Physical exercise in combination with audiovisual stimulation alleviates cognitive and affective impairments in Alzheimer's disease model mice via restoring lysosomal membrane integrity.
Overview
- Department of Neurology, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, Zhejiang 315040 China
- Department of Physiology and Pathophysiology, Health Science Center, Ningbo University, Ningbo, Zhejiang 315211 China
- Faculty of Sports Science, Ningbo University, Ningbo, Zhejiang 315211 China
- Department of Anesthesiology, Women and Children’s Hospital, Ningbo University, Ningbo, Zhejiang 315012 China
- Department of Geriatrics, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang 315010 China
- China Institute of Sport Science, Beijing, 100061 China
Abstract
Background: Alzheimer’s disease (AD) is a progressive disorder characterized by cognitive decline. Physical exercise and audiovisual stimulation have gained increasing concern for their potential to mitigate AD pathology. However, the therapeutic advantages of combining these interventions and the precise molecular mechanisms underlying these strategies need further demonstration.
Objectives: This study aimed to assess the protective effects and underlying mechanisms of physical exercise combined with audiovisual stimulation on cognitive and affective functions, as well as on pathological alterations in AD mice.
Methods: Both AD model mice established by injecting Aβ₄₂ oligomers into hippocampus and APP/
Results: The multimodal intervention significantly prevented cognitive impairment and ameliorated anxiety/
Conclusion: Physical exercise and audiovisual stimulation exert synergistic effects in decreasing the inflammation reaction and maintaining autophagy-lysosomal homeostasis by increasing the biogenesis of lysosomes and restoring the integrity of lysosome membrane, thereby reducing Aβ deposition and cognitive defect of AD mice. This study highlights the significant therapeutic potential of multimodal, non-pharmacological strategies for Alzheimer’s disease.
Supplementary Information: The online version contains supplementary material available at 10.1186/
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data
Datasets cited
- figshare:33128259, at figshare; found in DataCite
Data availability
The raw data have been uploaded to iProX and are publicly available at https://
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 1, 28 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 13 authors, 6 keywords, 16 MeSH terms, 7 funders, 61 references.
Cite
This paper
Jia, J., Xie, G., Zheng, W., Xu, C., Xia, Y., Hu, Q., Xiang, B., Zhou, X., Chen, A., Chen, X., Wang, Q., Zhou, Y., & Xu, S. (2026). Physical exercise in combination with audiovisual stimulation alleviates cognitive and affective impairments in Alzheimer's disease model mice via restoring lysosomal membrane integrity. Alzheimer's research & therapy, 18(1), 178. https://
BibTeX
@article{jia2026physical
author = {Jia, Jun and Xie, Guomin and Zheng, Wu and Xu, Chunshuang and Xia, Yuxin and Hu, Qiaoxia and Xiang, Binbin and Zhou, Xinkai and Chen, Anqi and Chen, Xiaoping and Wang, Qinwen and Zhou, Yingsong and Xu, Shujun},
title = {{Physical exercise in combination with audiovisual stimulation alleviates cognitive and affective impairments in Alzheimer's disease model mice via restoring lysosomal membrane integrity}},
journal = {Alzheimer's research \& therapy},
year = {2026},
month = may,
volume = {18},
number = {1},
pages = {178},
publisher = {BMC},
issn = {1758-9193},
doi = {10.1186/
url = {https://
pmid = {42216028},
pmcid = {PMC13425872}
}
RIS
TY - JOUR
AU - Jia, Jun
AU - Xie, Guomin
AU - Zheng, Wu
AU - Xu, Chunshuang
AU - Xia, Yuxin
AU - Hu, Qiaoxia
AU - Xiang, Binbin
AU - Zhou, Xinkai
AU - Chen, Anqi
AU - Chen, Xiaoping
AU - Wang, Qinwen
AU - Zhou, Yingsong
AU - Xu, Shujun
TI - Physical exercise in combination with audiovisual stimulation alleviates cognitive and affective impairments in Alzheimer's disease model mice via restoring lysosomal membrane integrity
T2 - Alzheimer's research & therapy
J2 - Alzheimers Res Ther
PY - 2026
DA - 2026/
VL - 18
IS - 1
SP - 178
SN - 1758-9193
PB - BMC
DO - 10.1186/
UR - https://
LA - en
ER -
CSL-JSON
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