OSCR

Ether phospholipids modulate somatosensory responses by tuning multiple receptor functions in <i>Drosophila</i>.

Overview

Authors: Takuto Suito1,2, Xiangmei Deng1,2, Shoma Sato1,2, Kohjiro Nagao3, Christian Ganser2, Takayuki Uchihashi2,4, Motosuke Tsutsumi2,5, Tomomi Nemoto2,5,6, Yuji Hara7, Makoto Tominaga8, Takaaki Sokabe1,2,6
ORCID iDs: Kohjiro Nagao
  1. Section of Sensory Physiology, Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Japan
  2. Exploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences, Okazaki, Japan
  3. Department of Biophysical Chemistry, Kyoto Pharmaceutical University, Kyoto, Japan
  4. Department of Physics, Nagoya University, Nagoya, Japan
  5. Division of Biophotonics, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Japan
  6. Graduate Institute for Advanced Studies, SOKENDAI, Hayama, Japan
  7. School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
  8. Nagoya Advanced Research and Development Center, Nagoya City University, Nagoya, Japan
Institutions: National Institutes of Natural Sciences (Japan); National Institute for Physiological Sciences (Japan); The Exploratory Research Center on Life and Living Systems (Japan); Kyoto Pharmaceutical University (Japan); Nagoya University (Japan); The Graduate University for Advanced Studies, SOKENDAI (Japan); Shizuoka University (Japan); University of Shizuoka (Japan); Nagoya City University (Japan)
Journal: iScience, volume 29, issue 4, article 115209
Dates: received 29 August 2025; accepted 26 February 2026; published online 3 March 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.1016/j.isci.2026.115209 · PMID 41907445 · PMCID PMC13018890 · OpenAlex W7133359689
Open access: gold, a free copy (OpenAlex)
Status: code on request
Categories: drosophila (organism), cellular / molecular (subfield)
Methods: Statistics, Evoked potentials, Single-unit activity, calcium imaging
Keywords: Mechanobiology, cell biology, model organism
Topic: Neurobiology and Insect Physiology Research (Cellular and Molecular Neuroscience, Neuroscience), according to OpenAlex
Funding: Japan Agency for Medical Research and Development (23gm6510014h0002); Japan Society for the Promotion of Science (21K15192, 19K23790, 21H02531, JP22H04926); RIKEN; Shizuoka University; Ministry of Education, Culture, Sports, Science and Technology
Citations: not cited yet (Europe PMC); 91 references in the paper
Research resources: α-GFP primary antibody RRID:AB_221570, α-Rabbit IgG-Alexa488 RRID:AB_2576217, α-Mouse-CD8a antibody RRID:AB_312751, pU6-BbsI-chiRNA vector RRID:Addgene_45946, Drosophila S2R+ RRID:CVCL_Z831, pHD-ScarlessDsRed vector RRID:DGRC_1364

Abstract

PIEZO and TRP channels are receptors for physical stimuli such as mechanical touch and temperature in sensory neurons. As these receptors are localized in the plasma membrane, the modulation of their activities by membrane lipids has recently attracted attention. In this study, we focused on ether phospholipids (ePLs) enriched in neurons and analyzed their role in somatosensation using Drosophila. Reduced mechanosensory behavior was observed with ePL-synthesizing gene knockout or knockdown in PIEZO-expressing neurons. PIEZO activation was significantly augmented in the presence of ePLs. Furthermore, we observed that ePLs modulate the thermosensory behavior and reduce the temperature threshold of TRPA1. Finally, we revealed that ePLs affect membrane tension and lipid order of the plasma membrane in cultured cells. Our study identified ePLs as a modulator of a specific set of receptors for multiple somatosensory modalities, which underscores the significance of functional interaction between membrane lipids and sensory channel proteins.

Reproduced under the paper's license (CC BY), from the paper cited above.

Code

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All data reported in this article will be shared by the lead contact upon request.

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Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

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Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 11 authors, 3 keywords, 5 funders, 91 references, 6 RRIDs.

Cite

This paper

Suito, T., Deng, X., Sato, S., Nagao, K., Ganser, C., Uchihashi, T., Tsutsumi, M., Nemoto, T., Hara, Y., Tominaga, M., & Sokabe, T. (2026). Ether phospholipids modulate somatosensory responses by tuning multiple receptor functions in <i>Drosophila</i>. iScience, 29(4), 115209. https://doi.org/10.1016/j.isci.2026.115209

BibTeX

@article{suito2026ether,
author = {Suito, Takuto and Deng, Xiangmei and Sato, Shoma and Nagao, Kohjiro and Ganser, Christian and Uchihashi, Takayuki and Tsutsumi, Motosuke and Nemoto, Tomomi and Hara, Yuji and Tominaga, Makoto and Sokabe, Takaaki},
title = {{Ether phospholipids modulate somatosensory responses by tuning multiple receptor functions in \<i\>Drosophila\</i\>}},
journal = {iScience},
year = {2026},
month = mar,
volume = {29},
number = {4},
pages = {115209},
publisher = {Elsevier},
issn = {2589-0042},
doi = {10.1016/j.isci.2026.115209},
url = {https://doi.org/10.1016/j.isci.2026.115209},
pmid = {41907445},
pmcid = {PMC13018890}
}

RIS

TY - JOUR
AU - Suito, Takuto
AU - Deng, Xiangmei
AU - Sato, Shoma
AU - Nagao, Kohjiro
AU - Ganser, Christian
AU - Uchihashi, Takayuki
AU - Tsutsumi, Motosuke
AU - Nemoto, Tomomi
AU - Hara, Yuji
AU - Tominaga, Makoto
AU - Sokabe, Takaaki
TI - Ether phospholipids modulate somatosensory responses by tuning multiple receptor functions in <i>Drosophila</i>
T2 - iScience
J2 - iScience
PY - 2026
DA - 2026/03/03
VL - 29
IS - 4
SP - 115209
SN - 2589-0042
PB - Elsevier
DO - 10.1016/j.isci.2026.115209
UR - https://doi.org/10.1016/j.isci.2026.115209
LA - en
ER -

CSL-JSON

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