opel, N., . . . Dannlowski, U. (2026). Illness Severity and Longitudinal Gray Matter Volumes Among People With Major Depressive Disorder. JAMA network open, 9(9), e2633507. https://doi.org/10.1001/jamanetworkopen.2026.33507

BibTeX

@article{kraus2026illness,
author = {Kraus, Anna and Goltermann, Janik and Borgers, Tiana and Dohm, Katharina and Grotegerd, Dominik and Schrammen, Elisabeth and Flinkenflügel, Kira and Enneking, Verena and Leehr, Elisabeth J and Böhnlein, Joscha and Winter, Nils and Bexten, Alea and Hahn, Tim and Bauer, Jochen and Gruber, Marius and Repple, Jonathan and Förster, Katharina and Mennigen, Eva and Opel, Nils and Kircher, Tilo and Meinert, Susanne and Dannlowski, Udo},
title = {{Illness Severity and Longitudinal Gray Matter Volumes Among People With Major Depressive Disorder}},
journal = {JAMA network open},
year = {2026},
month = sep,
volume = {9},
number = {9},
pages = {e2633507},
publisher = {American Medical Association},
issn = {2574-3805},
doi = {10.1001/jamanetworkopen.2026.33507},
url = {https://doi.org/10.1001/jamanetworkopen.2026.33507},
pmid = {42734915},
pmcid = {PMC13576425}
}

RIS

TY - JOUR
AU - Kraus, Anna
AU - Goltermann, Janik
AU - Borgers, Tiana
AU - Dohm, Katharina
AU - Grotegerd, Dominik
AU - Schrammen, Elisabeth
AU - Flinkenflügel, Kira
AU - Enneking, Verena
AU - Leehr, Elisabeth J
AU - Böhnlein, Joscha
AU - Winter, Nils
AU - Bexten, Alea
AU - Hahn, Tim
AU - Bauer, Jochen
AU - Gruber, Marius
AU - Repple, Jonathan
AU - Förster, Katharina
AU - Mennigen, Eva
AU - Opel, Nils
AU - Kircher, Tilo
AU - Meinert, Susanne
AU - Dannlowski, Udo
TI - Illness Severity and Longitudinal Gray Matter Volumes Among People With Major Depressive Disorder
T2 - JAMA network open
J2 - JAMA Netw Open
PY - 2026
DA - 2026/09/01
VL - 9
IS - 9
SP - e2633507
SN - 2574-3805
PB - American Medical Association
DO - 10.1001/jamanetworkopen.2026.33507
UR - https://doi.org/10.1001/jamanetworkopen.2026.33507
LA - en
ER -

CSL-JSON

{
"id": "10.1001/jamanetworkopen.2026.33507",
"type": "article-journal",
"title": "Illness Severity and Longitudinal Gray Matter Volumes Among People With Major Depressive Disorder",
"container-title": "JAMA network open",
"author": [
{
"family": "Kraus",
"given": "Anna"
},
{
"family": "Goltermann",
"given": "Janik"
},
{
"family": "Borgers",
"given": "Tiana"
},
{
"family": "Dohm",
"given": "Katharina"
},
{
"family": "Grotegerd",
"given": "Dominik"
},
{
"family": "Schrammen",
"given": "Elisabeth"
},
{
"family": "Flinkenflügel",
"given": "Kira"
},
{
"family": "Enneking",
"given": "Verena"
},
{
"family": "Leehr",
"given": "Elisabeth J"
},
{
"family": "Böhnlein",
"given": "Joscha"
},
{
"family": "Winter",
"given": "Nils"
},
{
"family": "Bexten",
"given": "Alea"
},
{
"family": "Hahn",
"given": "Tim"
},
{
"family": "Bauer",
"given": "Jochen"
},
{
"family": "Gruber",
"given": "Marius"
},
{
"family": "Repple",
"given": "Jonathan"
},
{
"family": "Förster",
"given": "Katharina"
},
{
"family": "Mennigen",
"given": "Eva"
},
{
"family": "Opel",
"given": "Nils"
},
{
"family": "Kircher",
"given": "Tilo"
},
{
"family": "Meinert",
"given": "Susanne"
},
{
"family": "Dannlowski",
"given": "Udo"
}
],
"container-title-short": "JAMA Netw Open",
"volume": "9",
"issue": "9",
"page": "e2633507",
"DOI": "10.1001/jamanetworkopen.2026.33507",
"PMID": "42734915",
"PMCID": "PMC13576425",
"ISSN": "2574-3805",
"publisher": "American Medical Association",
"URL": "https://doi.org/10.1001/jamanetworkopen.2026.33507",
"language": "en",
"issued": {
"date-parts": [
[
2026,
9,
1
]
]
}
}

The tracing map gets a citation of its own once an author has validated it and it has a DOI.

Similar papers

The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.

[1] doi:10.1038/s41398-026-04189-x [code]
Decomposing neuroanatomical heterogeneity in depression: insights from an ENIGMA major depressive disorder working group study in 5146 individuals.
Journal: Translational psychiatry
In common: depression, structural MRI / diffusion, clinical / translational, 3 references, author Jochen Bauer
[2] doi:10.1111/pcn.70066
Acute prefrontal hemodynamic responses to intermittent theta burst stimulation correlate with current depression and episode recurrence: A cross-sectional study.
Journal: Psychiatry and clinical neurosciences
In common: depression, 5 references
[3] doi:10.1038/s44220-026-00680-y [code]
The neuroimaging correlates of depression established across six large-scale population datasets.
Journal: Nature. Mental health
In common: depression, 4 references
[4] doi:10.1093/aje/kwag135 [code]
Depressive symptoms and neuroimaging markers of brain aging in an ethno-racially diverse sample: a Bayesian analysis.
Journal: American journal of epidemiology
In common: depression, structural MRI / diffusion, clinical / translational, 2 references
[5] doi:10.1017/s0033291726104711
Cell-type and spatiotemporal transcriptional signatures of white matter morphometric similarity network alterations in major depressive disorder.
Journal: Psychological medicine
In common: depression, structural MRI / diffusion, 2 references
[6] doi:10.3389/fnbeh.2026.1878769 [code]
<i>ADAMTS18</i> as a candidate gene linking social stress and depression: a cross-species study in African wild dogs (<i>Lycaon pictus</i>) and humans.
Journal: Frontiers in behavioral neuroscience
In common: depression, structural MRI / diffusion, 2 references
[7] doi:10.1016/j.isci.2026.116843
A<sub>3</sub> adenosine receptor regulates depression-like behaviors through astrocyte-nourished excitatory synapse formation.
Journal: iScience
In common: depression, 2 references
[8] doi:10.1192/bjp.2026.10664 [code]
Early effects of a novel 5-HT<sub>4</sub>R agonist (PF-04995274) and the SSRI citalopram on emotional cognition in unmedicated depression: RESTAND study.
Journal: The British journal of psychiatry : the journal of mental science
In common: depression, 2 references
[9] doi:10.1038/s41398-026-04079-2 [code]
Neural Responses to Affective Sentences Reveal Signatures of Depression.
Journal: Translational psychiatry
In common: depression, 2 references
[10] doi:10.1162/imag.a.1152 [code]
Brain patterns linked to neuropsychiatric genetic risk mirror those seen in disease.
Journal: Imaging neuroscience (Cambridge, Mass.)
In common: structural MRI / diffusion, clinical / translational, 2 references

Contribute

The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.

Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.

Request its removal

To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).

Discussion, reproductions, activity

Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.

Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.

Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.