Changes in the microglial phenotype drive neuroinflammation independent of systemic inflammation in the acute stage of heatstroke.
Overview
- Department of Tropical Medicine, Army Medical University, Chongqing, China
- Department of Neurology, Xinqiao Hospital, Army Medical University, Chongqing, China
Abstract
Heatstroke causes acute injury and damage across numerous organ systems, during this process, inflammation drives disease progression. In this study, we correlated temporal changes in inflammatory response with barrier breakdown within 24 h following heatstroke onset to explore whether inflammation in circulation can influence inflammation in brain. We found both pro-inflammatory cytokines expression and pathological lesions in tissue were elevated at 1 h and 6 h after heatstroke onset. However, by 24 h after heatstroke onset, while systemic inflammation was sustained at high levels, neuroinflammation and cerebral cortex damage had begun to reverse. The change in microglial phenotype from classic activation at 1 h to alternative activation at 24 h post heatstroke may explain the subsequent abatement of neuroinflammation. Taken together, our results may indicate microglial phenotype transformation drives neuroinflammation independent of systemic inflammation during the acute stage of heatstroke.
Reproduced under the paper's license (CC BY), from the paper cited above.
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• All data reported in this paper will be shared by the lead contact upon request. • This paper does not report original code. • Any additional information required to reanalyze the reported in this paper is available from the lead contact upon request.
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Version 1, 30 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 9 authors, 1 keyword, 1 funder, 42 references, 11 RRIDs.
Cite
This paper
Li, P., Wang, Z., Liu, J., Wang, G., Luo, X., Luo, Z., Shen, T., He, G., & Yang, X. (2026). Changes in the microglial phenotype drive neuroinflammation independent of systemic inflammation in the acute stage of heatstroke. iScience, 29(4), 115254. https://
BibTeX
@article{li2026changes,
author = {Li, Ping and Wang, Zeze and Liu, Jun and Wang, Gong and Luo, Xue and Luo, Zhen and Shen, Tingting and He, Genlin and Yang, Xuesen},
title = {{Changes in the microglial phenotype drive neuroinflammation independent of systemic inflammation in the acute stage of heatstroke}},
journal = {iScience},
year = {2026},
month = mar,
volume = {29},
number = {4},
pages = {115254},
publisher = {Elsevier},
issn = {2589-0042},
doi = {10.1016/
url = {https://
pmid = {41959670},
pmcid = {PMC13058986}
}
RIS
TY - JOUR
AU - Li, Ping
AU - Wang, Zeze
AU - Liu, Jun
AU - Wang, Gong
AU - Luo, Xue
AU - Luo, Zhen
AU - Shen, Tingting
AU - He, Genlin
AU - Yang, Xuesen
TI - Changes in the microglial phenotype drive neuroinflammation independent of systemic inflammation in the acute stage of heatstroke
T2 - iScience
J2 - iScience
PY - 2026
DA - 2026/
VL - 29
IS - 4
SP - 115254
SN - 2589-0042
PB - Elsevier
DO - 10.1016/
UR - https://
LA - en
ER -
CSL-JSON
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