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CRISPR/Cas9 screen in human iPSC-derived cortical neurons identifies NEK6 as a novel disease modifier of C9orf72 poly(PR) toxicity.

A correction to this paper has been published: the notice, 42222906, from Europe PMC.

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emc2cube/Bioinformatics

License: EUPL-1.2
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Tools found in the code: DESeq2, pheatmap

Overview

Authors: Wenting Guo, Haibo Wang, Arun Kumar Tharkeshwar, Julien Couthouis, Elke Braems, Pegah Masrori, Evelien Van Schoor, Yannan Fan, Karan Ahuja, Matthieu Moisse, Maarten Jacquemyn, Rodrigo Furtado Madeiro da Costa, Madhavsai Gajjar, Sriram Balusu, Tine Tricot, Laura Fumagalli, Nicole Hersmus, Rekin’s Janky, Francis Impens, Pieter Vanden Berghe
and 10 other authorsRitchie Ho, Dietmar Rudolf Thal, Rik Vandenberghe, Muralidhar L Hegde, Siddharthan Chandran, Bart De Strooper, Dirk Daelemans, Philip Van Damme, Ludo Van Den Bosch, Catherine Verfaillie
Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association
Published: 22 August 2022
Type: Research article
Status: code verified (how the code is found and verified)
DOI: 10.1002/alz.12760
License: CC BY
Institutions: VIB-KU Leuven Center for Brain & Disease Research (Belgium), Leuven Stem Cell Institute (Belgium), KU Leuven (Belgium), Weill Cornell Medicine (United States), Houston Methodist Research Institute (United States), Stanford Medicine (United States), Stanford University (United States), Universitair Ziekenhuis Leuven (Belgium), Rega Institute for Medical Research (Belgium), Ghent University (Belgium), VIB-UGent Center for Medical Biotechnology (Belgium), Cedars-Sinai Medical Center (United States), UK Dementia Research Institute (United Kingdom), University College London (United Kingdom), University of Edinburgh (United Kingdom)
Categories: human (organism), zebrafish (organism), other condition (population), Alzheimer's / dementia (population), cellular / molecular (subfield)

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