OSCR

Neutrophil-mediated BDNF delivery for the treatment of moderate to severe Alzheimer's disease.

Overview

Authors: Feng Qin1,2, Ni Zhang3, Yanjiao Jiang4, Kunyao Xu4, Yang Xiong2, Yuhang Liu2, Qiuhong Ouyang1, Haxiaoyu Liu1, Yanping Dai1, Linhong Jiang1, Yue Zhao1, Hongchun Li1, Liang Wang1, Yaxing Chen1, Liqiang Hu5, Qian Bu1, Yinglan Zhao1, Weihong Kuang3, Meng Qin1, Xiaobo Cen1
ORCID iDs: Meng Qin, Xiaobo Cen
  1. Mental Health Center, National Center for Mental Disorders, and Center for Preclinical Safety Evaluation of Drugs, State Key Lab of Biotherapy, West China Hospital, Sichuan University, Chengdu 610000, China
  2. Andrology Laboratory, West China Hospital, Sichuan University, Chengdu 610000, China
  3. Mental Health Center, National Center for Mental Disorders, West China Hospital, Sichuan University, Chengdu 610000, China
  4. College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100000, China
  5. West China-California Research Center for Predictive Intervention Medicine, State Key Lab of Biotherapy, West China Hospital, Sichuan University, Chengdu 610000, China
Institutions: Sichuan University (China); West China Hospital of Sichuan University (China); State Key Laboratory of Biotherapy; West China Medical Center of Sichuan University (China); Beijing University of Chemical Technology (China)
Journal: Acta pharmaceutica Sinica. B, volume 16, issue 9, pages 6185-6202
Dates: received 7 November 2025; accepted 6 July 2026; published online 10 July 2026; in print September 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1016/j.apsb.2026.07.009 · PMID 42764861 · PMCID PMC13589925 · OpenAlex W7167904675
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: mouse (organism), Alzheimer's / dementia (population)
Methods: Statistics, Smoothing, state filtering, decompositions, Machine learning, Preprocessing
Keywords: Alzheimer’s disease, Brain-derived neurotrophic factor, Neutrophil, Blood–brain barrier, Amyloid-β, Neuroinflammation, Hippocampus, Learning and memory abilities
Topic: Alzheimer's disease research and treatments (Physiology, Medicine), according to OpenAlex
Funding: National Natural Science Foundation of China (82371498, 82071494, 52473137); Sichuan Province Science and Technology Support Program (2026YFHZ0068); West China Hospital, Sichuan University (ZYGD23011, ZYJC21029)
Citations: not cited yet (Europe PMC); 55 references in the paper
Research resources: human neuroblastoma cells RRID:CVCL_0019, RRID:CVCL_0170, Human induced pluripotent stem cells RRID:CVCL_A4EF

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper links to its data, not to its authors' code: see the Data section.

Tracing map

A tracing map links a paper to the code its authors published: this paper has none, so it has no map.

Data

Datasets cited

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 2, 28 September 2026

  • Authors: added Meng Qin (0000-0002-5448-2477); Xiaobo Cen (0000-0002-9760-5238); removed Meng Qin; Xiaobo Cen
  • Funding: added National Natural Science Foundation of China: 82371498, 82071494, 52473137; Sichuan Province Science and Technology Support Program: 2026YFHZ0068; West China Hospital, Sichuan University: ZYGD23011, ZYJC21029

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 20 authors, 8 keywords, 54 references, 3 RRIDs.

Cite

This paper

Qin, F., Zhang, N., Jiang, Y., Xu, K., Xiong, Y., Liu, Y., Ouyang, Q., Liu, H., Dai, Y., Jiang, L., Zhao, Y., Li, H., Wang, L., Chen, Y., Hu, L., Bu, Q., Zhao, Y., Kuang, W., Qin, M., & Cen, X. (2026). Neutrophil-mediated BDNF delivery for the treatment of moderate to severe Alzheimer's disease. Acta pharmaceutica Sinica. B, 16(9), 6185-6202. https://doi.org/10.1016/j.apsb.2026.07.009

BibTeX

@article{qin2026neutrophil,
author = {Qin, Feng and Zhang, Ni and Jiang, Yanjiao and Xu, Kunyao and Xiong, Yang and Liu, Yuhang and Ouyang, Qiuhong and Liu, Haxiaoyu and Dai, Yanping and Jiang, Linhong and Zhao, Yue and Li, Hongchun and Wang, Liang and Chen, Yaxing and Hu, Liqiang and Bu, Qian and Zhao, Yinglan and Kuang, Weihong and Qin, Meng and Cen, Xiaobo},
title = {{Neutrophil-mediated BDNF delivery for the treatment of moderate to severe Alzheimer's disease}},
journal = {Acta pharmaceutica Sinica. B},
year = {2026},
month = jul,
volume = {16},
number = {9},
pages = {6185--6202},
publisher = {Elsevier},
issn = {2211-3835},
doi = {10.1016/j.apsb.2026.07.009},
url = {https://doi.org/10.1016/j.apsb.2026.07.009},
pmid = {42764861},
pmcid = {PMC13589925}
}

RIS

TY - JOUR
AU - Qin, Feng
AU - Zhang, Ni
AU - Jiang, Yanjiao
AU - Xu, Kunyao
AU - Xiong, Yang
AU - Liu, Yuhang
AU - Ouyang, Qiuhong
AU - Liu, Haxiaoyu
AU - Dai, Yanping
AU - Jiang, Linhong
AU - Zhao, Yue
AU - Li, Hongchun
AU - Wang, Liang
AU - Chen, Yaxing
AU - Hu, Liqiang
AU - Bu, Qian
AU - Zhao, Yinglan
AU - Kuang, Weihong
AU - Qin, Meng
AU - Cen, Xiaobo
TI - Neutrophil-mediated BDNF delivery for the treatment of moderate to severe Alzheimer's disease
T2 - Acta pharmaceutica Sinica. B
J2 - Acta Pharm Sin B
PY - 2026
DA - 2026/07/10
VL - 16
IS - 9
SP - 6185
EP - 6202
SN - 2211-3835
PB - Elsevier
DO - 10.1016/j.apsb.2026.07.009
UR - https://doi.org/10.1016/j.apsb.2026.07.009
LA - en
ER -

CSL-JSON

{
"id": "10.1016/j.apsb.2026.07.009",
"type": "article-journal",
"title": "Neutrophil-mediated BDNF delivery for the treatment of moderate to severe Alzheimer's disease",
"container-title": "Acta pharmaceutica Sinica. B",
"author": [
{
"family": "Qin",
"given": "Feng"
},
{
"family": "Zhang",
"given": "Ni"
},
{
"family": "Jiang",
"given": "Yanjiao"
},
{
"family": "Xu",
"given": "Kunyao"
},
{
"family": "Xiong",
"given": "Yang"
},
{
"family": "Liu",
"given": "Yuhang"
},
{
"family": "Ouyang",
"given": "Qiuhong"
},
{
"family": "Liu",
"given": "Haxiaoyu"
},
{
"family": "Dai",
"given": "Yanping"
},
{
"family": "Jiang",
"given": "Linhong"
},
{
"family": "Zhao",
"given": "Yue"
},
{
"family": "Li",
"given": "Hongchun"
},
{
"family": "Wang",
"given": "Liang"
},
{
"family": "Chen",
"given": "Yaxing"
},
{
"family": "Hu",
"given": "Liqiang"
},
{
"family": "Bu",
"given": "Qian"
},
{
"family": "Zhao",
"given": "Yinglan"
},
{
"family": "Kuang",
"given": "Weihong"
},
{
"family": "Qin",
"given": "Meng"
},
{
"family": "Cen",
"given": "Xiaobo"
}
],
"container-title-short": "Acta Pharm Sin B",
"volume": "16",
"issue": "9",
"page": "6185-6202",
"DOI": "10.1016/j.apsb.2026.07.009",
"PMID": "42764861",
"PMCID": "PMC13589925",
"ISSN": "2211-3835",
"publisher": "Elsevier",
"URL": "https://doi.org/10.1016/j.apsb.2026.07.009",
"language": "en",
"issued": {
"date-parts": [
[
2026,
7,
10
]
]
}
}

Similar papers

The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.

[1] doi:10.1111/acel.70646
HNRNPC Succinylation Influences the Neurodegeneration of Alzheimer's Disease Through YME1L1-Mediated Mitochondrial Metabolism.
Journal: Aging cell
In common: NCBI GEO GSE48350, Alzheimer's / dementia, mouse
[2] doi:10.1186/s13195-026-02075-8
Physical exercise in combination with audiovisual stimulation alleviates cognitive and affective impairments in Alzheimer's disease model mice via restoring lysosomal membrane integrity.
Journal: Alzheimer's research & therapy
In common: Alzheimer's / dementia, mouse, 3 references
[3] doi:10.1038/s41467-026-76725-8
TogoPhosTAC as a delivery-ready platform for targeted protein dephosphorylation.
Journal: Nature communications
In common: Alzheimer's / dementia, mouse, 2 references
[4] doi:10.1038/s41380-026-03592-6
Pyrazole-derived TRPC3 antagonist ameliorates synaptic dysfunctions and memory deficits in Alzheimer's disease models.
Journal: Molecular psychiatry
In common: Alzheimer's / dementia, mouse, 2 references
[5] doi:10.3390/ijms27114756
Multi-Omics Integration and Causal Inference Identify HSD17B1 as a Potential Nobiletin Target Linking Neurosteroid Metabolism to Alzheimer's Disease.
Journal: International journal of molecular sciences
In common: Alzheimer's / dementia, 3 references
[6] doi:10.1007/s00401-026-03033-2
AETA peptide contributes to Alzheimer's disease signature of synapse dysfunction.
Journal: Acta neuropathologica
In common: Alzheimer's / dementia, mouse, 2 references
[7] doi:10.1186/s13195-026-02030-7
Moderating role of executive function in the relationship between specific white matter changes and long-term delayed recall in aMCI patients.
Journal: Alzheimer's research & therapy
In common: Alzheimer's / dementia, 2 references
[8] doi:10.34133/csbj.0134 [code]
Integrated Multi-Tissue Transcriptomics Reveals Antagonistic Pleiotropy in Aging and Alzheimer's Disease.
Journal: Computational and structural biotechnology journal
In common: Alzheimer's / dementia, 2 references
[9] doi:10.1038/s41380-026-03656-7
Sex-specific regulation of angiogenin in Alzheimer's disease.
Journal: Molecular psychiatry
In common: Alzheimer's / dementia, mouse, 2 references
[10] doi:10.3390/biology15110818
Triptolide Reduces Cholesterol Synthesis and Alleviates Neuroinflammation by Inhibiting CD33 in Alzheimer's Disease Development and Progression.
Journal: Biology
In common: Alzheimer's / dementia, mouse, 2 references

Contribute

The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.

Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.

Request its removal

To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).

Discussion, reproductions, activity

Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.

Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.

Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.