OSCR

How does type 2 diabetes modify the risk of Alzheimer's disease?

Overview

Authors: G T Sutherland1,2, A Chen1, H‐T Nguyen‐Hao1, H Mundell1,2, E Aladyeva3, M J Hofer4, O Harari3, S M Twigg5,6,7
ORCID iDs: G T Sutherland, E Aladyeva
  1. Sydney Brainomics, School of Medical Sciences and Charles Perkins Centre Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia
  2. New South Wales Brain Tissue Resource Centre, School of Medical Sciences and Charles Perkins Centre, Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia
  3. Department of Neurology and Neurological Research Institute, Ohio State University, Columbus, Ohio, USA
  4. School of Life and Environmental Sciences and Charles Perkins Centre, Faculty of Science, The University of Sydney, Sydney, New South Wales, Australia
  5. Greg Brown Diabetes & Endocrine Research Laboratory, Charles Perkins Centre, Charles Perkins Centre, The University of Sydney, Camperdown, New South Wales, Australia
  6. Sydney Medical School (Central), Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia
  7. Department of Endocrinology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
Institutions: The University of Sydney (Australia); The Ohio State University (United States); Royal Prince Alfred Hospital (Australia)
Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association, volume 22, issue 5, article e71471
Dates: received 28 August 2025; accepted 19 March 2026; published online 18 May 2026; in print May 2026
Type: Review · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1002/alz.71471 · PMID 42151730 · PMCID PMC13183603 · OpenAlex W7161608221
Open access: hybrid, a free copy (OpenAlex)
Status: code verified
Categories: genetics / omics (modality), human (organism), other condition (population), Alzheimer's / dementia (population), cellular / molecular (subfield)
Methods: Statistics, Connectivity, Machine learning
Keywords: Alzheimer's disease, glucose, lipids, microglia, transcriptomics, Type 2 diabetes
MeSH: Alzheimer Disease*, Diabetes Mellitus, Type 2*, Animals, Brain, Humans, Inflammation, Microglia, Risk Factors (* major topic)
Topic: Neuroinflammation and Neurodegeneration Mechanisms (Neurology, Neuroscience), according to OpenAlex
Funding: Lucas Papaw Foundation
Citations: cited by 1 paper (Europe PMC); 196 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

No file of the authors' code could be read here: it is described below, and read at its source.

github.sydney.edu.au/sydney-brainomics/t2d-ad-review

License: none: the authors keep all their rights
State: the link answers, verified on 27 September 2026
Evidence: the link answers
Software Heritage: not checked
Found in: the text, “Validation of bulk tissue RNAseq”
Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 27 September 2026: the link answers (HTTP 200)
  • 27 September 2026: the link answers (HTTP 200)
At the source: github.sydney.edu.au/Sydney-Brainomics/T2D-AD-REVIEW

Tracing map

Proposed by the machine: these links were found in the paper and verified at the source, without human review. The map will receive a Zenodo DOI once one of the paper's authors has validated it with their ORCID.

What the map holds:

  • 1 repository of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
  • 0 scripts, each with its path and the digest of its content;
  • no match between paragraphs and code yet;
  • neither the text of the paper nor the code itself.

Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

No dataset and no data link were found in the paper.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 8 authors, 6 keywords, 8 MeSH terms, 1 funder, 194 references.

Cite

This paper

Sutherland, G. T., Chen, A., Nguyen‐Hao, H., Mundell, H., Aladyeva, E., Hofer, M. J., Harari, O., & Twigg, S. M. (2026). How does type 2 diabetes modify the risk of Alzheimer's disease? Alzheimer's & dementia : the journal of the Alzheimer's Association, 22(5), e71471. https://doi.org/10.1002/alz.71471

BibTeX

@article{sutherland2026how,
author = {Sutherland, G T and Chen, A and Nguyen‐Hao, H‐T and Mundell, H and Aladyeva, E and Hofer, M J and Harari, O and Twigg, S M},
title = {{How does type 2 diabetes modify the risk of Alzheimer's disease?}},
journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
year = {2026},
month = may,
volume = {22},
number = {5},
pages = {e71471},
publisher = {Wiley},
issn = {1552-5260},
doi = {10.1002/alz.71471},
url = {https://doi.org/10.1002/alz.71471},
pmid = {42151730},
pmcid = {PMC13183603}
}

RIS

TY - JOUR
AU - Sutherland, G T
AU - Chen, A
AU - Nguyen‐Hao, H‐T
AU - Mundell, H
AU - Aladyeva, E
AU - Hofer, M J
AU - Harari, O
AU - Twigg, S M
TI - How does type 2 diabetes modify the risk of Alzheimer's disease?
T2 - Alzheimer's & dementia : the journal of the Alzheimer's Association
J2 - Alzheimers Dement
PY - 2026
DA - 2026/05/01
VL - 22
IS - 5
SP - e71471
SN - 1552-5260
PB - Wiley
DO - 10.1002/alz.71471
UR - https://doi.org/10.1002/alz.71471
LA - en
ER -

CSL-JSON

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The tracing map gets a citation of its own once an author has validated it and it has a DOI.

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