OSCR

Transcranial photobiomodulation mitigates neuroinflammation by suppressing the activation of neurotoxic microglia through inhibition of the cGAS-STING pathway following intracerebral hemorrhage in mice.

Overview

Authors: Yitong Du1, Song Wang2, Yuhualei Pan1, Huixuan Ma1, Yushang Zhao1, Zheng Wei1, Huadong Lu3, Dan Xie1,4, Yongbo Zhang5
  1. Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
  2. Experimental and Translational Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
  3. State Key Laboratory of Quantum Optics and Quantum Optics Devices, Institute of Opto-Electronics, Shanxi University, Taiyuan, Shanxi 030006, China
  4. The People’s Hospital of Wu Hai Inner Mongolia, Wuhai, Inner Mongolia 016000, China
  5. Center for Neurological disorders, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
Institutions: Capital Medical University (China); Beijing Friendship Hospital (China); Shanxi University (China); State Key Laboratory of Quantum Optics and Quantum Optics Devices
Journal: Chinese medical journal, volume 139, issue 12, pages 1846-1858
Dates: received 16 September 2025; published online 27 April 2026; in print 20 June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1097/cm9.0000000000004019 · PMID 42045151 · PMCID PMC13282097 · OpenAlex W7156988008
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: mouse (organism), stroke (population), cellular / molecular (subfield)
Methods: Statistics
Keywords: Transcranial photobiomodulation, Intracerebral hemorrhage, Blood–brain barrier, Neutrophil, Microglia, cGAS-STING
MeSH: Cerebral Hemorrhage*, Low-Level Light Therapy*, Membrane Proteins*, Microglia*, Neuroinflammatory Diseases*, Nucleotidyltransferases*, Animals, Blood-Brain Barrier, Brain Edema, cGAS-STING Signaling Pathway, Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase, Male, Mice, Mice, Inbred C57BL, Signal Transduction, STING Protein (* major topic)
Topic: Intracerebral and Subarachnoid Hemorrhage Research (Neurology, Medicine), according to OpenAlex
Citations: not cited yet (Europe PMC); 40 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Versions

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Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 9 authors, 6 keywords, 16 MeSH terms, 40 references.

Cite

This paper

Du, Y., Wang, S., Pan, Y., Ma, H., Zhao, Y., Wei, Z., Lu, H., Xie, D., & Zhang, Y. (2026). Transcranial photobiomodulation mitigates neuroinflammation by suppressing the activation of neurotoxic microglia through inhibition of the cGAS-STING pathway following intracerebral hemorrhage in mice. Chinese medical journal, 139(12), 1846-1858. https://doi.org/10.1097/cm9.0000000000004019

BibTeX

@article{du2026transcranial,
author = {Du, Yitong and Wang, Song and Pan, Yuhualei and Ma, Huixuan and Zhao, Yushang and Wei, Zheng and Lu, Huadong and Xie, Dan and Zhang, Yongbo},
title = {{Transcranial photobiomodulation mitigates neuroinflammation by suppressing the activation of neurotoxic microglia through inhibition of the cGAS-STING pathway following intracerebral hemorrhage in mice}},
journal = {Chinese medical journal},
year = {2026},
month = apr,
volume = {139},
number = {12},
pages = {1846--1858},
publisher = {Wolters Kluwer Health},
issn = {0366-6999},
doi = {10.1097/cm9.0000000000004019},
url = {https://doi.org/10.1097/cm9.0000000000004019},
pmid = {42045151},
pmcid = {PMC13282097}
}

RIS

TY - JOUR
AU - Du, Yitong
AU - Wang, Song
AU - Pan, Yuhualei
AU - Ma, Huixuan
AU - Zhao, Yushang
AU - Wei, Zheng
AU - Lu, Huadong
AU - Xie, Dan
AU - Zhang, Yongbo
TI - Transcranial photobiomodulation mitigates neuroinflammation by suppressing the activation of neurotoxic microglia through inhibition of the cGAS-STING pathway following intracerebral hemorrhage in mice
T2 - Chinese medical journal
J2 - Chin Med J (Engl)
PY - 2026
DA - 2026/04/27
VL - 139
IS - 12
SP - 1846
EP - 1858
SN - 0366-6999
PB - Wolters Kluwer Health
DO - 10.1097/cm9.0000000000004019
UR - https://doi.org/10.1097/cm9.0000000000004019
LA - en
ER -

CSL-JSON

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"language": "en",
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