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The Multiple Sclerosis Severity Allele rs10191329<sup>A</sup> and Cognitive Function: A UK Biobank Study.

Overview

Authors: Ioanna Zimianiti1,2, Sheena Waters1, Adil Harroud3,4,5, Pernilla Stridh6, Ruth Dobson1,2, Benjamin M Jacobs1,2
ORCID iDs: Ioanna Zimianiti, Adil Harroud, Pernilla Stridh, Ruth Dobson, Benjamin M Jacobs
  1. Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, UK
  2. Department of Neurology, Royal London Hospital, Barts Health NHS Trust, UK
  3. The Neuro (Montreal Neurological Institute‐Hospital), Montréal, Québec, Canada
  4. Department of Neurology and Neurosurgery, McGill University, Montréal, Québec, Canada
  5. Department of Human Genetics, McGill University, Montréal, Québec, Canada
  6. Department of Clinical Neuroscience, Karolinska Institute, Sweden
Institutions: Queen Mary University of London (United Kingdom); Barts Health NHS Trust (United Kingdom); Royal London Hospital (United Kingdom); Montreal Neurological Institute and Hospital (Canada); McGill University (Canada); Karolinska Institutet (Sweden)
Journal: Annals of clinical and translational neurology, article 10.1002/acn3.70458
Dates: received 22 October 2025; accepted 12 June 2026; published online 22 June 2026; in print June 2026
Type: Brief report · Language: English
License: CC BY
Identifiers: DOI 10.1002/acn3.70458 · PMID 42324924 · PMCID PMC13394037 · OpenAlex W7165547098
Open access: gold, a free copy (OpenAlex)
Status: empty repository
Categories: human (organism), multiple sclerosis (population), cognitive (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions, Machine learning
Keywords: cognitive function, genetics, multiple sclerosis
Topic: Multiple Sclerosis Research Studies (Pathology and Forensic Medicine, Medicine), according to OpenAlex
Citations: not cited yet (Europe PMC); 19 references in the paper

Abstract

The genome‐wide association study of Multiple Sclerosis severity linked the genetic variant rs10191329A to long‐term disability and implicated brain resilience as a determinant of outcome. We hypothesised that rs10191329A might influence cognition in other neurological diseases and healthy controls. We explored the relationship between rs10191329A and cognition using reaction time, fluid intelligence, and prospective memory tests in the UK Biobank. We observed weak but directionally consistent associations between rs10191329A and poorer cognition in controls, with similar but non‐significant trends in Multiple Sclerosis, Parkinson's disease, and dementia. Our results support the hypothesis that rs10191329A might affect multiple sclerosis outcomes by affecting brain health.

Reproduced under the paper's license (CC BY), from the paper cited above.

Code

No file of the authors' code could be read here: it is described below, and read at its source.

izimianiti/UKB-MS-severity-allele-cognition

License: none: the authors keep all their rights
State: the link answers, verified on 27 September 2026
Evidence: files inventoried
Commit: 4b0fae2c2c52e342188d856cfe5db59df24d9c76, 11 April 2026
Size: 1 file, 0 scripts
Software Heritage: not archived
Found in: “Data Availability Statement”
Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 27 September 2026: the link answers
  • 27 September 2026: the link answers
At the source: github.com/izimianiti/UKB-MS-severity-allele-cognition

The paper's code and data availability statement is in the Data section.

Tracing map

Proposed by the machine: these links were found in the paper and verified at the source, without human review. The map will receive a Zenodo DOI once one of the paper's authors has validated it with their ORCID.

What the map holds:

  • 1 repository of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
  • 0 scripts, each with its path and the digest of its content;
  • no match between paragraphs and code yet;
  • neither the text of the paper nor the code itself.

Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

No dataset and no data link were found in the paper.

Data Availability Statement

All code for analysis is provided on: https://github.com/izimianiti/UKB‐MS‐severity‐allele‐cognition (https://github.com/izimianiti/UKB-MS-severity-allele-cognition). UK Biobank data are available on request from https://www.ukbiobank.ac.uk/. This research was conducted under approved application 78,867.

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, pages, dates, 6 authors, 3 keywords, 18 references.

Cite

This paper

Zimianiti, I., Waters, S., Harroud, A., Stridh, P., Dobson, R., & Jacobs, B. M. (2026). The Multiple Sclerosis Severity Allele rs10191329<sup>A</sup> and Cognitive Function: A UK Biobank Study. Annals of clinical and translational neurology, 10.1002/acn3.70458. https://doi.org/10.1002/acn3.70458

BibTeX

@article{zimianiti2026multiple,
author = {Zimianiti, Ioanna and Waters, Sheena and Harroud, Adil and Stridh, Pernilla and Dobson, Ruth and Jacobs, Benjamin M},
title = {{The Multiple Sclerosis Severity Allele rs10191329\<sup\>A\</sup\> and Cognitive Function: A UK Biobank Study}},
journal = {Annals of clinical and translational neurology},
year = {2026},
month = jun,
pages = {10.1002/acn3.70458},
publisher = {Wiley},
issn = {2328-9503},
doi = {10.1002/acn3.70458},
url = {https://doi.org/10.1002/acn3.70458},
pmid = {42324924},
pmcid = {PMC13394037}
}

RIS

TY - JOUR
AU - Zimianiti, Ioanna
AU - Waters, Sheena
AU - Harroud, Adil
AU - Stridh, Pernilla
AU - Dobson, Ruth
AU - Jacobs, Benjamin M
TI - The Multiple Sclerosis Severity Allele rs10191329<sup>A</sup> and Cognitive Function: A UK Biobank Study
T2 - Annals of clinical and translational neurology
J2 - Ann Clin Transl Neurol
PY - 2026
DA - 2026/06/22
SP - 10.1002/acn3.70458
SN - 2328-9503
PB - Wiley
DO - 10.1002/acn3.70458
UR - https://doi.org/10.1002/acn3.70458
LA - en
ER -

CSL-JSON

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The tracing map gets a citation of its own once an author has validated it and it has a DOI.

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