Lack of cortistatin drives neuroimmune and vascular dysfunction in brain ischemia.
Overview
- Institute of Parasitology and Biomedicine (IPBLN-CSIC), Granada, Spain
- University of Lausanne, Lausanne, Switzerland
- Lausanne University Hospital, Lausanne, Switzerland
- Functional Genomics Center Zurich, ETH Zurich and University of Zurich, Zurich, Switzerland
- Swiss Institute of Bioinformatics, Amphipôle, Quartier UNIL-Sorge, Lausanne, Switzerland
Abstract
Background: Ischemic stroke remains a leading cause of death and disability, with limited therapies addressing its pathophysiology. Neuroinflammation, blood–brain barrier disruption, and immune dysregulation critically contribute to both acute neuronal injury and chronic functional decline. Elucidating the endogenous factors that govern these processes and understanding the intricate interplay among them is essential for developing effective therapeutic strategies. Cortistatin, a neuropeptide expressed in the nervous and immune systems, exhibits potent immunomodulatory actions, but its role in neuroinflammatory diseases remains unclear.
Methods: In this study, we combined human and murine transcriptomic analyses with a preclinical stroke model in cortistatin-deficient mice to investigate the endogenous and therapeutic roles of cortistatin during the acute (48 h) and subacute (7 days) phases of ischemic stroke.
Results: We demonstrate for the first time that cortistatin deficiency amplified ischemia-induced transcriptional programs, heightening neuroinflammation and glial/
Conclusions: These findings provide the first evidence identifying cortistatin as an endogenous neuroimmune regulator in ischemic stroke and a promising multimodal therapeutic agent for improving acute and long-term outcomes.
Supplementary Information: The online version contains supplementary material available at 10.1186/
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data
Datasets cited
- figshare:32747007, at figshare; found in DataCite
- figshare:32747010, at figshare; found in DataCite
- figshare:32747013, at figshare; found in DataCite
- figshare:32747016, at figshare; found in DataCite
- figshare:32747019, at figshare; found in DataCite
- figshare:32747022, at figshare; found in DataCite
- figshare:32747025, at figshare; found in DataCite
- figshare:32747028, at figshare; found in DataCite
- figshare:32747031, at figshare; found in DataCite
- figshare:32747034, at figshare; found in DataCite
- geo:GSE302342, at NCBI GEO; found in “Data availability”
Data availability
RNA-seq data are available in the GEO repository under accession number GSE302342 (https://
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 10 authors, 7 keywords, 10 MeSH terms, 6 funders, 111 references.
Cite
This paper
Castillo-González, J., Vargas-Rodríguez, P., Serrano-Martínez, I., Cuenca-Martagón, A., Forte-Lago, I., Price, M., Buscemi, L., Hirt, L., Ruiz, J. L., & González-Rey, E. (2026). Lack of cortistatin drives neuroimmune and vascular dysfunction in brain ischemia. Journal of biomedical science, 33(1), 65. https://
BibTeX
@article{castillogonzale
author = {Castillo-González, Julia and Vargas-Rodríguez, Pablo and Serrano-Martínez, Ignacio and Cuenca-Martagón, Alejandro and Forte-Lago, Irene and Price, Melanie and Buscemi, Lara and Hirt, Lorenz and Ruiz, José Luis and González-Rey, Elena},
title = {{Lack of cortistatin drives neuroimmune and vascular dysfunction in brain ischemia}},
journal = {Journal of biomedical science},
year = {2026},
month = jun,
volume = {33},
number = {1},
pages = {65},
publisher = {BMC},
issn = {1021-7770},
doi = {10.1186/
url = {https://
pmid = {42321803},
pmcid = {PMC13282875}
}
RIS
TY - JOUR
AU - Castillo-González, Julia
AU - Vargas-Rodríguez, Pablo
AU - Serrano-Martínez, Ignacio
AU - Cuenca-Martagón, Alejandro
AU - Forte-Lago, Irene
AU - Price, Melanie
AU - Buscemi, Lara
AU - Hirt, Lorenz
AU - Ruiz, José Luis
AU - González-Rey, Elena
TI - Lack of cortistatin drives neuroimmune and vascular dysfunction in brain ischemia
T2 - Journal of biomedical science
J2 - J Biomed Sci
PY - 2026
DA - 2026/
VL - 33
IS - 1
SP - 65
SN - 1021-7770
PB - BMC
DO - 10.1186/
UR - https://
LA - en
ER -
CSL-JSON
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