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Neuroimaging Correlates of Post-Stroke Pain After Ischemic Stroke: Secondary Analysis of the INSPiRE-TMS Trial.

Code ↔ Paper

7 matches between paragraphs of the paper and lines of its authors' code, computed by the harvester (lexical-v1). Click a colored paragraph or line to see its counterpart.

The 7 matches · 3 of them tie a paragraph to a whole file, not to given lines: weak matches, whose lines are not tinted
  1. [1] § Methods › Neuroimaging Analysis › Preprocessing ↔ ea_normalize_fsl.m, the whole file · a weak match · score 0.84 · FMRIB Software Library, nonlinear registrations, MNI space, MR imaging, FSL, SyN
  2. [2] § Methods › Neuroimaging Analysis › Preprocessing ↔ ea_normalize_ants.m, the whole file · a weak match · score 0.70 · Advanced Normalization Tools, MNI space, MR imaging, SyN, nonlinear, modalities
  3. [3] § Results › Neuroimaging Results › Lesion Network Mapping ↔ explorers/networkmapping_explorer/ea_networkmapping.m, lines 1–74 · score 0.65 · Lesion network mapping, left hemisphere, right hemisphere, permutation, RH, LH
  4. [4] § Methods › Statistical Analysis ↔ ext_libs/corr/ea_skipped_correlation.m, the whole file · a weak match · score 0.54 · confidence intervals, Bivariate, CI, variables, V1
  5. [5] § Results › Neuroimaging Results › Lesion Network Mapping ↔ explorers/unifiedmapping_explorer/ea_unifiedmapping.m, lines 1–116 · score 0.53 · left hemisphere, right hemisphere, permutation, RH, LH, correlations
  6. [6] § Methods › Imaging ↔ ext_libs/dicm2nii/dicm_dict.m, lines 146–205 · score 0.50 · inversion recovery, flight, protocol, Sequences, MR, patients
  7. [7] § Methods › Neuroimaging Analysis › Lesion Network Mapping ↔ connectomics/mapper/cs_fmri_conseed_matrix_matrix.m, lines 1–138 · score 0.50 · fMRI, binarized, seeds, connectivity, binary, voxels

Paper

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The authors' code

MATLAB · 59 lines · 2.9 KB · GPL-3.0 · 1 match

  1. function varargout=ea_normalize_fsl(options)
  2. % This is a function that normalizes both a copy of transversal and coronal
  3. % images into MNI-space. The goal was to make the procedure both robust and
  4. % automatic, but still, it must be said that normalization results should
  5. % be taken with much care because all reconstruction results heavily depend
  6. % on these results. Normalization of DBS-MR-images is especially
  7. % problematic since usually, the field of view doesn't cover the whole
  8. % brain (to reduce SAR-levels during acquisition) and since electrode
  9. % artifacts can impair the normalization process. Therefore, normalization
  10. % might be best archieved with other tools that have specialized on
  11. % normalization of such image data.
  12. %
  13. % The procedure used here uses the ANTs Syn approach to map a patient's
  14. % brain to MNI space directly.
  15. % __________________________________________________________________________________
  16. % Copyright (C) 2015 Charite University Medicine Berlin, Movement Disorders Unit
  17. % Andreas Horn
  18. if ischar(options) % return name of method.
  19. varargout{1}='FNIRT (Andersson 2010)';
  20. varargout{2}=1; % dummy output
  21. varargout{3}=1; % hassettings.
  22. varargout{4}=0; % is multispectral
  23. return
  24. end
  25. % FSL FNIRT nonlinear registration
  26. ea_fnirt([ea_space, options.primarytemplate, '.nii'],...
  27. options.subj.coreg.anat.preop.(options.subj.AnchorModality),...
  28. options.subj.norm.anat.preop.(options.subj.AnchorModality));
  29. % Clean up FNIRT log file
  30. logFileBase = ea_niifileparts(options.subj.coreg.anat.preop.(options.subj.AnchorModality));
  31. ea_delete([logFileBase, '_to_*.log']);
  32. % Move transformation file
  33. transformBase = ea_niifileparts(options.subj.norm.anat.preop.(options.subj.AnchorModality));
  34. transform = dir([transformBase, 'WarpField*']);
  35. ext = regexp(transform(end).name, '(?<=WarpField)\.nii(\.gz)?$', 'match', 'once');
  36. movefile([transformBase, 'WarpField', ext], [options.subj.norm.transform.forwardBaseName, 'fnirt', ext]);
  37. movefile([transformBase, 'InverseWarpField', ext], [options.subj.norm.transform.inverseBaseName, 'fnirt', ext]);
  38. % Apply registration
  39. ea_apply_normalization(options)
  40. %% add methods dump:
  41. [scit, lcit] = ea_getspacedefcit;
  42. cits = {
  43. 'Andersson JLR, Jenkinson M, Smith S (2010) Non-linear registration, aka spatial normalisation. FMRIB technical report TR07JA2'
  44. 'Woolrich MW, Jbabdi S, Patenaude B, Chappell M, Makni S, Behrens T, Beckmann C, Jenkinson M, Smith SM (2009) Bayesian analysis of neuroimaging data in FSL. NeuroImage, 45:S173-86'
  45. };
  46. if ~isempty(lcit)
  47. cits = [cits;{lcit}];
  48. end
  49. ea_methods(options,['Pre- (and post-) operative acquisitions were spatially normalized into ',ea_getspace,' space ',scit,' based on the preoperative acquisition (',options.subj.AnchorModality,') using the'...
  50. ' FNIRT approach as implemented in the FMRIB Software Library (Andersson 2010; Woolrich 2009 https://fsl.fmrib.ox.ac.uk/).'],cits);

ea_normalize_fsl.m at commit 5b1008d, under GPL-3.0 · at the source

Overview

Authors: Alina Stegemann1,2,3, Ana Sofia Rios1,2, Ahmed Khalil1,2, Ulrike Grittner3,4, Uchralt Temuulen1,2, Ramanan Ganeshan1,2, Tim Bastian Braemswig1,2,3,5, Andreas Horn6,7, Thomas Ihl1,2, Heinrich J. Audebert1,2, Anna Kufner1,2,3,8, Matthias Endres1,2,5,8,9
  1. Charité – Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin and Humboldt‐Universität Zu Berlin, Klinik für Neurologie Mit Experimenteller Neurologie Berlin Germany
  2. Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt‐Universität Zu Berlin Center for Stroke Research Berlin (CSB) Berlin Germany
  3. Berlin Institute of Health (BIH) at Charité Universitätsmedizin Berlin Berlin Germany
  4. Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt‐Universität Zu Berlin Institute of Biometry and Clinical Epidemiology Berlin Germany
  5. German Centre for Cardiovascular Research (Deutsches Zentrum für Herz Kreislauferkrankungen, DZHK) Berlin Germany
  6. Center for Brain Circuit Therapeutics Department of Neurology, Brigham & Women's Hospital Harvard Medical School Boston Massachusetts USA
  7. MGH Neurosurgery & Center for Neurotechnology and Neurorecovery (CNTR) at MGH Neurology Massachusetts General Hospital Harvard Medical School Boston Massachusetts USA
  8. German Center for Mental Health (Deutsches Zentrum für Psychische Gesundheit, DZPG) Berlin Germany
  9. German Center for Neurodegenerative Diseases (Deutsches Zentrum für Neurode‐ Generative Erkrankungen, DZNE) Berlin Germany
Journal: Human brain mapping, volume 47, issue 10, article e70602
Dates: received 15 December 2025; accepted 30 June 2026; published online 8 July 2026; in print July 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.1002/hbm.70602 · PMID 42420807 · PMCID PMC13345988 · OpenAlex W7167800801
Open access: gold, a free copy (OpenAlex)
Status: code verified
Categories: other (modality), human (organism), other condition (population), stroke (population), pain (population), clinical / translational (subfield)
Methods: Statistics, Machine learning, Connectivity, fMRI & imaging
Keywords: chronic pain, lesion mapping, post‐stroke pain, stroke
MeSH: Anxiety*, Insular Cortex*, Ischemic Stroke*, Nerve Net*, Pain*, Stroke*, Thalamus*, Aged, Brain Mapping, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuroimaging (* major topic)
Topic: Functional Brain Connectivity Studies (Cognitive Neuroscience, Neuroscience), according to OpenAlex
Funding: Berlin Institute of Health; Deutsche Forschungsgemeinschaft (TRR 295‐424778381); Bundesministerium für Bildung und Forschung (Federal Ministry of Education and Research); Deutsches Zentrum für Luft‐ und Raumfahrt; NIH (R01MH130666, 1R01NS127892‐01, 2R01 MH113929, UM1NS132358); New Venture Fund
Citations: not cited yet (Europe PMC); 53 references in the paper

Abstract

Post‐stroke pain (PSP) affects nearly half of stroke survivors, severely compromising quality of life. The causes of PSP remain underexplored, although there is likely a complex interplay of lesion effects, psychological factors, and mobility that play a role in its development. The aim of the study was to investigate clinical characteristics associated with PSP, as well as structural and functional correlates of PSP using lesion symptom (LSM) and network mapping (LNM). We analyzed data from the INSPiRE‐TMS cohort, encompassing 1022 minor ischemic stroke patients. Pain severity and psychological factors (EQUATION 5D‐3L questionnaire) were assessed annually for up to 3 years. In a sub‐group of 391 patients with available imaging data, LSM and LNM analyses were conducted to identify neural correlates of PSP. Overall, 47% of patients reported pain 1‐year post‐stroke. Multivariable regression analyses identified baseline anxiety as associated with PSP assessed at 1‐year post‐stroke (OR 2.90, 95% CI 1.17–7.17, p = 0.021). LSM did not identify any voxels associated with new severe pain. LNM identified a network involving the anterior cingulate cortex, thalamus, and insular cortex. Adjusting for anxiety highlighted distinct network contributions, suggesting interactive effects of psychological states on pain perception. Automated comparison to large metanalytical findings using Neurosynth associated the terms ‘pain’ and ‘nociception’ most strongly to the identified network. PSP is closely associated with psychological factors such as anxiety. LNM of PSP revealed disruptions in a pain‐related neural network consistent with prior pain research. These results warrant external validation and could guide future network‐targeted neuromodulation therapies.

Trial Registration: ClinicalTrials.gov identifier: NCT01586702

Reproduced under the paper's license (CC BY), from the paper cited above.

Repository

Its files are read in the Code ↔ Paper reader above, with 7 matches between paragraphs and lines of code.

netstim/leaddbs

License: GPL-3.0
State: the link answers, verified on 27 September 2026
Evidence: files inventoried
Commit: 5b1008d705e97fe0c8f693dece14455607f4afac, 2 March 2026
Languages: MATLAB (2362), Python (101), C++ (30), C (29), Shell (10), C/C++ (4), Java (3)
Size: 6,260 files, 2,539 scripts
Software Heritage: archived
Found in: “Data Availability Statement”
Holds: README, license file, CITATION.cff, environment (ext_libs/PaCER/docs/requirements.txt), documentation
Not found: tests, continuous integration
Tools: SPM (121 files), Statistics and Machine Learning Toolbox (84 files), Tools for NIfTI and ANALYZE image (MATLAB) (38 files), Image Processing Toolbox (36 files), NumPy (35 files), FieldTrip (24 files), h5py (12 files), SciPy (8 files), FreeSurfer (7 files), cifti-matlab (6 files), Signal Processing Toolbox (6 files), Matplotlib (6 files), Parallel Computing Toolbox (5 files), pandas (5 files), TensorFlow (4 files), Keras (3 files), Optimization Toolbox (3 files), ANTs (2 files), export_fig (2 files), GIfTI library for MATLAB (2 files), NiBabel (2 files), Psychtoolbox (2 files), CAT12 (1 file), Curve Fitting Toolbox (1 file), pydicom (1 file), seaborn (1 file)
Availability: 1 check, the latest on 27 September 2026: the link answers
  • 27 September 2026: the link answers
2,000 files

The paper's code and data availability statement is in the Data section.

Tracing map

Proposed by the machine: these links were found in the paper and verified at the source, without human review. The map will receive a Zenodo DOI once one of the paper's authors has validated it with their ORCID.

What the map holds:

  • 1 repository of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
  • 1,998 scripts, each with its path and the digest of its content;
  • 7 matches between paragraphs of the paper and lines of the code (method lexical-v1);
  • neither the text of the paper nor the code itself.

Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

No dataset and no data link were found in the paper.

Data Availability Statement

Data supporting the results of this study are available upon request from the corresponding author. Open source software tools were used for the pre‐processing and analysis of the data, including: Lead‐DBS (https://github.com/netstim/leaddbs), FSL 6.0.6.4 (https://fsl.fmrib.ox.ac.uk/fsl/fslwiki/) and ANTsPy (https://github.com/ANTsX/ANTsPy).

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 12 authors, 4 keywords, 15 MeSH terms, 6 funders, 52 references.

Cite

This paper

Stegemann, A., Rios, A. S., Khalil, A., Grittner, U., Temuulen, U., Ganeshan, R., Braemswig, T. B., Horn, A., Ihl, T., Audebert, H. J., Kufner, A., & Endres, M. (2026). Neuroimaging Correlates of Post-Stroke Pain After Ischemic Stroke: Secondary Analysis of the INSPiRE-TMS Trial. Human brain mapping, 47(10), e70602. https://doi.org/10.1002/hbm.70602

BibTeX

@article{stegemann2026neuroimaging,
author = {Stegemann, Alina and Rios, Ana Sofia and Khalil, Ahmed and Grittner, Ulrike and Temuulen, Uchralt and Ganeshan, Ramanan and Braemswig, Tim Bastian and Horn, Andreas and Ihl, Thomas and Audebert, Heinrich J. and Kufner, Anna and Endres, Matthias},
title = {{Neuroimaging Correlates of Post-Stroke Pain After Ischemic Stroke: Secondary Analysis of the INSPiRE-TMS Trial}},
journal = {Human brain mapping},
year = {2026},
month = jul,
volume = {47},
number = {10},
pages = {e70602},
publisher = {Wiley},
issn = {1065-9471},
doi = {10.1002/hbm.70602},
url = {https://doi.org/10.1002/hbm.70602},
pmid = {42420807},
pmcid = {PMC13345988}
}

RIS

TY - JOUR
AU - Stegemann, Alina
AU - Rios, Ana Sofia
AU - Khalil, Ahmed
AU - Grittner, Ulrike
AU - Temuulen, Uchralt
AU - Ganeshan, Ramanan
AU - Braemswig, Tim Bastian
AU - Horn, Andreas
AU - Ihl, Thomas
AU - Audebert, Heinrich J.
AU - Kufner, Anna
AU - Endres, Matthias
TI - Neuroimaging Correlates of Post-Stroke Pain After Ischemic Stroke: Secondary Analysis of the INSPiRE-TMS Trial
T2 - Human brain mapping
J2 - Hum Brain Mapp
PY - 2026
DA - 2026/07/01
VL - 47
IS - 10
SP - e70602
SN - 1065-9471
PB - Wiley
DO - 10.1002/hbm.70602
UR - https://doi.org/10.1002/hbm.70602
LA - en
ER -

CSL-JSON

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"container-title": "Human brain mapping",
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{
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