OSCR

TogoPhosTAC as a delivery-ready platform for targeted protein dephosphorylation.

Overview

Authors: Yu-Yu Chen1,2, Dong-Ting Ke1, Yen-Chun Lee2, Hong-Ru Chen3,4, Hsiang-Ying Lin3,4, Chun-Hsin Yeh1, Yu-Ching Ko1, Meng-Han Tu1, Chien-Hung Yu1,5, Zhenyi Hu6, Po-Han Chen1,5
ORCID iDs: Yu-Yu Chen, Hong-Ru Chen, Chun-Hsin Yeh, Po-Han Chen
  1. Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan
  2. Department of Chemistry, College of Science, National Cheng Kung University, Tainan, Taiwan
  3. Department of Life Sciences and Institute of Genome Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan
  4. Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan
  5. Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan
  6. Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China
Institutions: National Cheng Kung University (Taiwan); National Yang Ming Chiao Tung University (Taiwan); Chinese Academy of Sciences (China); Shanghai Institute of Organic Chemistry (China)
Journal: Nature communications, volume 17, issue 1, article 9772
Dates: received 14 March 2025; accepted 28 July 2026; published online 14 August 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41467-026-76725-8 · PMID 42733006 · PMCID PMC13572435 · OpenAlex W7203439800
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: human (organism), mouse (organism), Alzheimer's / dementia (population), Parkinson's (population), cellular / molecular (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions
Keywords: Phosphorylation, Animal disease models, Phosphoproteins, Drug delivery, Protein design
MeSH: Phosphoric Monoester Hydrolases*, Phosphorylation*, alpha-Synuclein, Alzheimer Disease, Animals, ErbB Receptors, Humans, Male, Mice, Mice, Transgenic, Nanoparticles, Tacrolimus Binding Protein 1A, tau Proteins (* major topic)
Topic: Protein Degradation and Inhibitors (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: Ministry of Science and Technology, Taiwan (Ministry of Science and Technology of Taiwan) (114-2320-B-006-027-MY3, 114-2628-B-006-014, 113-2628-B-006-004); National Health Research Institutes (NHRI) (EX114-11308BC, EX113-11308BC, EX115-11308BC)
Citations: not cited yet (Europe PMC); 126 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • no repository, dataset or request procedure was recognized in it

Read it in the paper: doi.org/10.1038/s41467-026-76725-8.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 11 authors, 5 keywords, 13 MeSH terms, 2 funders, 124 references.

Cite

This paper

Chen, Y.-Y., Ke, D.-T., Lee, Y.-C., Chen, H.-R., Lin, H.-Y., Yeh, C.-H., Ko, Y.-C., Tu, M.-H., Yu, C.-H., Hu, Z., & Chen, P.-H. (2026). TogoPhosTAC as a delivery-ready platform for targeted protein dephosphorylation. Nature communications, 17(1), 9772. https://doi.org/10.1038/s41467-026-76725-8

BibTeX

@article{chen2026togophostac,
author = {Chen, Yu-Yu and Ke, Dong-Ting and Lee, Yen-Chun and Chen, Hong-Ru and Lin, Hsiang-Ying and Yeh, Chun-Hsin and Ko, Yu-Ching and Tu, Meng-Han and Yu, Chien-Hung and Hu, Zhenyi and Chen, Po-Han},
title = {{TogoPhosTAC as a delivery-ready platform for targeted protein dephosphorylation}},
journal = {Nature communications},
year = {2026},
month = aug,
volume = {17},
number = {1},
pages = {9772},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-76725-8},
url = {https://doi.org/10.1038/s41467-026-76725-8},
pmid = {42733006},
pmcid = {PMC13572435}
}

RIS

TY - JOUR
AU - Chen, Yu-Yu
AU - Ke, Dong-Ting
AU - Lee, Yen-Chun
AU - Chen, Hong-Ru
AU - Lin, Hsiang-Ying
AU - Yeh, Chun-Hsin
AU - Ko, Yu-Ching
AU - Tu, Meng-Han
AU - Yu, Chien-Hung
AU - Hu, Zhenyi
AU - Chen, Po-Han
TI - TogoPhosTAC as a delivery-ready platform for targeted protein dephosphorylation
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/08/14
VL - 17
IS - 1
SP - 9772
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-76725-8
UR - https://doi.org/10.1038/s41467-026-76725-8
LA - en
ER -

CSL-JSON

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