Plasma phosphorylated tau biomarkers map onto [^18F]FDG PET hypometabolism: a voxel-wise study in a clinical cohort with CSF-confirmed AD subgroup analysis.
Overview
- Department of Biomedicine and Prevention, University of Rome Tor Vergata,Rome, Italy
- IRCCS Neuromed,Pozzilli, Italy
- Memory Clinic and Neurodegenerative Dementia Research Unit, Policlinico Tor Vergata, University of Rome Tor Vergata,Rome, Italy
- Nuclear Medicine Unit, Policlinico Tor Vergata,Rome, Italy
Abstract
Purpose: To examine voxel-wise associations between plasma phosphorylated tau biomarkers and cerebellum-normalised [^18F]fluorodeoxyglucose
Methods: One hundred consecutive patients who underwent brain [^18F]FDG PET and plasma biomarker assessment within ≤ 6 months were included. Images were spatially normalised, smoothed, and divided voxel-wise by a subject-specific bilateral cerebellar reference value derived from Automated Anatomical Labelling 3 (AAL3) cerebellar regions. Voxel-wise multiple regressions tested associations with plasma Aβ42/
Results: In the full cohort, plasma p-tau181 and p-tau181/
Conclusions: After voxel-wise cerebellar normalisation, plasma p-tau181/
Supplementary information: The online version contains supplementary material available at 10.1007/
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
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Versions
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Version 2, 28 September 2026
- Publisher: n/a → Springer Science+Business Media
Version 1, 28 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 7 authors, 10 keywords, 11 MeSH terms, 1 funder, 24 references.
Cite
This paper
Chiaravalloti, A., Motta, C., Bonomi, C. G., Poli, M., Di Russo, C., Schillaci, O., & Martorana, A. (2026). Plasma phosphorylated tau biomarkers map onto [^18F]FDG PET hypometabolism: a voxel-wise study in a clinical cohort with CSF-confirmed AD subgroup analysis. European journal of nuclear medicine and molecular imaging, 53(10), 5699-5708. https://
BibTeX
@article{chiaravalloti20
author = {Chiaravalloti, Agostino and Motta, Caterina and Bonomi, Chiara Giuseppina and Poli, Martina and Di Russo, Carmela and Schillaci, Orazio and Martorana, Alessandro},
title = {{Plasma phosphorylated tau biomarkers map onto [\textasciicircum{}18F]F
journal = {European journal of nuclear medicine and molecular imaging},
year = {2026},
month = may,
volume = {53},
number = {10},
pages = {5699--5708},
publisher = {Springer Science+Business Media},
issn = {1619-7070},
doi = {10.1007/
url = {https://
pmid = {42191948},
pmcid = {PMC13421210}
}
RIS
TY - JOUR
AU - Chiaravalloti, Agostino
AU - Motta, Caterina
AU - Bonomi, Chiara Giuseppina
AU - Poli, Martina
AU - Di Russo, Carmela
AU - Schillaci, Orazio
AU - Martorana, Alessandro
TI - Plasma phosphorylated tau biomarkers map onto [^18F]FDG PET hypometabolism: a voxel-wise study in a clinical cohort with CSF-confirmed AD subgroup analysis
T2 - European journal of nuclear medicine and molecular imaging
J2 - Eur J Nucl Med Mol Imaging
PY - 2026
DA - 2026/
VL - 53
IS - 10
SP - 5699
EP - 5708
SN - 1619-7070
PB - Springer Science+Business Media
DO - 10.1007/
UR - https://
LA - en
ER -
CSL-JSON
{
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"title": "Plasma phosphorylated tau biomarkers map onto [^18F]FDG PET hypometabolism: a voxel-wise study in a clinical cohort with CSF-confirmed AD subgroup analysis",
"container-title": "European journal of nuclear medicine and molecular imaging",
"author": [
{
"family": "Chiaravalloti",
"given": "Agostino"
},
{
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"given": "Caterina"
},
{
"family": "Bonomi",
"given": "Chiara Giuseppina"
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{
"family": "Poli",
"given": "Martina"
},
{
"family": "Di Russo",
"given": "Carmela"
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{
"family": "Schillaci",
"given": "Orazio"
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{
"family": "Martorana",
"given": "Alessandro"
}
],
"container-title-short":
"volume": "53",
"issue": "10",
"page": "5699-5708",
"DOI": "10.1007/
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"PMCID": "PMC13421210",
"ISSN": "1619-7070",
"publisher": "Springer Science+Business Media",
"URL": "https://
"language": "en",
"issued": {
"date-parts": [
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}
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