Stress-Adaptive Biomaterials With Tunable Yielding Architectures Regulate Organoid Morphogenesis.
Overview
- Department of Chemical Engineering McGill University Montreal Quebec Canada
- Department of Chemistry McGill University Montreal Quebec Canada
- Department of Biological and Biomedical Engineering McGill University Montreal Quebec Canada
- Early Drug Discovery Unit (EDDU), Montreal Neurological Institute and Hospital McGill University Montreal Quebec Canada
- Rosalind and Morris Goodman Cancer Institute McGill University Montreal Quebec Canada
- School of Biomedical Engineering University of British Columbia Vancouver British Columbia Canada
- International Collaboration on Repair Discoveries, Vancouver Coastal Health Research Institutes Vancouver, British Columbia Canada
Abstract
The yield stress at which biomaterials undergo plastic deformation limits the stresses that can be developed in encapsulated growing tissues. While matrix mechanical properties such as stiffness and viscoelasticity have a profound effect on cells, the role of yield stress has remained challenging to define. Here, we design a granular hydrogel platform with supramolecular host‐guest dynamic crosslinkers to precisely and quantitatively tune the stress at which the matrix repeatedly yields and reconfigures around tissues as they grow. Designed to provide similar mechanical constraints as a mesh stress ball, matrix yield stresses can be tuned between 12 and 370 Pa, while maintaining a storage modulus below ∼0.1 kPa. Our study suggests that this range of yield stress is sufficient to promote or limit peripheral shedding in a model of non‐adhesive cancer migration, and that early development of midbrain organoids is exquisitely sensitive to these matrix mechanics. Yield stresses of only 25 Pa promoted bud‐like protrusions and large, luminized neural rosettes, while variations as small as 10 Pa limited these phenotypes. These studies indicate that morphogenesis and tissue organization can be controlled via the material's yield stress, suggesting a new mechanical parameter to target in designing biomaterials for disease modeling and regenerative medicine.
Reproduced under the paper's license (CC BY-NC), from the paper cited above.
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Data Availability Statement
Source data is maintained in an Open Science Framework repository that can be accessed at: https://
Reproduced under the paper's license (CC BY-NC), from the paper cited above.
Versions
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Version 2, 28 September 2026
- Publisher: n/a → Wiley
Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 8 authors, 9 keywords, 6 MeSH terms, 7 funders, 55 references.
Cite
This paper
Reeves, J. P. W., Rostami, S., Rammal, M., Bocan, A., Lépine, P., Harrington, M. J., Durcan, T. M., & Moraes, C. (2026). Stress-Adaptive Biomaterials With Tunable Yielding Architectures Regulate Organoid Morphogenesis. Small (Weinheim an der Bergstrasse, Germany), 22(50), e74538. https://
BibTeX
@article{reeves2026stres
author = {Reeves, James P. W. and Rostami, Sabra and Rammal, Mostafa and Bocan, Andrei and Lépine, Paula and Harrington, Matthew J. and Durcan, Thomas M. and Moraes, Christopher},
title = {{Stress-Adaptive Biomaterials With Tunable Yielding Architectures Regulate Organoid Morphogenesis}},
journal = {Small (Weinheim an der Bergstrasse, Germany)},
year = {2026},
month = jul,
volume = {22},
number = {50},
pages = {e74538},
publisher = {Wiley},
issn = {1613-6810},
doi = {10.1002/
url = {https://
pmid = {42434933},
pmcid = {PMC13548924}
}
RIS
TY - JOUR
AU - Reeves, James P. W.
AU - Rostami, Sabra
AU - Rammal, Mostafa
AU - Bocan, Andrei
AU - Lépine, Paula
AU - Harrington, Matthew J.
AU - Durcan, Thomas M.
AU - Moraes, Christopher
TI - Stress-Adaptive Biomaterials With Tunable Yielding Architectures Regulate Organoid Morphogenesis
T2 - Small (Weinheim an der Bergstrasse, Germany)
J2 - Small
PY - 2026
DA - 2026/
VL - 22
IS - 50
SP - e74538
SN - 1613-6810
PB - Wiley
DO - 10.1002/
UR - https://
LA - en
ER -
CSL-JSON
{
"id": "10.1002/
"type": "article-journal",
"title": "Stress-Adaptive Biomaterials With Tunable Yielding Architectures Regulate Organoid Morphogenesis",
"container-title": "Small (Weinheim an der Bergstrasse, Germany)",
"author": [
{
"family": "Reeves",
"given": "James P. W."
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"family": "Lépine",
"given": "Paula"
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"family": "Harrington",
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"family": "Moraes",
"given": "Christopher"
}
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"volume": "22",
"issue": "50",
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"DOI": "10.1002/
"PMID": "42434933",
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"ISSN": "1613-6810",
"publisher": "Wiley",
"URL": "https://
"language": "en",
"issued": {
"date-parts": [
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}
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