Correspondence between morphological similarity of the left lateral orbitofrontal cortex and neurotransmitter systems in adolescent males with autism.
The 6 matches · 4 of them tie a paragraph to a whole file, not to given lines: weak matches, whose lines are not tinted
- [1] § METHODS › Statistical analysis › Cross‐family correction and effect size estimation ↔ step4_across_family_correction_code/neurotransmitter_code.m, the whole file · a weak match · score 0.63 · family FDR, Bonferroni Holm
- [2] § RESULTS › Cross‐family correction and effect size estimation ↔ step4_across_family_correction_code/neurotransmitter_code.m, the whole file · a weak match · score 0.56 · family correction, Bonferroni Holm
- [3] § RESULTS › Cross‐family correction and effect size estimation ↔ step4_across_family_correction_code/Bonferroni_Holm.m, lines 1–29 · score 0.55 · Bonferroni Holm, family correction
- [4] § RESULTS › Medication sensitivity analysis ↔ step6_MED_sensitivity_code.m, the whole file · a weak match · score 0.51 · medicated ASD, OFC degree, sensitivity, drug, Cohen, TD
- [5] § METHODS › Statistical analysis › Cross‐family correction and effect size estimation ↔ step4_across_family_correction_code/Bonferroni_Holm.m, lines 1–29 · score 0.51 · Bonferroni Holm, family
- [6] § RESULTS › Reproducibility analysis results ↔ step7_reproductivity/weighted_network.m, the whole file · a weak match · score 0.50 · weighted MBNs, weighted network, robustness, reproducibility, node
Paper
Loaded from Europe PMC by your browser, not stored by OSCR: doi.org · Europe PMC
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The authors' code
MATLAB · 60 lines · 2.1 KB · no license · 2 matches
neurotransmitter_code.m at commit 06c368e, no license · at the source
Overview
- Institute for Brain Research and Rehabilitation, South China Normal University, Guangzhou, Guangdong, China
- School of Medicine, Foshan University, Foshan, Guangdong, China
- Key Laboratory of Brain, Cognition and Education Sciences, Ministry of Education, Guangzhou, Guangdong, China
- Center for Studies of Psychological Application, South China Normal University, Guangzhou, Guangdong, China
- Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou, Guangdong, China
Abstract
Background: Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by pronounced heterogeneity in brain structure, which limits the development of targeted interventions. Morphological brain networks (MBNs) enable the mapping of coordinated structural features across brain regions at the individual level. However, the specific organisation of such networks in ASD and their potential relationships with underlying neurotransmitter systems remain largely unexplored.
Aims: To characterise alterations in cortical thickness‐based MBNs among adolescent males with ASD and to test whether these network changes spatially correspond to normative positron emission tomography‐derived neurotransmitter receptor/
Methods: In this cross‐sectional study, T1‐weighted magnetic resonance imaging (MRI) data from 424 adolescent males (207 with ASD, 217 typically developing) in the Autism Brain Imaging Data Exchange were analysed. MBNs were constructed using interregional cortical thickness similarity quantified by Jensen–Shannon divergence. Graph theoretical metrics were computed, and group differences were assessed with permutation tests controlling for age and intelligence quotient (IQ). Spatial correlations between left lateral orbitofrontal morphological similarity and atlas‐based neurotransmitter maps were investigated using the JuSpace toolbox.
Results: The ASD group exhibited a significantly increased normalised clustering coefficient (t = 2.40, p = 0.020) and decreased nodal centrality in the left lateral orbitofrontal cortex (OFC). This region showed reduced morphological similarity with 65 other brain regions. Furthermore, the OFC‐based similarity patterns were significantly associated with the spatial distributions of gamma‐aminobutyric acid type A (GABAa), 5‐hydroxytryptamine receptor 1A (5‐HT1a) and μ‐opioid receptor systems (r = 0.22, p = 0.017, spin‐corrected). These alterations were robust to stringent cross‐family correction.
Conclusions: These findings highlight the left lateral OFC as a structural key hub in adolescent males with ASD. The robustness of these OFC‐centred network alterations under stringent cross‐family correction, together with their associations with neurotransmitter systems, provides a potential neurobiological basis for targeted interventions in this population.
Reproduced under the paper's license (CC BY-NC), from the paper cited above.
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juryxy/JuSpace
99c08a889b292d1f28a89aa12df25663243f16c8, 8 June 2026Availability: 1 check, the latest on 26 September 2026: the link answers
- 26 September 2026: the link answers
21 files, not copied: shown from their source
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JuSpace.m — MATLAB, 1,154 lines, shown from its source - JuSpace_v2/
append_prefix_to_fileNam — MATLAB, 13 lines, shown from its sourcees_my.m - JuSpace_v2/
cell2num_my.m — MATLAB, 29 lines, shown from its source - JuSpace_v2/
center_of_mass_my.m — MATLAB, 26 lines, shown from its source - JuSpace_v2/
compute_DomainGauges.m — MATLAB, 315 lines, shown from its source - JuSpace_v2/
compute_exact_pvalue.m — MATLAB, 163 lines, shown from its source - JuSpace_v2/
compute_exact_spatial_pv — MATLAB, 227 lines, shown from its sourcealue.m - JuSpace_v2/
fdr_bh.m — MATLAB, 58 lines, shown from its source - JuSpace_v2/
fishers_r_to_z.m — MATLAB, 3 lines, shown from its source - JuSpace_v2/
fishers_z_to_r.m — MATLAB, 3 lines, shown from its source - JuSpace_v2/
generate_colors_blue_my. — MATLAB, 9 lines, shown from its sourcem - JuSpace_v2/
generate_colors_nice_my. — MATLAB, 54 lines, shown from its sourcem - JuSpace_v2/
generate_spatial_nullMap — MATLAB, 250 lines, shown from its sources.m - JuSpace_v2/
isemptycell.m — MATLAB, 16 lines, shown from its source - JuSpace_v2/
mean_time_course.m — MATLAB, 50 lines, shown from its source - JuSpace_v2/
num2cell_my.m — MATLAB, 14 lines, shown from its source - JuSpace_v2/
removenan_my.m — MATLAB, 28 lines, shown from its source - JuSpace_v2/
resize_img_useTemp_imcal — MATLAB, 17 lines, shown from its sourcec.m - JuSpace_v2/
run_JuSpace.sh — Shell, 36 lines, shown from its source - JuSpace_v2/
select_con_maps_forfMRI_ — MATLAB, 39 lines, shown from its sourcemy.m - README.md — Text, 137 lines, shown from its source
Huashuang1221/ASD
06c368e3adc3912a6cafd8aecc7ce2cc6f1e0a3a, 9 January 2026Availability: 1 check, the latest on 29 September 2026: the link answers
- 29 September 2026: the link answers
15 files, not copied: shown from their source
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on.m — MATLAB, 96 lines, shown from its source - step2_LMM_code/
LMM_betweenness_OFC_code — MATLAB, 95 lines, shown from its source.m - step2_LMM_code/
LMM_degree_OFC_code.m — MATLAB, 147 lines, shown from its source - step2_LMM_code/
LMM_pagerank_OFC_code.m — MATLAB, 161 lines, shown from its source - step3_corr_trans.m — MATLAB, 1 line, shown from its source
- step4_across_family_corr
ection_code/ — MATLAB, 51 lines, 2 matches, shown from its sourceBonferroni_Holm.m - step4_across_family_corr
ection_code/ — MATLAB, 64 lines, shown from its sourceedge_correction_code.m - step4_across_family_corr
ection_code/ — MATLAB, 35 lines, shown from its sourceglobal.m - step4_across_family_corr
ection_code/ — MATLAB, 60 lines, 2 matches, shown from its sourceneurotransmitter_code.m - step4_across_family_corr
ection_code/ — MATLAB, 95 lines, shown from its sourcenode_correction_code.m - step5_effect_size_code.m
— MATLAB, 82 lines, shown from its source - step6_MED_sensitivity_co
de.m — MATLAB, 40 lines, 1 match, shown from its source - step7_reproductivity/
bootstrap_CV_code.m — MATLAB, 74 lines, shown from its source - step7_reproductivity/
weighted_network.m — MATLAB, 16 lines, 1 match, shown from its source - README.md — Text, 52 lines, shown from its source
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Data availability statement
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Recorded: type, language, journal, volume, issue, pages, dates, 8 authors, 5 keywords, 82 references.
Cite
This paper
Zhang, H., Li, J., Hou, C., Huang, Y., Ma, L., Xiong, B., Wang, J., & Weng, X. (2026). Correspondence between morphological similarity of the left lateral orbitofrontal cortex and neurotransmitter systems in adolescent males with autism. General psychiatry, 39(2), e70014. https://
BibTeX
@article{zhang2026corres
author = {Zhang, Huashuang and Li, Junle and Hou, Chensheng and Huang, Yilin and Ma, Lisha and Xiong, Bincan and Wang, Jinhui and Weng, Xuchu},
title = {{Correspondence between morphological similarity of the left lateral orbitofrontal cortex and neurotransmitter systems in adolescent males with autism}},
journal = {General psychiatry},
year = {2026},
month = apr,
volume = {39},
number = {2},
pages = {e70014},
publisher = {Shanghai Mental Health Center},
issn = {2517-729X},
doi = {10.1002/
url = {https://
pmid = {42005723},
pmcid = {PMC13090103}
}
RIS
TY - JOUR
AU - Zhang, Huashuang
AU - Li, Junle
AU - Hou, Chensheng
AU - Huang, Yilin
AU - Ma, Lisha
AU - Xiong, Bincan
AU - Wang, Jinhui
AU - Weng, Xuchu
TI - Correspondence between morphological similarity of the left lateral orbitofrontal cortex and neurotransmitter systems in adolescent males with autism
T2 - General psychiatry
J2 - Gen Psychiatr
PY - 2026
DA - 2026/
VL - 39
IS - 2
SP - e70014
SN - 2517-729X
PB - Shanghai Mental Health Center
DO - 10.1002/
UR - https://
LA - en
ER -
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