OSCR

Multi-omics analysis and experimental validation reveal the IRF7-CXCL10 axis as a master regulator of microglial PCD in ischemic stroke.

Overview

Authors: Yongxing Lai1, Peiqiang Lin2, Kexin Zhang3, Wenyao Hong4, Mouwei Zheng1, Lijuan Wu1, Tin Chen2, Fan Lin1
  1. Department of Geriatric Medicine, Fuzhou University Affiliated Provincial Hospital,Fuzhou, 134 Dongjie Road, Fujian 350001 China
  2. Department of Neurology, Fuzhou University Affiliated Provincial Hospital,Fuzhou, China
  3. School of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology,Hebei, China
  4. Department of Neurosurgery, Fuzhou University Affiliated Provincial Hospital,Fuzhou, China
Institutions: Fuzhou University (China); Hebei University of Science and Technology (China)
Journal: Cell biology and toxicology, volume 42, issue 1, article 67
Dates: received 23 November 2025; accepted 23 March 2026; published online 6 April 2026; in print 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1007/s10565-026-10177-0 · PMID 41941036 · PMCID PMC13186846 · OpenAlex W7150812666
Open access: hybrid, a free copy (OpenAlex)
Status: data only
Categories: genetics / omics (modality), mouse (organism), stroke (population), cellular / molecular (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions, Machine learning, Spectral & time-frequency
Keywords: Programmed cell death, Single-cell, Ischemic stroke, IRF7, Neuroinflammation, Microglia
MeSH: Apoptosis*, Chemokine CXCL10*, Interferon Regulatory Factor-7*, Ischemic Stroke*, Microglia*, Animals, Coculture Techniques, Disease Models, Animal, Male, Mice, Mice, Inbred C57BL, Neurons (* major topic)
Topic: Neuroinflammation and Neurodegeneration Mechanisms (Neurology, Neuroscience), according to OpenAlex
Funding: Joint Funds for the Innovation of Science and Technology, Fujian province (No.2023Y9277, No.2024Y9602); Fujian Provincial Natural Science Foundation (No. 2023J05227)
Citations: cited by 1 paper (Europe PMC); 61 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Data links

Data availability statement

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  • it points to a dataset: NCBI

Read it in the paper: doi.org/10.1007/s10565-026-10177-0.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 29 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 8 authors, 6 keywords, 12 MeSH terms, 2 funders, 61 references.

Cite

This paper

Lai, Y., Lin, P., Zhang, K., Hong, W., Zheng, M., Wu, L., Chen, T., & Lin, F. (2026). Multi-omics analysis and experimental validation reveal the IRF7-CXCL10 axis as a master regulator of microglial PCD in ischemic stroke. Cell biology and toxicology, 42(1), 67. https://doi.org/10.1007/s10565-026-10177-0

BibTeX

@article{lai2026multi,
author = {Lai, Yongxing and Lin, Peiqiang and Zhang, Kexin and Hong, Wenyao and Zheng, Mouwei and Wu, Lijuan and Chen, Tin and Lin, Fan},
title = {{Multi-omics analysis and experimental validation reveal the IRF7-CXCL10 axis as a master regulator of microglial PCD in ischemic stroke}},
journal = {Cell biology and toxicology},
year = {2026},
month = apr,
volume = {42},
number = {1},
pages = {67},
publisher = {Springer Science+Business Media},
issn = {0742-2091},
doi = {10.1007/s10565-026-10177-0},
url = {https://doi.org/10.1007/s10565-026-10177-0},
pmid = {41941036},
pmcid = {PMC13186846}
}

RIS

TY - JOUR
AU - Lai, Yongxing
AU - Lin, Peiqiang
AU - Zhang, Kexin
AU - Hong, Wenyao
AU - Zheng, Mouwei
AU - Wu, Lijuan
AU - Chen, Tin
AU - Lin, Fan
TI - Multi-omics analysis and experimental validation reveal the IRF7-CXCL10 axis as a master regulator of microglial PCD in ischemic stroke
T2 - Cell biology and toxicology
J2 - Cell Biol Toxicol
PY - 2026
DA - 2026/04/06
VL - 42
IS - 1
SP - 67
SN - 0742-2091
PB - Springer Science+Business Media
DO - 10.1007/s10565-026-10177-0
UR - https://doi.org/10.1007/s10565-026-10177-0
LA - en
ER -

CSL-JSON

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"language": "en",
"issued": {
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}

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