Mapping integrated care for brain tumour-related epilepsy in the Italian RIN-IRCCS network.
Overview
16 affiliations
- Neuro-Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta (FINCB), full member of the European Reference Network EURACAN,Milan, 20133 Italy
- Neurology, Public Health and Disability Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta,Milan, 20133 Italy
- Neuro-Oncology Unit, IRCCS Regina Elena National Cancer Institute,Rome, 00144 Italy
- Epilepsy Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, full member of the European Reference Network EpiCARE,Milan, 20133 Italy
- Neuro-Oncology Unit, IRCCS Istituto Giannina Gaslini,Genoa, 16147 Italy
- Neurology Unit, IRCCS Istituto delle Scienze Neurologiche di Bologna,Bologna, 40139 Italy
- Medical Oncology Unit 2, IRCCS Ospedale Policlinico San Martino,Genoa, 16132 Italy
- Hematology and Medical Oncology Unit, IRCCS Humanitas Research Hospital,Rozzano, 20089 Italy
- Neurooncology Unit, IRCCS Mondino Foundation,Pavia, 27100 Italy
- Neurology Unit, IRCCS Ospedale San Raffaele,Milan, 20132 Italy
- Neuro-Oncology Unit, Bambino Gesù Children’s Hospital, IRCCS,Rome, 00165 Italy
- Neuroimaging Research UnitNeurology UnitNeurorehabilitation Unit, and Neurophysiology Service, IRCCS Ospedale San Raffaele, Vita-Salute San Raffaele University,Milan, 20132 Italy
- Neurology, Epilepsy and Movement Disorders Unit, Bambino Gesù Children’s Hospital, IRCCS, Full Member of European Reference Network on Rare and Complex Epilepsies, EpiCARE,Rome, 00165 Italy
- IRCCS San Camillo Hospital,Venice, Italy
- Department of General Psychology, University of Padua,Padua, Italy
- Neurology Unit and Neurophysiology Service - IRCCS Ospedale San Raffaele,Milan, 20132 Italy
Abstract
Background: Brain tumour-related epilepsy is a frequent and disabling complication of primary and metastatic brain tumours, requiring multidimensional and coordinated management. However, specific guidelines and standardized care pathways for this condition are still lacking. This study aimed to assess the current organization of care for brain tumour-related epilepsy within the Italian Network of Neuroscience and Neuro-rehabilitation Research Institutes.
Methods: A national, multicentre survey was conducted across participating centres between April and June 2024, with follow-up validation in December 2025. The questionnaire investigated human resources, technological availability, clinical pathways, and management strategies. Data were analysed descriptively.
Results: Ten centres participated. All reported adopting a multidisciplinary approach, although with marked variability in team composition, expertise, and resources. Core specialists were available in most centres, while paediatric expertise was often lacking. Advanced neurophysiological monitoring and antiseizure medication level assessment were not uniformly accessible. Magnetic Resonance imaging was widely available, whereas Positron Emission Tomography was less consistently implemented. No centre had a dedicated clinical pathway for brain tumour–related epilepsy, despite the presence of pathways for brain tumours and epilepsy separately. Neuropsychological and comorbidity assessments were inconsistently integrated into care.
Conclusions: These findings highlight significant heterogeneity in the management of brain tumour-related epilepsy, even in highly specialized settings. The development of dedicated, standardized clinical pathways is needed to harmonize care and improve patient outcomes.
Supplementary Information: The online version contains supplementary material available at https://
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data
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- zenodo.org/
communities/ , at zenodo.org; found in “Data availability”besta - zenodo:15056694, at Zenodo; found in “Data availability”
Data availability
Data will be available at: https://
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 2, 28 September 2026
- Publisher: n/a → Springer Science+Business Media
Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 19 authors, 6 keywords, 6 MeSH terms, 1 funder, 20 references.
Cite
This paper
Anghileri, E., Marcassoli, A., Villani, V., Didato, G., Milanaccio, C., Pasini, E., Bennicelli, E., Persico, P., Bini, P., Berzero, G., Mastronuzzi, A., Filippi, M., De Palma, L., Arcara, G., Bellini, A., Maschio, M., Pace, A., Farinotti, M., & Silvani, A. (2026). Mapping integrated care for brain tumour-related epilepsy in the Italian RIN-IRCCS network. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 47(7), 589. https://
BibTeX
@article{anghileri2026ma
author = {Anghileri, Elena and Marcassoli, Alessia and Villani, Veronica and Didato, Giuseppe and Milanaccio, Claudia and Pasini, Elena and Bennicelli, Elisa and Persico, Pasquale and Bini, Paola and Berzero, Giulia and Mastronuzzi, Angela and Filippi, Massimo and De Palma, Luca and Arcara, Giorgio and Bellini, Anna and Maschio, Marta and Pace, Andrea and Farinotti, Mariangela and Silvani, Antonio},
title = {{Mapping integrated care for brain tumour-related epilepsy in the Italian RIN-IRCCS network}},
journal = {Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology},
year = {2026},
month = jun,
volume = {47},
number = {7},
pages = {589},
publisher = {Springer Science+Business Media},
issn = {1590-1874},
doi = {10.1007/
url = {https://
pmid = {42350833},
pmcid = {PMC13303563}
}
RIS
TY - JOUR
AU - Anghileri, Elena
AU - Marcassoli, Alessia
AU - Villani, Veronica
AU - Didato, Giuseppe
AU - Milanaccio, Claudia
AU - Pasini, Elena
AU - Bennicelli, Elisa
AU - Persico, Pasquale
AU - Bini, Paola
AU - Berzero, Giulia
AU - Mastronuzzi, Angela
AU - Filippi, Massimo
AU - De Palma, Luca
AU - Arcara, Giorgio
AU - Bellini, Anna
AU - Maschio, Marta
AU - Pace, Andrea
AU - Farinotti, Mariangela
AU - Silvani, Antonio
TI - Mapping integrated care for brain tumour-related epilepsy in the Italian RIN-IRCCS network
T2 - Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
J2 - Neurol Sci
PY - 2026
DA - 2026/
VL - 47
IS - 7
SP - 589
SN - 1590-1874
PB - Springer Science+Business Media
DO - 10.1007/
UR - https://
LA - en
ER -
CSL-JSON
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