Neural embedding of frailty in cognitively unimpaired aging and dementia across Latin America.
Overview
and 13 other authors
Maira Okada de Oliveira18,26, Stefanie D. Pina‐Escudero18,25, Katherine L. Possin18,25, Elisa de Paula França Resende18,27, Pablo Reyes28, Hernando Santamaria‐Garcia28,29, Andrea Slachevsky30,31,32,33, Leonel T. Takada26, Paulina Vergara2, Kristine Yaffe18,34, Jennifer S. Yokoyama18,25,35, Roman Romero‐Ortuño2,36, Agustin Ibanez1,2,19,37,3838 affiliations
- Latin American Brain Health Institute (BrainLat) Universidad Adolfo Ibañez Santiago de Chile, Metropolitan Region of Santiago Chile
- Global Brain Health Institute (GBHI) Trinity College Dublin Dublin Ireland
- Grupo de Neurociencias de Antioquia Facultad de Medicina Universidad de Antioquia Medellín Colombia
- Dirección de Enseñanza Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Mexico City Mexico
- Univ. Bordeaux Inserm, Bordeaux Population Health Research Center Bordeaux France
- Centro de Investigación Clínica Avanzada (CICA) – Hospital Clínico Universidad de Chile, Santiago Chile Independencia Santiago Chile
- Departamento de Neurología y Neurocirugía Hospital Clínico Universidad de Chile Independencia Santiago Chile
- Departamento de Neurociencia Facultad de Medicina Universidad de Chile Independencia Santiago Chile
- Departamento de Neurología y Psiquiatría Clínica Alemana de Santiago‐Universidad del Desarrollo Santiago Chile
- Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) Buenos Aires Argentina
- Instituto de Ciencias Biomédicas (ICBM) Facultad de Ciencias Médicas Universidad Católica de Cuyo San Juan Argentina
- Unidad de diagnóstico de deterioro cognitivo y prevención de demencia, Instituto Peruano de Neurociencias Lima Perú
- Unidad de investigación, Equilibria Lima Perú
- Departamento de Neurología y Neurocirugía. Hospital Clínico Universidad de Chile Santiago Chile
- Departamento de Neurociencia Facultad de medicina Universidad de Chile Santiago Chile
- Alzheimer Aguascalientes Family Foundation Aguascalientes Mexico
- Departamento de Lingüística y Literatura Facultad de Humanidades Universidad de Santiago de Chile Santiago Chile
- Global Brain Health Institute University of California San Francisco California USA
- Cognitive Neuroscience Center Universidad de San Andrés Buenos Aires Argentina
- Department of Anesthesia Critical Care and Pain Medicine Massachusetts General Hospital Harvard Medical School Boston Massachusetts USA
- Division of Sleep Medicine Harvard Medical School Boston Massachusetts USA
- The Broad Institute of MIT and Harvard Cambridge Massachusetts USA
- Departamento de Salud Mental Hospital Universitario Fundación Santa Fe Bogotá Colombia
- Centro de Memoria y Cognición Hospital Universitario San Ignacio Bogotá Colombia
- Department of Neurology Memory and Aging Center University of California San Francisco California USA
- Cognitive Neurology and Behavioral Unit (GNCC) University of São Paulo São Paulo Brazil
- Universidade Federal de Minas Gerais Belo Horizonte Minas Gerais Brazil
- Pontificia Universidad Javeriana Bogotá, D.C. Colombia
- Hospital Universitario San Ignacio Center for Memory and Cognition, Intellectus Bogotá, D.C Colombia
- Geroscience Center for Brain Health and Metabolism (GERO) Santiago de Chile, Metropolitan Region of Santiago Chile
- Memory and Neuropsychiatric Center (CMYN) Neurology Department Hospital del Salvador & Faculty of Medicine University of Chile Santiago de Chile Chile
- Neuropsychology and Clinical Neuroscience Laboratory (LANNEC) Physiopathology Program – Institute of Biomedical Sciences Neuroscience and East Neuroscience Departments Faculty of Medicine University of Chile Santiago de Chile Chile
- Departamento de Medicina Servicio de Neurología Clínica Alemana‐Universidad del Desarrollo Santiago de Chile, Metropolitan Region of Santiago Chile
- Department of Psychiatry Weill Institute for Neurosciences University of California San Francisco California USA
- Department of Epidemiology & Biostatistics University of California San Francisco California USA
- Discipline of Medical Gerontology School of Medicine Trinity College Dublin Ireland
- Department of Biophysics School of Medicine Istanbul Medipol University Istanbul Türkiye
- Barcelonaβeta Brain Research Center (BBRC) Pasqual Maragall Foundation Barcelona Spain
Abstract
INTRODUCTION: Frailty influences dementia risk and severity. However, its role in differentiating dementia subtypes and associations with brain structural and functional alterations remain understudied, especially in Latin America.
METHODS: Multi‐Partner Consortium to Expand Dementia Research in Latin America data included 3461 participants (cognitively unimpaired [CU], Alzheimer's disease [AD], and frontotemporal lobar degeneration [FTLD]) from Latin America using a frailty index constructed from 32 health‐related variables. XGBoost‐logistic regression models tested group discrimination, and voxel‐based morphometry plus functional connectivity analyses explored neural correlates.
RESULTS: Frailty distinguished CU from AD (area under the curve [AUC] = 0.85) and CU from FTLD (AUC = 0.88) but not AD from FTLD (AUC = 0.59). Higher frailty was linked to widespread gray matter loss, with temporal involvement in CU and stronger frontotemporal effects in dementia, particularly FTLD. Connectivity analyses showed fronto‐temporo‐posterior
DISCUSSION: Findings position frailty as a promising marker for identifying AD and FTLD relative to CU individuals, linked with brain health alterations in Latin American populations.
Reproduced under the paper's license (CC BY), from the paper cited above.
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Version 1, 28 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 33 authors, 12 keywords, 12 MeSH terms, 24 funders, 116 references.
Cite
This paper
Migeot, J., Wen, O., Gonzalez‐Gomez, R., Hernandez, H., Aguillon, D., Avila‐Funes, J. A., Behrens, M. I., Bruno, M. A., Custodio, N., Delgado, C., Duran‐Aniotz, C., Duron‐Reyes, D., García, A. M., Godoy, M. E., Hu, K., Lawlor, B., Li, P., Maito, M. A., Matallana, D. L., . . . Ibanez, A. (2026). Neural embedding of frailty in cognitively unimpaired aging and dementia across Latin America. Alzheimer's & dementia : the journal of the Alzheimer's Association, 22(4), e71232. https://
BibTeX
@article{migeot2026neura
author = {Migeot, Joaquin and Wen, Olivia and Gonzalez‐Gomez, Raul and Hernandez, Hernan and Aguillon, David and Avila‐Funes, Jose Alberto and Behrens, Maria I. and Bruno, Martin A. and Custodio, Nilton and Delgado, Carolina and Duran‐Aniotz, Claudia and Duron‐Reyes, Dafne and García, Adolfo M. and Godoy, Maria E. and Hu, Kun and Lawlor, Brian and Li, Peng and Maito, Marcelo Adrian and Matallana, Diana L. and Miller, Bruce and de Oliveira, Maira Okada and Pina‐Escudero, Stefanie D. and Possin, Katherine L. and Resende, Elisa de Paula França and Reyes, Pablo and Santamaria‐Garcia, Hernando and Slachevsky, Andrea and Takada, Leonel T. and Vergara, Paulina and Yaffe, Kristine and Yokoyama, Jennifer S. and Romero‐Ortuño, Roman and Ibanez, Agustin},
title = {{Neural embedding of frailty in cognitively unimpaired aging and dementia across Latin America}},
journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
year = {2026},
month = apr,
volume = {22},
number = {4},
pages = {e71232},
publisher = {Wiley},
issn = {1552-5260},
doi = {10.1002/
url = {https://
pmid = {42017463},
pmcid = {PMC13100973}
}
RIS
TY - JOUR
AU - Migeot, Joaquin
AU - Wen, Olivia
AU - Gonzalez‐Gomez, Raul
AU - Hernandez, Hernan
AU - Aguillon, David
AU - Avila‐Funes, Jose Alberto
AU - Behrens, Maria I.
AU - Bruno, Martin A.
AU - Custodio, Nilton
AU - Delgado, Carolina
AU - Duran‐Aniotz, Claudia
AU - Duron‐Reyes, Dafne
AU - García, Adolfo M.
AU - Godoy, Maria E.
AU - Hu, Kun
AU - Lawlor, Brian
AU - Li, Peng
AU - Maito, Marcelo Adrian
AU - Matallana, Diana L.
AU - Miller, Bruce
AU - de Oliveira, Maira Okada
AU - Pina‐Escudero, Stefanie D.
AU - Possin, Katherine L.
AU - Resende, Elisa de Paula França
AU - Reyes, Pablo
AU - Santamaria‐Garcia, Hernando
AU - Slachevsky, Andrea
AU - Takada, Leonel T.
AU - Vergara, Paulina
AU - Yaffe, Kristine
AU - Yokoyama, Jennifer S.
AU - Romero‐Ortuño, Roman
AU - Ibanez, Agustin
TI - Neural embedding of frailty in cognitively unimpaired aging and dementia across Latin America
T2 - Alzheimer's & dementia : the journal of the Alzheimer's Association
J2 - Alzheimers Dement
PY - 2026
DA - 2026/
VL - 22
IS - 4
SP - e71232
SN - 1552-5260
PB - Wiley
DO - 10.1002/
UR - https://
LA - en
ER -
CSL-JSON
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