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Identification and prioritisation of tumour antigen candidates from 79 glioblastoma transcriptomes.

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  1. [1] § Materials and methods › HLA typing, mutation detection ↔ src/FunctionalTester.py, lines 214–234 · score 0.61 · Mutation pipeline, reference genome, Variant Call, STAR, bam, VCF

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The authors' code

Python · 372 lines · 18 KB · BSD-3-Clause · 1 match

  2. __author__ = "Timothy Tickle"
  3. __copyright__ = "Copyright 2015"
  4. __credits__ = ["Timothy Tickle", "Brian Haas"]
  5. __license__ = "MIT"
  6. __maintainer__ = "Timothy Tickle"
  7. __email__ = "[email hidden]"
  8. __status__ = "Development"
  10. import Commandline
  11. import os
  12. import ParentPipelineTester
  13. import unittest
  15. class FunctionalTester(ParentPipelineTester.ParentPipelineTester):
  16. """
  17. Functional testing for scripts, these are focused on making sure the script can be called in different ways and complete without error.
  18. """
  20. # Testing environment
  21. str_script_dir = "/ahg/regev/users/ttickle/dev/Trinity_CTAT/mutation/src"
  22. str_test_data = "/seq/RNASEQ/public_ftp/CTAT/mutation/demo_data"
  23. str_testing_area = "/broad/hptmp/ttickle/active_testing_script_tester"
  24. os.environ['PATH'] = ":".join([str_script_dir,os.getenv('PATH',None)])
  26. str_input_index = os.path.join(str_test_data, "Hg19_11")
  27. str_input_test_bam = os.path.join(str_test_data, "Aligned.sortedByCoord.out.bam")
  28. str_left_file = os.path.join(str_test_data, "FLI1.left.fq")
  29. str_right_file = os.path.join(str_test_data, "FLI1.right.fq")
  30. str_reference_vcf = os.path.join(str_test_data, "dbsnp_FLI1.vcf")
  31. str_reference_genome = os.path.join(str_test_data, "Hg19_11.fa")
  32. str_update_command = "".join(["--update AddOrReplaceReadGroups.jar",
  33. ":/seq/regev_genome_portal/SOFTWARE/Picard/current,",
  34. "MarkDuplicates.jar",
  35. ":/seq/regev_genome_portal/SOFTWARE/Picard/current,",
  36. "SortSam.jar",
  37. ":/seq/regev_genome_portal/SOFTWARE/Picard/current,",
  38. "snpEff.jar",
  39. ":/seq/regev_genome_portal/SOFTWARE/snpEff,",
  40. "GenomeAnalysisTK.jar",
  41. ":/humgen/gsa-hpprojects/GATK/bin/GenomeAnalysisTK-3.1-1-g07a4bf8"])
  43. def test_rnaseq_mutation_pipeline_for_no_args(self):
  44. """
  45. Tests rnaseq_mutation_pipeline.py for no args call.
  46. """
  47. # Create test environment
  48. str_command = "python rnaseq_mutation_pipeline.py"
  49. # Run command
  50. f_success = Commandline.Commandline().func_CMD(str_command)
  51. # Test error
  52. self.assertFalse(f_success, str_command)
  54. def test_rnaseq_mutation_pipeline_for_args_short(self):
  55. """
  56. Tests rnaseq_mutation_pipeline.py for help args call short.
  57. """
  58. # Create test environment
  59. str_command = "python rnaseq_mutation_pipeline.py -h"
  60. # Run command
  61. f_success = Commandline.Commandline().func_CMD(str_command)
  62. # Test error
  63. self.assertTrue(f_success, str_command)
  65. def test_rnaseq_mutation_pipeline_for_args_long(self):
  66. """
  67. Tests rnaseq_mutation_pipeline.py for help args call short.
  68. """
  69. # Create test environment
  70. str_command = "python rnaseq_mutation_pipeline.py --help"
  71. # Run command
  72. f_success = Commandline.Commandline().func_CMD(str_command)
  73. # Test error
  74. self.assertTrue(f_success, str_command)
  76. def test_rnaseq_mutation_pipeline_for_test(self):
  77. """
  78. Tests rnaseq_mutation_pipeline.py for test mode.
  79. """
  80. # Create test environment
  81. str_command = " ".join(["python rnaseq_mutation_pipeline.py",
  82. "--alignment_mode STAR",
  83. "--variant_call_mode GATK",
  84. "--threads 8",
  85. "--plot",
  86. "--reference", self.str_reference_genome,
  87. "--left", self.str_left_file,
  88. "--right", self.str_right_file,
  89. "--test",
  90. "--out_dir", "_".join([self.str_testing_area,"vanilla_test"]),
  91. "--vcf",self.str_reference_vcf,
  92. self.str_update_command])
  93. # Run command
  94. f_success = Commandline.Commandline().func_CMD(str_command)
  95. # Test error
  96. self.assertTrue(f_success, str_command)
  98. def test_rnaseq_mutation_pipeline_for_gatk_call(self):
  99. """
  100. Tests rnaseq_mutation_pipeline.py for gatk call.
  101. """
  102. str_output_dir = os.path.join(self.str_testing_area,"vanilla_gatk")
  103. self.func_make_dummy_dirs([self.str_testing_area, str_output_dir])
  105. # Create test environment
  106. str_command = " ".join(["python rnaseq_mutation_pipeline.py",
  107. "--alignment_mode STAR",
  108. "--variant_call_mode GATK",
  109. "--threads 8",
  110. "--plot",
  111. "--reference", self.str_reference_genome,
  112. "--left", self.str_left_file,
  113. "--right", self.str_right_file,
  114. "--variant_filtering_mode GATK",
  115. "--out_dir",
  116. str_output_dir,
  117. "--vcf", self.str_reference_vcf,
  118. self.str_update_command])
  119. # Run command
  120. f_success = Commandline.Commandline().func_CMD(str_command)
  121. # Test error
  122. self.assertTrue(f_success, str_command)
  124. def test_rnaseq_mutation_pipeline_for_compression(self):
  125. """
  126. Tests rnaseq_mutation_pipeline.py for compression.
  127. """
  128. # Create test environment
  129. str_command = " ".join(["python rnaseq_mutation_pipeline.py",
  130. "--alignment_mode STAR",
  131. "--variant_call_mode GATK",
  132. "--threads 8",
  133. "--plot",
  134. "--reference", self.str_reference_genome,
  135. "--left", self.str_left_file,
  136. "--right",self.str_right_file,
  137. "--out_dir", "_".join([self.str_testing_area,"vanilla_compression"]),
  138. "--vcf", self.str_reference_vcf,
  139. self.str_update_command,
  140. "--compress","archive"])
  141. # Run command
  142. f_success = Commandline.Commandline().func_CMD(str_command)
  143. # Test error
  144. self.assertTrue(f_success, str_command)
  146. def test_rnaseq_mutation_pipeline_for_clean(self):
  147. """
  148. Tests rnaseq_mutation_pipeline.py for clean.
  149. """
  150. # Create test environment
  151. str_command = " ".join(["python rnaseq_mutation_pipeline.py",
  152. "--alignment_mode STAR",
  153. "--variant_call_mode GATK",
  154. "--threads 8",
  155. "--plot",
  156. "--reference", self.str_reference_genome,
  157. "--left", self.str_left_file,
  158. "--right", self.str_right_file,
  159. "--out_dir", "_".join([self.str_testing_area,"vanilla_clean"]),
  160. "--vcf", self.str_reference_vcf,
  161. self.str_update_command,
  162. "--clean"])
  163. # Run command
  164. f_success = Commandline.Commandline().func_CMD(str_command)
  165. # Test error
  166. self.assertTrue(f_success, str_command)
  168. def test_rnaseq_mutation_pipeline_for_archive(self):
  169. """
  170. Tests rnaseq_mutation_pipeline.py for archive.
  171. """
  172. # Create test environment
  173. str_copy_dir = os.path.join(self.str_testing_area, "copy_test_runs")
  174. str_command = " ".join(["python rnaseq_mutation_pipeline.py",
  175. "--alignment_mode STAR",
  176. "--variant_call_mode GATK",
  177. "--threads 8",
  178. "--plot",
  179. "--reference", self.str_reference_genome,
  180. "--left", self.str_left_file,
  181. "--right", self.str_right_file,
  182. "--out_dir", "_".join([self.str_testing_area,"vanilla_archive"]),
  183. "--vcf",self.str_reference_vcf, self.str_update_command,
  184. "--copy", str_copy_dir])
  185. # Run command
  186. if not os.path.exists(str_copy_dir):
  187. os.mkdir(str_copy_dir)
  188. f_success = Commandline.Commandline().func_CMD(str_command)
  189. # Test error
  190. self.assertTrue(f_success, str_command)
  192. def test_rnaseq_mutation_pipeline_for_realign(self):
  193. """
  194. Tests rnaseq_mutation_pipeline.py for realignment.
  195. """
  196. # Create test environment
  197. str_command = " ".join(["python rnaseq_mutation_pipeline.py",
  198. "--alignment_mode STAR",
  199. "--variant_call_mode GATK",
  200. "--threads 8",
  201. "--plot",
  202. "--reference", self.str_reference_genome,
  203. "--left", self.str_left_file,
  204. "--right", self.str_right_file,
  205. "--out_dir", "_".join([self.str_testing_area,"vanilla_realign"]),
  206. "--vcf", self.str_reference_vcf,
  207. self.str_update_command,
  208. "--realign"])
  209. # Run command
  210. f_success = Commandline.Commandline().func_CMD(str_command)
  211. # Test error
  212. self.assertTrue(f_success, str_command)
  214. def test_rnaseq_mutation_pipeline_for_starting_with_bam(self):
  215. """
  216. Tests rnaseq_mutation_pipeline.py for starting with a bam.
  217. """
  218. # Create test environment
  219. str_command = " ".join(["python rnaseq_mutation_pipeline.py",
  220. "--alignment_mode STAR",
  221. "--variant_call_mode GATK",
  222. "--threads 8",
  223. "--plot",
  224. "--reference", self.str_reference_genome,
  225. "--left", self.str_left_file,
  226. "--right",self.str_right_file,
  227. "--out_dir", "_".join([self.str_testing_area,"vanilla_bam"]),
  228. "--vcf", self.str_reference_vcf,
  229. self.str_update_command,
  230. "--bam", self.str_input_test_bam])
  231. # Run command
  232. f_success = Commandline.Commandline().func_CMD(str_command)
  233. # Test error
  234. self.assertTrue(f_success, str_command)
  236. def test_rnaseq_mutation_pipeline_for_star_limited(self):
  237. """
  238. Tests rnaseq_mutation_pipeline.py for starting with start limited mode
  239. """
  240. # Create test environment
  241. str_command = " ".join(["python rnaseq_mutation_pipeline.py",
  242. "--alignment_mode LIMITED",
  243. "--variant_call_mode GATK",
  244. "--threads 8",
  245. "--plot",
  246. "--reference", self.str_reference_genome,
  247. "--left", self.str_left_file,
  248. "--right", self.str_right_file,
  249. "--out_dir", "_".join([self.str_testing_area,"vanilla_limited"]),
  250. "--vcf", self.str_reference_vcf,
  251. self.str_update_command])
  252. # Run command
  253. f_success = Commandline.Commandline().func_CMD(str_command)
  254. # Test error
  255. self.assertTrue(f_success, str_command)
  257. def test_rnaseq_mutation_pipeline_for_named_log_file(self):
  258. """
  259. Tests rnaseq_mutation_pipeline.py for starting with a named log file.
  260. """
  261. # Create test environment
  262. str_command = " ".join(["python rnaseq_mutation_pipeline.py",
  263. "--alignment_mode STAR",
  264. "--variant_call_mode GATK",
  265. "--threads 8",
  266. "--plot",
  267. "--reference", self.str_reference_genome,
  268. "--left", self.str_left_file,
  269. "--right", self.str_right_file,
  270. "--out_dir", "_".join([self.str_testing_area,"vanilla_samtools"]),
  271. "--vcf", self.str_reference_vcf,
  272. self.str_update_command,
  273. "--log", os.path.join("_".join([self.str_testing_area,"vanilla_log"]),"run.log")])
  274. # Run command
  275. f_success = Commandline.Commandline().func_CMD(str_command)
  276. # Test error
  277. self.assertTrue(f_success, str_command)
  279. def test_rnaseq_mutation_pipeline_for_starting_with_premade_index(self):
  280. """
  281. Tests rnaseq_mutation_pipeline.py for starting with a premade index
  282. """
  283. # Create test environment
  284. str_command = " ".join(["python rnaseq_mutation_pipeline.py",
  285. "--alignment_mode STAR",
  286. "--variant_call_mode GATK",
  287. "--threads 8",
  288. "--plot",
  289. "--reference", self.str_reference_genome,
  290. "--left", self.str_left_file,
  291. "--right", self.str_right_file,
  292. "--out_dir", "_".join([self.str_testing_area,"vanilla_premade_index"]),
  293. "--vcf", self.str_reference_vcf,
  294. self.str_update_command,
  295. "--index", self.str_input_index])
  296. # Run command
  297. f_success = Commandline.Commandline().func_CMD(str_command)
  298. # Test error
  299. self.assertTrue(f_success, str_command)
  301. def test_rnaseq_mutation_pipeline_for_no_recalibration(self):
  302. """
  303. Tests rnaseq_mutation_pipeline.py for no recalibration
  304. """
  305. # Create test environment
  306. str_command = " ".join(["python rnaseq_mutation_pipeline.py",
  307. "--alignment_mode STAR",
  308. "--variant_call_mode GATK",
  309. "--threads 8",
  310. "--plot",
  311. "--reference", self.str_reference_genome,
  312. "--left", self.str_left_file,
  313. "--right", self.str_right_file,
  314. "--out_dir", "_".join([self.str_testing_area,"vanilla_no_recal"]),
  315. "--vcf", self.str_reference_vcf,
  316. self.str_update_command,
  317. "--recalibrate_sam"])
  318. # Run command
  319. f_success = Commandline.Commandline().func_CMD(str_command)
  320. # Test error
  321. self.assertTrue(f_success, str_command)
  323. def test_rnaseq_mutation_pipeline_for_move(self):
  324. """
  325. Tests rnaseq_mutation_pipeline.py for moving files
  326. """
  327. # Create test environment
  328. str_move_dir = os.path.join(self.str_testing_area, "move_test_runs")
  329. str_command = " ".join(["python rnaseq_mutation_pipeline.py",
  330. "--alignment_mode STAR",
  331. "--variant_call_mode GATK",
  332. "--threads 8",
  333. "--plot",
  334. "--reference", self.str_reference_genome,
  335. "--left", self.str_left_file,
  336. "--right", self.str_right_file,
  337. "--out_dir", "_".join([self.str_testing_area,"vanilla_no_move"]),
  338. "--vcf", self.str_reference_vcf,
  339. self.str_update_command,
  340. "--move", str_move_dir])
  341. # Run command
  342. if not os.path.exists(str_move_dir):
  343. os.mkdir(str_move_dir)
  344. f_success = Commandline.Commandline().func_CMD(str_command)
  345. # Test error
  346. self.assertTrue(f_success, str_command)
  348. def test_rnaseq_mutation_pipeline_for_no_filtering(self):
  349. """
  350. Tests rnaseq_mutation_pipeline.py for a run with no filtering.
  351. """
  352. # Create test environment
  353. str_command = " ".join(["python rnaseq_mutation_pipeline.py",
  354. "--alignment_mode STAR",
  355. "--variant_call_mode GATK",
  356. "--threads 8",
  357. "--plot",
  358. "--reference", self.str_reference_genome,
  359. "--left", self.str_left_file,
  360. "--right", self.str_right_file,
  361. "--variant_filtering_mode NONE",
  362. "--out_dir", "_".join([self.str_testing_area,"vanilla_samtools"]),
  363. "--vcf", self.str_reference_vcf,
  364. self.str_update_command])
  365. # Run command
  366. f_success = Commandline.Commandline().func_CMD(str_command)
  367. # Test error
  368. self.assertTrue(f_success, str_command)
  370. # Creates a suite of tests
  371. def suite():
  372. return unittest.TestLoader().loadTestsFromTestCase(FunctionalTester)

FunctionalTester.py at commit 42855af, under BSD-3-Clause · at the source

Overview

Authors: Špela Kert1, Jože Pižem1, Sara Petrin1, Matic Bošnjak1, Miha Jerala1, Alenka Matjašič1, Andrej Zupan1
ORCID iDs: Špela Kert, Jože Pižem, Sara Petrin, Matic Bošnjak, Miha Jerala, Alenka Matjašič, Andrej Zupan
  1. Faculty of Medicine, Institute of Pathology, University of Ljubljana,Ljubljana, Slovenia
Institutions: University of Ljubljana (Slovenia)
Journal: Cancer immunology, immunotherapy : CII, volume 75, issue 5, article 149
Dates: received 16 January 2026; accepted 6 April 2026; published online 21 April 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.1007/s00262-026-04390-3 · PMID 42012534 · PMCID PMC13100171 · OpenAlex W7155094685
Open access: gold, a free copy (OpenAlex)
Status: code verified
Categories: genetics / omics (modality), human (organism), other condition (population), cellular / molecular (subfield)
Methods: Statistics, Connectivity
Keywords: Glioblastoma, Tumor antigens, Computational immunology, HLA class I, Transcriptome sequencing
MeSH: Antigens, Neoplasm*, Brain Neoplasms*, Glioblastoma*, Transcriptome*, Biomarkers, Tumor, Gene Expression Profiling, Humans, Mutation (* major topic)
Topic: Glioma Diagnosis and Treatment (Genetics, Medicine), according to OpenAlex
Funding: Javna Agencija za Raziskovalno Dejavnost RS
Citations: not cited yet (Europe PMC); 49 references in the paper

Abstract

Glioblastoma (GBM) is an aggressive brain tumour with limited responsiveness to current immunotherapeutic approaches, partly due to its low mutational burden and intra-tumour heterogeneity. A systematic understanding of the tumour antigen landscape is therefore essential for advancing tumour immunology and supporting rational development of immunotherapeutic strategies. In this study, we performed whole-transcriptome sequencing of RNA extracted from 79 formalin-fixed paraffin-embedded (FFPE) IDH-wildtype GBM samples to systematically identify and prioritise candidate tumour antigens derived from three sources: single-nucleotide variants (SNVs), overexpressed tumour-associated antigens (TAAs), and gene fusion events. Candidate peptides were evaluated using integrated computational criteria, including transcript expression, predicted antigen processing features, peptide–HLA binding affinity and stability. Across the cohort, mutation-derived tumor-specific antigens (TSAs) were largely private to individual samples, whereas TAAs constituted a larger and more recurrent candidate pool. Despite comparable predicted binding characteristics across antigen classes, recurrence patterns differed substantially, reflecting their distinct biological origins. Fusion-derived candidates were rare and sample-specific. Predicted peptide presentation was disproportionately associated with a limited subset of HLA class I alleles. Collectively, this study provides a systematically prioritized catalogue of transcriptionally expressed GBM antigen candidates and offers a comparative evaluation of mutation-, expression-, and fusion-derived antigen sources within a unified transcriptome-based framework.

Supplementary Information: The online version contains supplementary material available at 10.1007/s00262-026-04390-3.

Reproduced under the paper's license (CC BY), from the paper cited above.

Repository

Its files are read in the Code ↔ Paper reader above, with 1 match between paragraphs and lines of code.

NCIP/ctat-mutations

License: BSD-3-Clause
State: the link answers, verified on 29 September 2026
Evidence: files inventoried
Commit: 42855afcc771db09819388ef71fb91f3a83a8415, 13 January 2026
Languages: Python (46), Shell (6), R (5), Perl (5)
Size: 172 files, 62 scripts
Software Heritage: not archived
Found in: the text, “HLA typing, mutation detection”
Holds: README, license file, environment (Docker/Dockerfile), tests
Not found: CITATION.cff, continuous integration, documentation
Tools: Matplotlib (6 files), pandas (6 files), NumPy (5 files), SAMtools (4 files), scikit-learn (3 files), BEDTools (2 files), pysam (2 files), SciPy (2 files), statsmodels (2 files), XGBoost (2 files), BCFtools (1 file), ggplot2 (1 file), reshape2 (1 file), tidyverse (1 file)
Availability: 1 check, the latest on 29 September 2026: the link answers
  • 29 September 2026: the link answers
64 files
At the source: github.com/NCIP/ctat-mutations

Tracing map

Proposed by the machine: these links were found in the paper and verified at the source, without human review. The map will receive a Zenodo DOI once one of the paper's authors has validated it with their ORCID.

What the map holds:

  • 1 repository of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
  • 62 scripts, each with its path and the digest of its content;
  • 1 match between paragraphs of the paper and lines of the code (method lexical-v1);
  • neither the text of the paper nor the code itself.

Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

No dataset and no data link were found in the paper.

Data availability

The data presented in this study are available on request from the corresponding author. The normal tissue dataset analysed in this study was obtained from: [https://www.gtexportal.org/home/downloads/adult-gtex/bulk_tissue_expression#bulk_tissue_expression-gtex_analysis_v10-rna-seq](https:/www.gtexportal.org/home/downloads/adult-gtex/bulk_tissue_expression), the Genotype-Tissue Expression (GTEx) Portal on 08/25/2025. The GTEx Project was supported by the Common Fund of the Office of the Director of the National Institutes of Health, and by NCI, NHGRI, NHLBI, NIDA, NIMH, and NINDS.

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 29 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 7 authors, 5 keywords, 8 MeSH terms, 1 funder, 48 references.

Cite

This paper

Kert, Š., Pižem, J., Petrin, S., Bošnjak, M., Jerala, M., Matjašič, A., & Zupan, A. (2026). Identification and prioritisation of tumour antigen candidates from 79 glioblastoma transcriptomes. Cancer immunology, immunotherapy : CII, 75(5), 149. https://doi.org/10.1007/s00262-026-04390-3

BibTeX

@article{kert2026identification,
author = {Kert, Špela and Pižem, Jože and Petrin, Sara and Bošnjak, Matic and Jerala, Miha and Matjašič, Alenka and Zupan, Andrej},
title = {{Identification and prioritisation of tumour antigen candidates from 79 glioblastoma transcriptomes}},
journal = {Cancer immunology, immunotherapy : CII},
year = {2026},
month = apr,
volume = {75},
number = {5},
pages = {149},
publisher = {Springer},
issn = {0340-7004},
doi = {10.1007/s00262-026-04390-3},
url = {https://doi.org/10.1007/s00262-026-04390-3},
pmid = {42012534},
pmcid = {PMC13100171}
}

RIS

TY - JOUR
AU - Kert, Špela
AU - Pižem, Jože
AU - Petrin, Sara
AU - Bošnjak, Matic
AU - Jerala, Miha
AU - Matjašič, Alenka
AU - Zupan, Andrej
TI - Identification and prioritisation of tumour antigen candidates from 79 glioblastoma transcriptomes
T2 - Cancer immunology, immunotherapy : CII
J2 - Cancer Immunol Immunother
PY - 2026
DA - 2026/04/21
VL - 75
IS - 5
SP - 149
SN - 0340-7004
PB - Springer
DO - 10.1007/s00262-026-04390-3
UR - https://doi.org/10.1007/s00262-026-04390-3
LA - en
ER -

CSL-JSON

{
"id": "10.1007/s00262-026-04390-3",
"type": "article-journal",
"title": "Identification and prioritisation of tumour antigen candidates from 79 glioblastoma transcriptomes",
"container-title": "Cancer immunology, immunotherapy : CII",
"author": [
{
"family": "Kert",
"given": "Špela"
},
{
"family": "Pižem",
"given": "Jože"
},
{
"family": "Petrin",
"given": "Sara"
},
{
"family": "Bošnjak",
"given": "Matic"
},
{
"family": "Jerala",
"given": "Miha"
},
{
"family": "Matjašič",
"given": "Alenka"
},
{
"family": "Zupan",
"given": "Andrej"
}
],
"container-title-short": "Cancer Immunol Immunother",
"volume": "75",
"issue": "5",
"page": "149",
"DOI": "10.1007/s00262-026-04390-3",
"PMID": "42012534",
"PMCID": "PMC13100171",
"ISSN": "0340-7004",
"publisher": "Springer",
"URL": "https://doi.org/10.1007/s00262-026-04390-3",
"language": "en",
"issued": {
"date-parts": [
[
2026,
4,
21
]
]
}
}

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