Plasma p-tau217 and glucose metabolism correlate in neocortical association areas in Alzheimer's disease.
Overview
18 affiliations
- ADM Diagnostics, Inc., Northbrook, IL 60062, USA
- Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, 43180 Mölndal, Sweden
- Department of Translational Dementia Research, German Center for Neurodegenerative Diseases (DZNE) Bonn, 53127 Bonn, Germany
- Clinic of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn, 53127 Bonn, Germany
- Department of Neurology, Icahn School of Medicine at Mount Sinai, NewYork, NY 10029, USA
- Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, NewYork, NY 10029, USA
- The Alzheimer's Drug Discovery Foundation, NewYork, NY 10019, USA
- Banner Alzheimer's Institute, University of Arizona, Phoenix, AZ 85006, USA
- Banner Sun Health Research Institute, Sun City, AZ 85351, USA
- Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53792, USA
- Department of Neurodegenerative Disease, UCL Institute of Neurology, London WC1N 3BG, UK
- Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal S-431 80, Sweden
- Department and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705-2281, USA
- UK Dementia Research Institute at UCL, London WC1E 6BT, UK
- Hong Kong Center for Neurodegenerative Diseases, InnoHK, Hong Kong, China
- Centre for Brain Research, Indian Institute of Science, Bangalore 560012, Karnataka, India
- Sanford Grossman Interdisciplinary Program I Neural Circuitry and Immune Function, Icahn School of Medicine at Mount Sinai, NewYork, NY 10029, USA
- Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, NewYork, NY 10029, USA
Abstract
While the biomarkers available for Alzheimer's disease are continually expanding, including clinically approved blood tests, not all of the relationships between various biomarkers have been fully elucidated. In this study, we explore how regional brain metabolism, as measured by fludeoxyglucose-18 (FDG)-PET, relates to plasma biomarkers such as p-tau217, Glial fibrillary acidic protein (GFAP), phosphorylated-tau (p-tau)217/
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
No file of the authors' code could be read here: it is described below, and read at its source.
lnkoenig/ptau-217-and-FDG-PET-AD-official-copy
Availability: 1 check, the latest on 30 September 2026: the link is dead
- 30 September 2026: the link is dead
lnkoenig/ptau-217-and-FDG-PET-AD—official-copy
Availability: 1 check, the latest on 30 September 2026: the link is dead
- 30 September 2026: the link is dead
The paper's code and data availability statement is in the Data section.
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Data
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Data availability
Anonymized data will be shared by request from a qualified academic investigator for the sole purpose of replicating procedures and results presented in the article, and as long as data transfer is in agreement with the IRB of the involved institutions, which should be regulated in a material transfer agreement. Code that was generated for these analyses is available at https://
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 1, 30 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 13 authors, 5 keywords, 19 funders, 68 references.
Cite
This paper
Koenig, L. N., Huber, H., Chongtham, A., Di Molfetta, G., Andrews, R. D., Lukic, A., Shafiian, N., Fillit, H. M., Blennow, K., Ashton, N. J., Zetterberg, H., Matthews, D. C., & Pereira, A. C. (2026). Plasma p-tau217 and glucose metabolism correlate in neocortical association areas in Alzheimer's disease. Brain communications, 8(2), fcag074. https://
BibTeX
@article{koenig2026plasm
author = {Koenig, Lauren N and Huber, Hanna and Chongtham, Anjalika and Di Molfetta, Guglielmo and Andrews, Randolph D and Lukic, Ana and Shafiian, Neeva and Fillit, Howard M and Blennow, Kaj and Ashton, Nicholas J and Zetterberg, Henrik and Matthews, Dawn C and Pereira, Ana C},
title = {{Plasma p-tau217 and glucose metabolism correlate in neocortical association areas in Alzheimer's disease}},
journal = {Brain communications},
year = {2026},
month = mar,
volume = {8},
number = {2},
pages = {fcag074},
publisher = {Oxford University Press},
issn = {2632-1297},
doi = {10.1093/
url = {https://
pmid = {41978790},
pmcid = {PMC13070614}
}
RIS
TY - JOUR
AU - Koenig, Lauren N
AU - Huber, Hanna
AU - Chongtham, Anjalika
AU - Di Molfetta, Guglielmo
AU - Andrews, Randolph D
AU - Lukic, Ana
AU - Shafiian, Neeva
AU - Fillit, Howard M
AU - Blennow, Kaj
AU - Ashton, Nicholas J
AU - Zetterberg, Henrik
AU - Matthews, Dawn C
AU - Pereira, Ana C
TI - Plasma p-tau217 and glucose metabolism correlate in neocortical association areas in Alzheimer's disease
T2 - Brain communications
J2 - Brain Commun
PY - 2026
DA - 2026/
VL - 8
IS - 2
SP - fcag074
SN - 2632-1297
PB - Oxford University Press
DO - 10.1093/
UR - https://
LA - en
ER -
CSL-JSON
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