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Exploration of miR-326 delivery via biocompatible polymeric nanoparticles in medulloblastoma: A preliminary study.

Overview

Authors: Elena Splendiani1, Gabriele Maiorano2,3, Zaira Spinello4, Davide Vecchiotti5, Giorgia Gugliuzza1, Marta Moretti1, Angela Asquino1, Mariapaola Izzo6, Agnese Po7, Nicole Feverati1, Tiziana Raia1, Zein Mersini Besharat1, Daniela Verzella5, Stefania Mardente1, Alessandra Zicari1, Giuseppe Ciccarella2,8,9, Anna Citarella4, Francesca Zazzeroni5, Enrico De Smaele1, Mary Anna Venneri1
and 6 other authorsAngela Mastronuzzi10, Giuseppe Gigli2,3,11, Adriano Angelucci5, Giuseppina Catanzaro4, Ilaria Elena Palamà2, Elisabetta Ferretti1
  1. Department of Experimental Medicine, La Sapienza University of Rome, 00161 Rome, Italy
  2. Nanotechnology Institute, CNR-NANOTEC, c/o Campus Ecotekne Monteroni Street, 73100 Lecce, Italy
  3. Tecnomed Puglia - Tecnopolo per la Medicina di Precisione (Biotech Lecce Hub), c/o Campus Ecotekne, Monteroni Street, Lecce, Italy
  4. Department of Life Sciences, Health and Health Professions, Link Campus University, Via del Casale di San Pio V, 44 00165 Rome, Italy
  5. Department of Biotechnological and Applied Clinical Sciences (DISCAB), University of L’Aquila, 67100 L’Aquila, Italy
  6. Department of Molecular Medicine, La Sapienza University of Rome, 00161 Rome, Italy
  7. Department of Radiological, Oncological & Pathological Sciences, La Sapienza University of Rome, 00161 Rome, Italy
  8. Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Via Monteroni, 73100 Lecce, Italy
  9. UdR INSTM, University of Salento, Lecce, Italy
  10. Department of Hematology/Oncology, Cell and Gene Therapy, Scientific Institute for Research, Hospitalization and Healthcare (IRCCS), Bambino Gesù Children’s Hospital, Rome, Italy
  11. Department of Experimental Medicine, University of Salento, c/o Campus Ecotekne, Monteroni Street, 73100 Lecce, Italy
Journal: Molecular therapy. Nucleic acids, volume 37, issue 2, article 102950
Dates: received 7 July 2025; accepted 6 May 2026; published online 9 May 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1016/j.omtn.2026.102950 · PMID 42233108 · PMCID PMC13223927 · OpenAlex W7160696907
Open access: gold, a free copy (OpenAlex)
Status: code on request
Categories: other condition (population), cellular / molecular (subfield)
Methods: Statistics
Keywords: MT: delivery strategies, nanoparticles, microRNA, medulloblastoma, polycaprolactone/chitosan, RNA delivery
Topic: Nanoparticle-Based Drug Delivery (Biomaterials, Materials Science), according to OpenAlex
Funding: Tecnopolo per la medicina di precisione; Hub Life Science (PNC-E3-2022-23683269); EU; PNC Italian Health Ministry; Piano di Sviluppo e Coesione del Ministero della Salute (2014-2020); Ministero dell'Università e della Ricerca (CN00000041 CN3 RNA); Ministero della Salute (Ministry of Health, Italy) (152/2021-PR;897/2025-PR)
Citations: not cited yet (Europe PMC); 41 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

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Code and data availability statement

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Read it in the paper: doi.org/10.1016/j.omtn.2026.102950.

Versions

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Version 2, 28 September 2026

  • Authors: added Elisabetta Ferretti (0000-0001-7265-6429); removed Elisabetta Ferretti

Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 26 authors, 6 keywords, 7 funders, 41 references.

Cite

This paper

Splendiani, E., Maiorano, G., Spinello, Z., Vecchiotti, D., Gugliuzza, G., Moretti, M., Asquino, A., Izzo, M., Po, A., Feverati, N., Raia, T., Besharat, Z. M., Verzella, D., Mardente, S., Zicari, A., Ciccarella, G., Citarella, A., Zazzeroni, F., De Smaele, E., . . . Ferretti, E. (2026). Exploration of miR-326 delivery via biocompatible polymeric nanoparticles in medulloblastoma: A preliminary study. Molecular therapy. Nucleic acids, 37(2), 102950. https://doi.org/10.1016/j.omtn.2026.102950

BibTeX

@article{splendiani2026exploration,
author = {Splendiani, Elena and Maiorano, Gabriele and Spinello, Zaira and Vecchiotti, Davide and Gugliuzza, Giorgia and Moretti, Marta and Asquino, Angela and Izzo, Mariapaola and Po, Agnese and Feverati, Nicole and Raia, Tiziana and Besharat, Zein Mersini and Verzella, Daniela and Mardente, Stefania and Zicari, Alessandra and Ciccarella, Giuseppe and Citarella, Anna and Zazzeroni, Francesca and De Smaele, Enrico and Venneri, Mary Anna and Mastronuzzi, Angela and Gigli, Giuseppe and Angelucci, Adriano and Catanzaro, Giuseppina and Palamà, Ilaria Elena and Ferretti, Elisabetta},
title = {{Exploration of miR-326 delivery via biocompatible polymeric nanoparticles in medulloblastoma: A preliminary study}},
journal = {Molecular therapy. Nucleic acids},
year = {2026},
month = may,
volume = {37},
number = {2},
pages = {102950},
publisher = {American Society of Gene \& Cell Therapy},
issn = {2162-2531},
doi = {10.1016/j.omtn.2026.102950},
url = {https://doi.org/10.1016/j.omtn.2026.102950},
pmid = {42233108},
pmcid = {PMC13223927}
}

RIS

TY - JOUR
AU - Splendiani, Elena
AU - Maiorano, Gabriele
AU - Spinello, Zaira
AU - Vecchiotti, Davide
AU - Gugliuzza, Giorgia
AU - Moretti, Marta
AU - Asquino, Angela
AU - Izzo, Mariapaola
AU - Po, Agnese
AU - Feverati, Nicole
AU - Raia, Tiziana
AU - Besharat, Zein Mersini
AU - Verzella, Daniela
AU - Mardente, Stefania
AU - Zicari, Alessandra
AU - Ciccarella, Giuseppe
AU - Citarella, Anna
AU - Zazzeroni, Francesca
AU - De Smaele, Enrico
AU - Venneri, Mary Anna
AU - Mastronuzzi, Angela
AU - Gigli, Giuseppe
AU - Angelucci, Adriano
AU - Catanzaro, Giuseppina
AU - Palamà, Ilaria Elena
AU - Ferretti, Elisabetta
TI - Exploration of miR-326 delivery via biocompatible polymeric nanoparticles in medulloblastoma: A preliminary study
T2 - Molecular therapy. Nucleic acids
J2 - Mol Ther Nucleic Acids
PY - 2026
DA - 2026/05/09
VL - 37
IS - 2
SP - 102950
SN - 2162-2531
PB - American Society of Gene & Cell Therapy
DO - 10.1016/j.omtn.2026.102950
UR - https://doi.org/10.1016/j.omtn.2026.102950
LA - en
ER -

CSL-JSON

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