EDNRB-dependent endothelin signaling reduces proliferation and promotes proneural-to-mesenchymal transition in gliomas.
Overview
and 17 other authors
Szimonetta Hideg1, Chantal Ripoll1, Kasandra Aguilar‐Cázarez1, Min Zheng8, Guo‐Hao Huang9, Sheng‐Qing Lv9, Lei Zhang9, Philippe Rondard1, Laurent Prezeau1, Jean‐Philippe Pin1, Hugues Duffau1,10, Luc Bauchet1,10, Valérie Rigau1,11, Franck Denat12, Charles Truillet13, Didier Boquet4, Jean‐Philippe Hugnot1,913 affiliations
- Institut de Génomique Fonctionnelle Université de Montpellier, CNRS, INSERM France
- University of Bordeaux, CNRS, IBGC UMR5095 France
- Université Paris Cité and Université Paris‐Saclay, Inserm, CEA, Stabilité Génétique Cellules Souches et Radiations Fontenay‐aux‐Roses France
- Université Paris‐Saclay, CEA, DMTS, SPI France
- Institut Génétique Humaine Université de Montpellier, CNRS, INSERM France
- 4CS, Laboratory Channels and Connexins in Cancers and Cell Stemness, UR 22751 University of Poitiers France
- PReTI Laboratory, UR 24184 University of Poitiers France
- BioCampus Montpellier Université de Montpellier, CNRS, INSERM France
- Jinfeng Laboratory Chongqing China
- Neurosurgery Department Montpellier University Medical Center France
- Pathology Department Montpellier University Medical Center France
- Université Bourgogne, Europe, CNRS, UMR 6302 Dijon France
- Université Paris‐Saclay, CEA, CNRS, Inserm, BioMaps, Orsay France
Abstract
Diffuse gliomas are primary brain tumors including glioblastomas (GB), astrocytomas, and oligodendrogliomas, the latter two harboring IDH1 mutations and exhibiting slower progression. Gliomas display cellular plasticity, with transitions between astrocyte‐like, oligodendrocyte‐like, progenitor‐like, and mesenchymal‐like states driven by genetic alterations and microenvironmental signals. The proneural‐to‐mesenchymal
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
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Data
Datasets cited
- geo:GSE263796, at NCBI GEO; found in “Data accessibility”
Data accessibility
All raw and processed scRNA‐seq data generated in this study have been deposited in the Gene Expression Omnibus (GEO) under accession number GSE263796 (https://
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 1, 29 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 37 authors, 6 keywords, 10 MeSH terms, 11 funders, 114 references, 2 RRIDs.
Cite
This paper
Pineau, D., Garcia, L., Arnold, H., Hanžek, A., Arrieta, M., Gauthier, L. R., Granotier‐Beckers, C., Boussin, F. D., Herbet, A., Hautière, M., Asei‐Ceschino, V., Jacques, C., Brard, L., Harnois, T., Coronas, V., Constantin, B., Chatelier, A., Chemin, J., Urbach, S., . . . Hugnot, J. (2026). EDNRB-dependent endothelin signaling reduces proliferation and promotes proneural-to-mesenchymal
BibTeX
@article{pineau2026ednrb
author = {Pineau, Donovan and Garcia, Leonor and Arnold, Hugo and Hanžek, Antonija and Arrieta, Maialen and Gauthier, Laurent R and Granotier‐Beckers, Christine and Boussin, François D and Herbet, Amaury and Hautière, Marie and Asei‐Ceschino, Valentin and Jacques, Clémentin and Brard, Laura and Harnois, Thomas and Coronas, Valérie and Constantin, Bruno and Chatelier, Aurélien and Chemin, Jean and Urbach, Serge and Seveno, Martial and Hideg, Szimonetta and Ripoll, Chantal and Aguilar‐Cázarez, Kasandra and Zheng, Min and Huang, Guo‐Hao and Lv, Sheng‐Qing and Zhang, Lei and Rondard, Philippe and Prezeau, Laurent and Pin, Jean‐Philippe and Duffau, Hugues and Bauchet, Luc and Rigau, Valérie and Denat, Franck and Truillet, Charles and Boquet, Didier and Hugnot, Jean‐Philippe},
title = {{EDNRB-dependent endothelin signaling reduces proliferation and promotes proneural-to-mesenchymal
journal = {Molecular oncology},
year = {2026},
month = apr,
volume = {20},
number = {8},
pages = {1933--1962},
publisher = {Wiley},
issn = {1574-7891},
doi = {10.1002/
url = {https://
pmid = {42026941},
pmcid = {PMC13398683}
}
RIS
TY - JOUR
AU - Pineau, Donovan
AU - Garcia, Leonor
AU - Arnold, Hugo
AU - Hanžek, Antonija
AU - Arrieta, Maialen
AU - Gauthier, Laurent R
AU - Granotier‐Beckers, Christine
AU - Boussin, François D
AU - Herbet, Amaury
AU - Hautière, Marie
AU - Asei‐Ceschino, Valentin
AU - Jacques, Clémentin
AU - Brard, Laura
AU - Harnois, Thomas
AU - Coronas, Valérie
AU - Constantin, Bruno
AU - Chatelier, Aurélien
AU - Chemin, Jean
AU - Urbach, Serge
AU - Seveno, Martial
AU - Hideg, Szimonetta
AU - Ripoll, Chantal
AU - Aguilar‐Cázarez, Kasandra
AU - Zheng, Min
AU - Huang, Guo‐Hao
AU - Lv, Sheng‐Qing
AU - Zhang, Lei
AU - Rondard, Philippe
AU - Prezeau, Laurent
AU - Pin, Jean‐Philippe
AU - Duffau, Hugues
AU - Bauchet, Luc
AU - Rigau, Valérie
AU - Denat, Franck
AU - Truillet, Charles
AU - Boquet, Didier
AU - Hugnot, Jean‐Philippe
TI - EDNRB-dependent endothelin signaling reduces proliferation and promotes proneural-to-mesenchymal
T2 - Molecular oncology
J2 - Mol Oncol
PY - 2026
DA - 2026/
VL - 20
IS - 8
SP - 1933
EP - 1962
SN - 1574-7891
PB - Wiley
DO - 10.1002/
UR - https://
LA - en
ER -
CSL-JSON
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