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Stable neuronal representations underlie cognitive resilience to Alzheimer's disease pathology.

Overview

Authors: Keying Chen1,2, Emma Pineau1,2,3, Margaret Koletar1,2, Andrea Trevisiol1,2, Jack Simiao He4, Mary Hill2,5, Maged Goubran1,2,3,6, John Sled3,7,8,9, JoAnne McLaurin2,5,10, Bojana Stefanovic1,2,3
  1. Physical Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada
  2. Hurvitz Brain Sciences, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
  3. Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
  4. Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada
  5. Biological Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada
  6. Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
  7. Mouse Imaging Centre, The Hospital for Sick Children, Toronto, Ontario, Canada
  8. Translational Medicine, SickKids Research Institute, Toronto, Ontario, Canada
  9. Department of Obstetrics & Gynecology, University of Toronto, Toronto, Ontario, Canada
  10. Department of Laboratory Medicine and Pathobiology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Institutions: Sunnybrook Health Science Centre (Canada); Sunnybrook Research Institute; University of Toronto (Canada); McMaster University (Canada); Sunnybrook Hospital (Canada); Harquail Centre for Neuromodulation (Canada); Hospital for Sick Children (Canada); SickKids Foundation (Canada); Sickkids Research Institute (Canada)
Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association, volume 22, issue 6, article e71570
Dates: received 23 January 2026; accepted 6 May 2026; published online 7 June 2026; in print June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1002/alz.71570 · PMID 42252511 · PMCID PMC13243190 · OpenAlex W7163807529
Open access: hybrid, a free copy (OpenAlex)
Status: code on request
Categories: rat (organism), Alzheimer's / dementia (population)
Methods: Spectral & time-frequency, Statistics, Preprocessing, Evoked potentials, Connectivity, Single-unit activity, calcium imaging, Physiology & signal measures
Keywords: Alzheimer's disease, cognitive resilience, excitatory‐inhibitory balance, functional connectivity, neuronal ensemble representations, ultrahigh‐density electrophysiology
MeSH: Alzheimer Disease*, Cognition*, Neurons*, Animals, Disease Models, Animal, Hippocampus, Male, Maze Learning, Rats, Rats, Inbred F344 (* major topic)
Topic: Functional Brain Connectivity Studies (Cognitive Neuroscience, Neuroscience), according to OpenAlex
Funding: Canadian Institutes of Health Research (CIHR PJT191806); NIH HHS (NIH R01AG084681); CIHR (CIHR PJT191806); National Institutes of Health (NIH R01AG084681); the Canadian Consortium on Neurodegeneration in Aging
Citations: cited by 1 paper (Europe PMC); 83 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

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Code and data availability statement

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Read it in the paper: doi.org/10.1002/alz.71570.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 10 authors, 6 keywords, 10 MeSH terms, 5 funders, 82 references.

Cite

This paper

Chen, K., Pineau, E., Koletar, M., Trevisiol, A., He, J. S., Hill, M., Goubran, M., Sled, J., McLaurin, J., & Stefanovic, B. (2026). Stable neuronal representations underlie cognitive resilience to Alzheimer's disease pathology. Alzheimer's & dementia : the journal of the Alzheimer's Association, 22(6), e71570. https://doi.org/10.1002/alz.71570

BibTeX

@article{chen2026stable,
author = {Chen, Keying and Pineau, Emma and Koletar, Margaret and Trevisiol, Andrea and He, Jack Simiao and Hill, Mary and Goubran, Maged and Sled, John and McLaurin, JoAnne and Stefanovic, Bojana},
title = {{Stable neuronal representations underlie cognitive resilience to Alzheimer's disease pathology}},
journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
year = {2026},
month = jun,
volume = {22},
number = {6},
pages = {e71570},
publisher = {Wiley},
issn = {1552-5260},
doi = {10.1002/alz.71570},
url = {https://doi.org/10.1002/alz.71570},
pmid = {42252511},
pmcid = {PMC13243190}
}

RIS

TY - JOUR
AU - Chen, Keying
AU - Pineau, Emma
AU - Koletar, Margaret
AU - Trevisiol, Andrea
AU - He, Jack Simiao
AU - Hill, Mary
AU - Goubran, Maged
AU - Sled, John
AU - McLaurin, JoAnne
AU - Stefanovic, Bojana
TI - Stable neuronal representations underlie cognitive resilience to Alzheimer's disease pathology
T2 - Alzheimer's & dementia : the journal of the Alzheimer's Association
J2 - Alzheimers Dement
PY - 2026
DA - 2026/06/01
VL - 22
IS - 6
SP - e71570
SN - 1552-5260
PB - Wiley
DO - 10.1002/alz.71570
UR - https://doi.org/10.1002/alz.71570
LA - en
ER -

CSL-JSON

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"DOI": "10.1002/alz.71570",
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"language": "en",
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