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Correlation between in vivo <sup>18</sup>F-flortaucipir PET and whole-brain postmortem histological tau signals in Alzheimer's disease.

Overview

Authors: Yishu Chao1, Yuheng Chen2,3, Trevor A. Chadwick1, Theresa M. Harrison1, Leonardo Iaccarino4, Helmut Heinsen5, Daniela Ushizima6,7, Duygu Tosun8, William J. Jagust1, Lea T. Grinberg2,3,9,10
ORCID iDs: Yuheng Chen, Lea T. Grinberg
  1. Department of Neuroscience University of California, Berkeley Berkeley California USA
  2. Memory and Aging Center, Departments of Neurology and Pathology University of California San Francisco California USA
  3. Department of Neuroscience Mayo Clinic Jacksonville Florida USA
  4. Lilly Corporate Center Eli Lilly and Company Indianapolis Indiana USA
  5. Josef‐Schneider‐Strasse 11 University of Würzburg Würzburg Germany
  6. Applied Mathematics and Computational Research Division Lawrence Berkeley National Laboratory Berkeley California USA
  7. Bakar Computational Health Sciences Institute University of California, San Francisco San Francisco California USA
  8. Department of Radiology and Biomedical Imaging University of California, San Francisco San Francisco California USA
  9. LIM‐22, Department of Pathology University of São Paulo São Paulo São Paulo Brazil
  10. Department of Laboratory Medicine and Pathology Mayo Clinic Jacksonville Florida USA
Institutions: University of California, Berkeley (United States); Mayo Clinic (United States); University of California, San Francisco (United States); Mayo Clinic in Florida (United States); Eli Lilly (United States) (United States); University of Würzburg (Germany); Lawrence Berkeley National Laboratory (United States); Universidade de São Paulo (Brazil)
Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association, volume 22, issue 5, article e71453
Dates: received 20 January 2026; accepted 19 March 2026; published online 10 May 2026; in print May 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1002/alz.71453 · PMID 42108381 · PMCID PMC13158160 · OpenAlex W7160880409
Open access: hybrid, a free copy (OpenAlex)
Status: code on request
Categories: histology / microscopy (modality), PET / SPECT (modality), human (organism), Alzheimer's / dementia (population)
Methods: Connectivity, Statistics, fMRI & imaging, Smoothing, state filtering, decompositions
Keywords: correlation, digital immunohistochemistry, flortaucipir, neuropathology, PET, tau
MeSH: Alzheimer Disease*, Brain*, Carbolines*, Positron-Emission Tomography*, tau Proteins*, Aged, Aged, 80 and over, Female, Humans, Immunohistochemistry, Male (* major topic)
Topic: Alzheimer's disease research and treatments (Physiology, Medicine), according to OpenAlex
Funding: Avid Radiopharmaceuticals (NCT02350634); National Institutes of Health (R01AG070826); BrightFocus Foundation (BrightFocus); National Institute on Aging
Citations: not cited yet (Europe PMC); 37 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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The paper's code and data availability statement is in the Data section.

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Data

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Code and data availability statement

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  • it says that the code is available on request

Read it in the paper: doi.org/10.1002/alz.71453.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 10 authors, 6 keywords, 11 MeSH terms, 4 funders, 37 references.

Cite

This paper

Chao, Y., Chen, Y., Chadwick, T. A., Harrison, T. M., Iaccarino, L., Heinsen, H., Ushizima, D., Tosun, D., Jagust, W. J., & Grinberg, L. T. (2026). Correlation between in vivo <sup>18</sup>F-flortaucipir PET and whole-brain postmortem histological tau signals in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association, 22(5), e71453. https://doi.org/10.1002/alz.71453

BibTeX

@article{chao2026correlation,
author = {Chao, Yishu and Chen, Yuheng and Chadwick, Trevor A. and Harrison, Theresa M. and Iaccarino, Leonardo and Heinsen, Helmut and Ushizima, Daniela and Tosun, Duygu and Jagust, William J. and Grinberg, Lea T.},
title = {{Correlation between in vivo \<sup\>18\</sup\>F-flortaucipir PET and whole-brain postmortem histological tau signals in Alzheimer's disease}},
journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
year = {2026},
month = may,
volume = {22},
number = {5},
pages = {e71453},
publisher = {Wiley},
issn = {1552-5260},
doi = {10.1002/alz.71453},
url = {https://doi.org/10.1002/alz.71453},
pmid = {42108381},
pmcid = {PMC13158160}
}

RIS

TY - JOUR
AU - Chao, Yishu
AU - Chen, Yuheng
AU - Chadwick, Trevor A.
AU - Harrison, Theresa M.
AU - Iaccarino, Leonardo
AU - Heinsen, Helmut
AU - Ushizima, Daniela
AU - Tosun, Duygu
AU - Jagust, William J.
AU - Grinberg, Lea T.
TI - Correlation between in vivo <sup>18</sup>F-flortaucipir PET and whole-brain postmortem histological tau signals in Alzheimer's disease
T2 - Alzheimer's & dementia : the journal of the Alzheimer's Association
J2 - Alzheimers Dement
PY - 2026
DA - 2026/05/01
VL - 22
IS - 5
SP - e71453
SN - 1552-5260
PB - Wiley
DO - 10.1002/alz.71453
UR - https://doi.org/10.1002/alz.71453
LA - en
ER -

CSL-JSON

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