Modulation of miR-23b Wnt/β-catenin Axis Strengthens Endothelial Barrier Properties.
Overview
- Scintillon Aging Research Center, Scintillon Research Institute, San Diego, California, USA
- Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA
- Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, USA
- Department of Biological Sciences, Columbia University Irving Medical Center, New York, New York, USA
- ENDomics Lab, Department of Oncology, Hematology and Bone Marrow Transplantation, University Medical Center Hamburg‐Eppendorf, Hamburg, Germany
Abstract
Blood‐brain barrier (BBB) disruption drives stroke and other CNS disorders pathology, yet restoring its integrity remains challenging. Using an unbiased anti‐miR lentiviral screen, miR‐23b was identified as a critical negative regulator of BBB integrity in brain endothelial cells (BECs). Targeted inhibition of miR‐23b using anti‐miR‐23b, validated by Wnt‐reporter, Wnt‐rescue, and eCLIP analysis, demonstrates that BEC miR‐23b silencing, enhances junctional protein expression and strengthens barrier function while suppressing transcellular transport. Global multi‐omics analysis reveals that miR‐23b acts as a robust driver of angiogenesis‐specific genes and proteins. Conversely, anti‐miR‐23b induces the expression of factors essential for BBB stabilization and repair. Notably, anti‐miR‐23b enhances these protective barrier properties through a multi‐faceted regulation of Wnt/
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
The paper links to its data, not to its authors' code: see the Data section.
Tracing map
A tracing map links a paper to the code its authors published: this paper has none, so it has no map.
Data
Data links
- ncbi.nlm.nih.gov/
sra , NCBI; found in “Data Availability Statement”
Data Availability Statement
All mass spectrometry raw data have been deposited in an international public repository (MassIVE at https://
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 1, 27 September 2026: the first record
Recorded: type, language, journal, pages, dates, 17 authors, 5 keywords, 6 funders, 119 references.
Cite
This paper
Martinez, V. A., Presby, R. E., Nakanishi, S., Gaur, P., Akcan, U., Daugaard Krog, J., Daugaard Krog, I., Das, L., Johnson, D. S., Jamoul, D., Jury, D., Lawson, B., Körbelin, J., Brown, L. M., Menon, V., Agalliu, D., & Munk Pedersen, I. (2026). Modulation of miR-23b Wnt/
BibTeX
@article{martinez2026mod
author = {Martinez, Victor Anthony and Presby, Rose E and Nakanishi, Sara and Gaur, Pallavi and Akcan, Ugur and Daugaard Krog, Johannes and Daugaard Krog, Iben and Das, Lipi and Johnson, David S and Jamoul, Danny and Jury, Douglas and Lawson, Brian and Körbelin, Jacob and Brown, Lewis M and Menon, Vilas and Agalliu, Dritan and Munk Pedersen, Irene},
title = {{Modulation of miR-23b Wnt/
journal = {Advanced science (Weinheim, Baden-Wurttemberg, Germany)},
year = {2026},
month = jul,
pages = {e18421},
publisher = {Wiley},
issn = {2198-3844},
doi = {10.1002/
url = {https://
pmid = {42531597},
pmcid = {PMC13423495}
}
RIS
TY - JOUR
AU - Martinez, Victor Anthony
AU - Presby, Rose E
AU - Nakanishi, Sara
AU - Gaur, Pallavi
AU - Akcan, Ugur
AU - Daugaard Krog, Johannes
AU - Daugaard Krog, Iben
AU - Das, Lipi
AU - Johnson, David S
AU - Jamoul, Danny
AU - Jury, Douglas
AU - Lawson, Brian
AU - Körbelin, Jacob
AU - Brown, Lewis M
AU - Menon, Vilas
AU - Agalliu, Dritan
AU - Munk Pedersen, Irene
TI - Modulation of miR-23b Wnt/
T2 - Advanced science (Weinheim, Baden-Wurttemberg, Germany)
J2 - Adv Sci (Weinh)
PY - 2026
DA - 2026/
SP - e18421
SN - 2198-3844
PB - Wiley
DO - 10.1002/
UR - https://
LA - en
ER -
CSL-JSON
{
"id": "10.1002/
"type": "article-journal",
"title": "Modulation of miR-23b Wnt/
"container-title": "Advanced science (Weinheim, Baden-Wurttemberg, Germany)",
"author": [
{
"family": "Martinez",
"given": "Victor Anthony"
},
{
"family": "Presby",
"given": "Rose E"
},
{
"family": "Nakanishi",
"given": "Sara"
},
{
"family": "Gaur",
"given": "Pallavi"
},
{
"family": "Akcan",
"given": "Ugur"
},
{
"family": "Daugaard Krog",
"given": "Johannes"
},
{
"family": "Daugaard Krog",
"given": "Iben"
},
{
"family": "Das",
"given": "Lipi"
},
{
"family": "Johnson",
"given": "David S"
},
{
"family": "Jamoul",
"given": "Danny"
},
{
"family": "Jury",
"given": "Douglas"
},
{
"family": "Lawson",
"given": "Brian"
},
{
"family": "Körbelin",
"given": "Jacob"
},
{
"family": "Brown",
"given": "Lewis M"
},
{
"family": "Menon",
"given": "Vilas"
},
{
"family": "Agalliu",
"given": "Dritan"
},
{
"family": "Munk Pedersen",
"given": "Irene"
}
],
"container-title-short":
"page": "e18421",
"DOI": "10.1002/
"PMID": "42531597",
"PMCID": "PMC13423495",
"ISSN": "2198-3844",
"publisher": "Wiley",
"URL": "https://
"language": "en",
"issued": {
"date-parts": [
[
2026,
7,
30
]
]
}
}
Similar papers
The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.
- [1] doi:10.26508/lsa.202503431
- miR-133a-3p and miR-338-3p shape neural crest derivatives in zebrafish.Journal: Life science allianceIn common: 5 references
- [2] doi:10.1038/s41419-026-09062-9
- Knockdown of endothelial Serpine1 improves stroke recovery by attenuating peri-infarct blood flow and blood-brain barrier disruption.Journal: Cell death & diseaseIn common: stroke, cellular / molecular, 2 references
- [3] doi:10.1186/s12929-026-01271-w
- Lack of cortistatin drives neuroimmune and vascular dysfunction in brain ischemia.Journal: Journal of biomedical scienceIn common: stroke, cellular / molecular, 2 references
- [4] doi:10.3390/ijms27177542
- Assessment of the Association of Periodontitis and Diabetes Mellitus with Alzheimer's Disease in a Mouse Model.Journal: International journal of molecular sciencesIn common: cellular / molecular, 2 references
- [5] doi:10.1038/s41467-026-73373-w [code]
- Mapping neuro-vascular unit communications reveals distinct angiogenic programs across developing mouse brain regions.Journal: Nature communicationsIn common: 2 references
- [6] doi:10.1172/jci197345
- Catecholamine-mediated release of miR-133a-3p from adipocytes regulates the onset of chronic primary pain.Journal: The Journal of clinical investigationIn common: cellular / molecular, 2 references
- [7] doi:10.1371/journal.pcbi.1014532 [code]
- High reelin expression may explain why a subgroup of entorhinal cortex neurons functions as an initial nucleation site of Alzheimer's disease.Journal: PLoS computational biologyIn common: 2 references
- [8] doi:10.1371/journal.pbio.3003856 [code]
- Aging and metabolism contribute separately to brain-body health.Journal: PLoS biologyIn common: 2 references
- [9] doi:10.1097/md.0000000000050324
- Transcriptomic integration reveals immune heterogeneity in vascular dementia and identifies ELF2 as a candidate therapeutic target.Journal: MedicineIn common: stroke, cellular / molecular, 1 reference
- [10] doi:10.1177/0271678x261468891
- Endothelial estrogen receptor alpha (ESR1) regulates cerebral cavernous malformation pathogenesis via MEKK3-KLF signaling pathway.Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and MetabolismIn common: stroke, cellular / molecular, 1 reference
Contribute
The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.
Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.
Claim this paper
Correct its record
Say what each link of this record is, remove the ones that are not the paper's, add the ones that are missing. The correction becomes a new version of the record, in its Versions section.
Request its removal
To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).
Discussion, reproductions, activity
Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.
Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.
Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.