OSCR

PYGL-driven glycogenolysis impairs microglial autophagic flux <i>via</i> SNAP29 <i>O</i>-GlcNAcylation in Alzheimer's disease.

Overview

Authors: Yi Ding1, Shi-Yao Li1, Wen-Feng Zhang1, Mao-Mao Chu1, Xue-Jie Wang1, Yu-Ge Zhang1, Hui-Wen Zhang1, Yu-Tong Zhang1, Lu Xu1, Xue Liu1, Tsuyoshi Morita2, Otto Baba2, Zi-Jian Ren3,4, Yong-Jie Zhang3,4, Zhi-Yuan Zhang1,5,6, Lei Li1
ORCID iDs: Zhi-Yuan Zhang, Lei Li
  1. School of Basic Medical Sciences, Nanjing Medical University, Nanjing 211166, China
  2. Oral and Maxillofacial Anatomy, Tokushima University Graduate School, Tokushima 770-8504, Japan
  3. Department of Human Anatomy, Nanjing Medical University, Nanjing 211166, China
  4. Human Brain Tissue Resource Center, Nanjing Medical University, Nanjing 211166, China
  5. Jiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing 211166, China
  6. Department of Neurology, Sir Run Run Hospital, Nanjing Medical University, Nanjing 211112, China
Institutions: Nanjing Medical University (China); Tokushima University (Japan)
Journal: Acta pharmaceutica Sinica. B, volume 16, issue 7, pages 4367-4388
Dates: received 2 September 2025; accepted 17 February 2026; published online 27 April 2026; in print July 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1016/j.apsb.2026.04.017 · PMID 42453424 · PMCID PMC13366299 · OpenAlex W7156160089
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: Alzheimer's / dementia (population), cellular / molecular (subfield)
Methods: Spectral & time-frequency, Statistics, Smoothing, state filtering, decompositions, Connectivity
Keywords: Glycogen metabolism, Glycogenolysis, PYGL, O-GlcNAcylation, SNARE complex, SNAP29, Autophagosome–lysosome fusion, Autophagy
Topic: Glycosylation and Glycoproteins Research (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: National Natural Science Foundation of China (82471218, 82401689); Graduate Research and Innovation Projects of Jiangsu Province (JX10114228)
Citations: not cited yet (Europe PMC); 67 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

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Data

Datasets cited

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 16 authors, 8 keywords, 2 funders, 67 references.

Cite

This paper

Ding, Y., Li, S.-Y., Zhang, W.-F., Chu, M.-M., Wang, X.-J., Zhang, Y.-G., Zhang, H.-W., Zhang, Y.-T., Xu, L., Liu, X., Morita, T., Baba, O., Ren, Z.-J., Zhang, Y.-J., Zhang, Z.-Y., & Li, L. (2026). PYGL-driven glycogenolysis impairs microglial autophagic flux <i>via</i> SNAP29 <i>O</i>-GlcNAcylation in Alzheimer's disease. Acta pharmaceutica Sinica. B, 16(7), 4367-4388. https://doi.org/10.1016/j.apsb.2026.04.017

BibTeX

@article{ding2026pygl,
author = {Ding, Yi and Li, Shi-Yao and Zhang, Wen-Feng and Chu, Mao-Mao and Wang, Xue-Jie and Zhang, Yu-Ge and Zhang, Hui-Wen and Zhang, Yu-Tong and Xu, Lu and Liu, Xue and Morita, Tsuyoshi and Baba, Otto and Ren, Zi-Jian and Zhang, Yong-Jie and Zhang, Zhi-Yuan and Li, Lei},
title = {{PYGL-driven glycogenolysis impairs microglial autophagic flux \<i\>via\</i\> SNAP29 \<i\>O\</i\>-GlcNAcylation in Alzheimer's disease}},
journal = {Acta pharmaceutica Sinica. B},
year = {2026},
month = apr,
volume = {16},
number = {7},
pages = {4367--4388},
publisher = {Elsevier},
issn = {2211-3835},
doi = {10.1016/j.apsb.2026.04.017},
url = {https://doi.org/10.1016/j.apsb.2026.04.017},
pmid = {42453424},
pmcid = {PMC13366299}
}

RIS

TY - JOUR
AU - Ding, Yi
AU - Li, Shi-Yao
AU - Zhang, Wen-Feng
AU - Chu, Mao-Mao
AU - Wang, Xue-Jie
AU - Zhang, Yu-Ge
AU - Zhang, Hui-Wen
AU - Zhang, Yu-Tong
AU - Xu, Lu
AU - Liu, Xue
AU - Morita, Tsuyoshi
AU - Baba, Otto
AU - Ren, Zi-Jian
AU - Zhang, Yong-Jie
AU - Zhang, Zhi-Yuan
AU - Li, Lei
TI - PYGL-driven glycogenolysis impairs microglial autophagic flux <i>via</i> SNAP29 <i>O</i>-GlcNAcylation in Alzheimer's disease
T2 - Acta pharmaceutica Sinica. B
J2 - Acta Pharm Sin B
PY - 2026
DA - 2026/04/27
VL - 16
IS - 7
SP - 4367
EP - 4388
SN - 2211-3835
PB - Elsevier
DO - 10.1016/j.apsb.2026.04.017
UR - https://doi.org/10.1016/j.apsb.2026.04.017
LA - en
ER -

CSL-JSON

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